Protein Alignment TyrR and tyra-3

DIOPT Version :9

• Sequence 1: NP_001287381.1
• Gene: TyrR / 42136
• FlyBaseID: FBgn0038542
• Length: 631
• Species: Drosophila melanogaster
• Sequence 2: NP_001024805.1
• Gene: tyra-3 / 187427
• WormBaseID: WBGene00006475
• Length: 592
• Species: Caenorhabditis elegans
• Alignment Length: 555
• Identity: 164/555 - (29%)
• Similarity: 257/555 - (46%)
• Gaps: 111/555 - (20%)

  Fly   118 ILIAVF-ATFIVVTVIGNTLVILAILTTRRLRTITNCFVMSLAVADLLVGIFVMPPAVAVHLIGS 181
            :.||:| ...|::|:.||.||:|:::..:|:||.||..:.|||.||||||:.|||.:: :.|:.:
 Worm   100 VFIALFLVMLILLTIFGNILVVLSVVVYKRMRTFTNILLTSLATADLLVGLIVMPMSL-LDLLHN 163

  Fly   182 --WQLGWVLCDIWISLDVLLCTASILSLCAISVDRYLAVTRPLTYSRKRRSKRLALIMILIVWLL 244
              |.||..||.:|.:.||||||||||:||.||:|||.|:|.||.|.| .||:::|..::..||.:
 Worm   164 HRWPLGRFLCRMWATSDVLLCTASILNLCVISLDRYFAITSPLKYPR-TRSRKMAAGLLTAVWAI 227

  Fly   245 ALAITCPPMLGWYEP------------GRRDLRECRYNQNEGYVIFSAMGSFFIPMAVMIYVYAR 297
            :..:..||   |..|            |..:..:|.|:.:..|.|:||:|||::|:.||::||.:
 Worm   228 SFVVCSPP---WVIPSWNLFIDNNNNTGSSEDFKCAYSPSVAYRIYSALGSFYLPLLVMLFVYFK 289

  Fly   298 ISCVIASRH-------------DNMTDISVHNKKFKRYTAADVENELSEQEQHSSVGQRQRQATS 349
            |..|.:.|.             :.:|.....|::....||:...:....|..| :.|:.......
 Worm   290 IFRVASEREALMRQSVGTCRLSNRLTKTQQKNQRNNLRTASAPHSRTRVQVNH-NCGRVNYSVRP 353

  Fly   350 RTFSNQTIAKELQDMMLSDSDNCAAMGAGGAGGGGGGASSATGGTHCQSLLAL----PSGGVGGS 410
            ..::|:............||.:|......|        .|...||.|...::|    |..|:...
 Worm   354 VEYANRVENSLKPSHERFDSTDCEDSPPNG--------DSLEAGTTCNISMSLVTNSPPNGLQKE 410

  Fly   411 MGCAKNG----CYELTRPSSLKRASTASTTITTMTS-GMGPGSSLLDAQWQSQPPGQTGQVQTHS 470
               |||.    |:.|.     ...::|.|.:...|. |:.|..|....|..:       ::|.::
 Worm   411 ---AKNSMERECHSLA-----DIVNSADTPVRKNTEVGVAPSLSKRARQCNA-------RLQPNN 460

  Fly   471 LSQPPRTHSFRHSHGERDRERLRSHHHHPHYHHQAGVTTTSTSGNTSANTNSKSLSNRITSLKKE 535
            |.|                   ::|.|:            ..:|...|...||   .::..: :|
 Worm   461 LLQ-------------------KAHEHY------------QINGPGKAVRGSK---EKMVYM-RE 490

  Fly   536 NKTTQTLSIVVGGFIACWLPFFINYLITPFL----AEHQASQMLAKALTWLGWFNSAINPFIYAF 596
            .|..:|:.|||.|||.||:||||.||:..|:    ||....::.::...|||:.||.:||.||..
 Worm   491 RKALKTIGIVVLGFIICWMPFFIMYLVEVFISDPVAESPIYRITSEFFLWLGYSNSVLNPIIYTM 555

  Fly   597 YSVDFRAAFWRLTCKRFFSAGQKPQFPTNTMSIRR 631
            |:.|||..|     :...|.| ..|....|||:::
 Worm   556 YNGDFRRCF-----RDLLSFG-CVQHHRRTMSVKK 584

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TyrR	NP_001287381.1	7tm_4	127..>249	CDD:304433	59/123 (48%)
		7tm_1	133..>298	CDD:278431	76/178 (43%)
tyra-3	NP_001024805.1	7tmA_tyramine_R-like	101..>300	CDD:320189	84/203 (41%)
		TM helix 1	102..126	CDD:320189	10/23 (43%)
		TM helix 2	135..157	CDD:320189	13/21 (62%)
		TM helix 3	174..196	CDD:320189	14/21 (67%)
		TM helix 4	219..235	CDD:320189	2/15 (13%)
		TM helix 5	265..288	CDD:320189	11/22 (50%)
		7tm_GPCRs	<486..564	CDD:391938	33/78 (42%)
		TM helix 6	488..518	CDD:341315	17/30 (57%)
		TM helix 7	532..557	CDD:341315	9/24 (38%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S6630
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D189663at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X4088
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.870