Protein Alignment TyrR and ser-5

DIOPT Version :10

• Sequence 1: NP_650652.1
• Gene: TyrR / 42136
• FlyBaseID: FBgn0038542
• Length: 631
• Species: Drosophila melanogaster
• Sequence 2: NP_492273.2
• Gene: ser-5 / 184572
• WormBaseID: WBGene00008890
• Length: 454
• Species: Caenorhabditis elegans
• Alignment Length: 499
• Identity: 115/499 - (23%)
• Similarity: 177/499 - (35%)
• Gaps: 198/499 - (39%)

  Fly   117 IILIAVFATFIV-VTVIGNTLVILAILTTRRLRTITNCFVMSLAVADLLVGIFVMPPAVAVHLI- 179
            ::|:.:.|..|: :|:.||.||:  ....|..||.|...|.:|.:.|.|||:.|:|.. ||:||
 Worm    62 LVLLCIPAVIIILLTIFGNLLVL--FFKARVGRTNTTLLVWNLGLTDFLVGVIVLPMG-AVYLIY 123

  Fly   180 GSWQLGWVLCDIWISLDVLLCTASILSLCAISVDRYLAVTRPLTYSRKRRSKRLALIMILIVWLL 244
            ..|..|..||.:|::.||..||.|::::|.|||||||||||||.| :...:|...:.::.|:|:.
 Worm   124 RKWIFGRFLCRLWVAADVTFCTCSVVTICVISVDRYLAVTRPLRY-KSIVTKTKVISVMTIIWIF 187

  Fly   245 ALAITCPPMLGWYEPGRRDLRECRYNQNEGYVIFSAMGSFFIPMAVMIYVYARISCVIASRHDNM 309
            :.:|.. ..:.|.:|...|...|.......::..|.:.:||:|.:|.:.:|.||
 Worm   188 SSSILL-TTVRWEQPECYDDSLCFVGNEIRHLAHSVVFAFFLPASVTLTLYWRI----------- 240

  Fly   310 TDISVHNKKFKRYTAADVENELSEQEQHSSVGQRQRQ-ATSRTFSNQTIAKELQDMMLSDSDNCA 373
                        |..|                 |.|| |..|.|           :|:
 Worm   241 ------------YKLA-----------------RNRQKALDRGF-----------LMI------- 258

  Fly   374 AMGAGGAGGGGGGASSATGGTHCQSLLALPSGGVGGSMGCAKNGCYELTRPSSLKRASTASTTIT 438
                                                                             
 Worm   259 ----------------------------------------------------------------- 258

  Fly   439 TMTSGMGPGSSLLDAQWQSQPPGQTGQVQTHSLSQPP--RTHSFRHSHG--ERDRERLRSHHHHP 499
                 :|...:.|                |::|||..  |.| |..::|  |..|..||:|
 Worm   259 -----LGSNMNFL----------------TNTLSQQTTLRVH-FGKTNGMVEHQRRVLRTH---- 297

  Fly   500 HYHHQAGVTTTSTSGNTSANTNSKSLSNRITSLKKENKTTQTLSIVVGGFIACWLPFFINYLITP 564
                                                .:..:||.:|...|:.||||||..|| |.
 Worm   298 ------------------------------------ERIAKTLGVVSCSFLFCWLPFFGLYL-TN 325

  Fly   565 FLAEHQASQMLAKALTWLGWFNSAINPFIYAFYSVDFRAAFWRL 608
            :........:.....:|||:.||.:||.||:|...:|:.:.:||
 Worm   326 YKCSGCVPPIAIDVASWLGYCNSMLNPIIYSFTVKEFKRSAFRL 369

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TyrR	NP_650652.1	7tmA_tyramine_R-like	118..>304	CDD:320189	65/187 (35%)
		TM helix 1	118..144	CDD:320189	8/26 (31%)
		TM helix 2	151..177	CDD:320189	10/25 (40%)
		TM helix 3	189..219	CDD:320189	16/29 (55%)
		TM helix 4	232..255	CDD:320189	3/22 (14%)
		TM helix 5	272..297	CDD:320189	6/24 (25%)
		7tm_GPCRs	<533..605	CDD:475119	24/71 (34%)
		TM helix 6	539..561	CDD:320189	10/21 (48%)
		TM helix 7	573..598	CDD:320189	10/24 (42%)
ser-5	NP_492273.2	7tmA_amine_R-like	64..365	CDD:320098	113/491 (23%)
		TM helix 1	64..88	CDD:320098	8/25 (32%)
		TM helix 2	95..122	CDD:320098	11/27 (41%)
		TM helix 3	133..163	CDD:320098	16/29 (55%)
		TM helix 4	175..195	CDD:320098	3/20 (15%)
		TM helix 5	214..294	CDD:320098	29/224 (13%)
		TM helix 6	295..325	CDD:320098	14/70 (20%)
		TM helix 7	334..359	CDD:320098	10/24 (42%)