Protein Alignment TyrR and Hrh4

DIOPT Version :10

• Sequence 1: NP_650652.1
• Gene: TyrR / 42136
• FlyBaseID: FBgn0038542
• Length: 631
• Species: Drosophila melanogaster
• Sequence 2: NP_694727.1
• Gene: Hrh4 / 225192
• MGIID: 2429635
• Length: 391
• Species: Mus musculus
• Alignment Length: 502
• Identity: 113/502 - (22%)
• Similarity: 188/502 - (37%)
• Gaps: 153/502 - (30%)

  Fly   119 LIAVFATFIVVTVIGNTLVILAILTTRRLRTITNCFVMSLAVADLLVGIFVMPPAVAVHLIGSWQ 183
            |..:.::|....::||.:||||.:..|.||..:|.|.::||::|.|||:..:|..:. |::.:|.
Mouse    18 LAFLMSSFAFAIMVGNAVVILAFVVDRNLRHRSNYFFLNLAISDFLVGLISIPLYIP-HVLFNWN 81

  Fly   184 LGWVLCDIWISLDVLLCTASILSLCAISVDRYLAVTRPLTYSRKRRSKRLALIMILIVWLLALAI 248
            .|..:|..|:..|.||||||:.::..||.|||.:|:..::|..:.......:..::.||:||..:
Mouse    82 FGSGICMFWLITDYLLCTASVYNIVLISYDRYQSVSNAVSYRAQHTGIMKIVAQMVAVWILAFLV 146

  Fly   249 TCPPML---GWYEPGRRDLRECRYN-QNEGYVI-FSAMGSFFIPMAVMIYVYARISCVIASRHDN 308
            ..|.:|   .|  ....:.::|... ..|.|:: .:.:..|.:|:..:.|.
Mouse   147 NGPMILASDSW--KNSTNTKDCEPGFVTEWYILTITMLLEFLLPVISVAYF-------------- 195

  Fly   309 MTDISVHNKKFKRYTAADVENELSEQEQHSSVGQRQRQATSRTFSNQTIAKELQDMMLSDSDNCA 373
              ::.::...:|                        |:|.||..|:
Mouse   196 --NVQIYWSLWK------------------------RRALSRCPSH------------------- 215

  Fly   374 AMGAGGAGGGGGGASSATGGTHCQSLLALPSGGVGGSMGCAKNGCYELTRPSSLKRASTASTTIT 438
                   .|....:|||:|..|                                 ||..|..|
Mouse   216 -------AGFSTTSSSASGHLH---------------------------------RAGVACRT-- 238

  Fly   439 TMTSGMGPGSSLLDAQWQSQPPGQTGQVQTHSLSQPPRTHSFRHSHGERDRERLRSHHHHPHYHH 503
                              |.|..:......||.| |.|..|...|        ||:|
Mouse   239 ------------------SNPGLKESAASRHSES-PRRKSSILVS--------LRTH-------- 268

  Fly   504 QAGVTTTSTSGNTSANTNSKSLSNR---ITSLKKENKTTQTLSIVVGGFIACWLPF--FINYLIT 563
               :.::.|:....:...|:|.:.|   ...|.:..|..::|:|::..|..||.|:  |...|.|
Mouse   269 ---MNSSITAFKVGSFWRSESAALRQREYAELLRGRKLARSLAILLSAFAICWAPYCLFTIVLST 330

  Fly   564 PFLAEHQASQMLAKALTWLGWFNSAINPFIYAFYSVDFRAAFWRLTC 610
            ....|...|...:.|. ||.||||.:|||:|......|:.|||::.|
Mouse   331 YPRTERPKSVWYSIAF-WLQWFNSFVNPFLYPLCHRRFQKAFWKILC 376

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TyrR	NP_650652.1	7tmA_tyramine_R-like	118..>304	CDD:320189	52/189 (28%)
		TM helix 1	118..144	CDD:320189	8/24 (33%)
		TM helix 2	151..177	CDD:320189	9/25 (36%)
		TM helix 3	189..219	CDD:320189	14/29 (48%)
		TM helix 4	232..255	CDD:320189	6/25 (24%)
		TM helix 5	272..297	CDD:320189	5/25 (20%)
		7tm_GPCRs	<533..605	CDD:475119	24/73 (33%)
		TM helix 6	539..561	CDD:320189	7/23 (30%)
		TM helix 7	573..598	CDD:320189	11/24 (46%)
Hrh4	NP_694727.1	7tm_GPCRs	16..376	CDD:475119	112/500 (22%)
		TM helix 1	18..42	CDD:410628	8/23 (35%)
		TM helix 2	51..73	CDD:410628	9/21 (43%)
		TM helix 3	88..110	CDD:410628	9/21 (43%)
		TM helix 4	134..150	CDD:410628	4/15 (27%)
		TM helix 5	174..197	CDD:410628	4/38 (11%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	238..258		7/40 (18%)
		TM helix 6	304..326	CDD:410628	7/21 (33%)
		TM helix 7	339..364	CDD:410628	12/25 (48%)