Protein Alignment TyrR and Taar8a

DIOPT Version :10

• Sequence 1: NP_650652.1
• Gene: TyrR / 42136
• FlyBaseID: FBgn0038542
• Length: 631
• Species: Drosophila melanogaster
• Sequence 2: NP_001010830.1
• Gene: Taar8a / 215859
• MGIID: 2685076
• Length: 344
• Species: Mus musculus
• Alignment Length: 509
• Identity: 106/509 - (20%)
• Similarity: 156/509 - (30%)
• Gaps: 239/509 - (46%)

  Fly   117 IILIAVFATFIVVTVIGNTLVILAILTTRRLRTITNCFVMSLAVADLLVGIFVMPPAVAVHLIGS 181
            :||..|:....|:.|.||.||::::|..::|.:..|..:.|||.||.||||.|||.::...:...
Mouse    32 VILYMVYGFGAVLAVCGNLLVVISVLHFKQLHSPANFLIASLASADFLVGISVMPFSMVRSIESC 96

  Fly   182 WQLGWVLCDIWISLDVLLCTASILSLCAISVDRYLAVTRPLTYSRKRRSKRLALIMILIVWLLAL 246
            |..|...|.:....||..|.:|:|.||.||||||:|||.||.|..| .:..::.|.|.|.|:|.|
Mouse    97 WYFGDAFCSLHSCCDVAFCYSSVLHLCFISVDRYIAVTDPLVYPTK-FTVSVSGICISISWILPL 160

  Fly   247 ---------------------AITCPPMLGWYEPGRRDLRECRYNQNEGYVIFSAMGSFFIPMAV 290
                                 |:.|             :..|:...|:.:|:.|.: .||||..|
Mouse   161 VYSSAVFYTGISAKGIESLVSALNC-------------VGGCQIVINQDFVLISFL-LFFIPTLV 211

  Fly   291 MIYVYARISCVIASRHDNMTDISVHNKKFKRYTAADVENELSEQEQHSSVGQRQRQATSRTFSNQ 355
            ||.:|::|..|
Mouse   212 MIILYSKIFLV------------------------------------------------------ 222

  Fly   356 TIAKELQDMMLSDSDNCAAMGAGGAGGGGGGASSATGGTHCQSLLALPSGGVGGSMGCAKNGCYE 420
              ||:
Mouse   223 --AKQ------------------------------------------------------------ 225

  Fly   421 LTRPSSLKRASTASTTITTMTSGMGPGSSLLDAQWQSQPPGQTGQVQTHSLSQPPRTHSFRHSHG 485
                                                                             
Mouse   226 ----------------------------------------------------------------- 225

  Fly   486 ERDRERLRSHHHHPHYHHQAGVTTTSTSGNTSANTNSKSLSNRITSLKKENKTTQTLSIVVGGFI 550
                              ||....||.|||..   .|.|.|::....|:|.|..:||.:.|..|:
Mouse   226 ------------------QAVKIETSVSGNRG---ESSSESHKARVAKRERKAAKTLGVTVVAFM 269

  Fly   551 ACWLPFFINYLITPFLAEHQASQMLAKALTWLGWFNSAINPFIYAFYSVDFRAA 604
            ..|||:.|:.|:..|:. ......:.:...|..::|||:||.||||:...|:.|
Mouse   270 VSWLPYTIDALVDAFMG-FITPAYVYEICCWGTYYNSAMNPLIYAFFFPWFKKA 322

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TyrR	NP_650652.1	7tmA_tyramine_R-like	118..>304	CDD:320189	69/206 (33%)
		TM helix 1	118..144	CDD:320189	10/25 (40%)
		TM helix 2	151..177	CDD:320189	13/25 (52%)
		TM helix 3	189..219	CDD:320189	15/29 (52%)
		TM helix 4	232..255	CDD:320189	8/43 (19%)
		TM helix 5	272..297	CDD:320189	11/24 (46%)
		7tm_GPCRs	<533..605	CDD:475119	25/72 (35%)
		TM helix 6	539..561	CDD:320189	8/21 (38%)
		TM helix 7	573..598	CDD:320189	10/24 (42%)
Taar8a	NP_001010830.1	7tm_GPCRs	32..323	CDD:475119	106/509 (21%)
		TM helix 1	34..58	CDD:320439	8/23 (35%)
		TM helix 2	67..89	CDD:320439	13/21 (62%)
		TM helix 3	105..127	CDD:320439	8/21 (38%)
		TM helix 4	150..166	CDD:320439	6/15 (40%)
		TM helix 5	194..217	CDD:320439	10/23 (43%)
		TM helix 6	258..280	CDD:320439	8/21 (38%)
		TM helix 7	291..316	CDD:320439	10/24 (42%)