Protein Alignment TyrR and ser-2

DIOPT Version :10

• Sequence 1: NP_650652.1
• Gene: TyrR / 42136
• FlyBaseID: FBgn0038542
• Length: 631
• Species: Drosophila melanogaster
• Sequence 2: NP_001024339.1
• Gene: ser-2 / 182110
• WormBaseID: WBGene00004777
• Length: 455
• Species: Caenorhabditis elegans
• Alignment Length: 512
• Identity: 144/512 - (28%)
• Similarity: 229/512 - (44%)
• Gaps: 134/512 - (26%)

  Fly   109 DLVLSWQGIILIAVFATFIVVTVIGNTLVILAILTTRRLRTITNCFVMSLAVADLLVGIFVMPPA 173
            :|||   |.|   .:...|.:||:|||||::|:.:.|.|:.:.|.|::|||.:||.|.|||||..
 Worm    56 ELVL---GTI---TYLVIIAMTVVGNTLVVVAVFSYRPLKKVQNYFLVSLAASDLAVAIFVMPLH 114

  Fly   174 VAVHLI-GSWQLGWVLCDIWISLDVLLCTASILSLCAISVDRYLAVTRPLTYSRKRRSKRLALIM 237
            |...|. |.|.||..:|..:.:.|:||||:|||:||||::|||.|:..|:.|::||.:| ...|:
 Worm   115 VVTFLAGGKWLLGVTVCQFFTTADILLCTSSILNLCAIALDRYWAIHNPINYAQKRTTK-FVCIV 178

  Fly   238 ILIVWLLALAITCPPMLGWYEPGRRDLRE--CRYNQNEGYVIFSAMGSFFIPMAVMIYVYARISC 300
            |:|||:|::.|:.||::|| ...:.::.|  |..:..:.:|:|||.||||:|:.||:.||.:|
 Worm   179 IVIVWILSMLISVPPIIGW-NNWQENMMEDSCGLSTEKAFVVFSAAGSFFLPLLVMVVVYVKI-- 240

  Fly   301 VIASRHDNMTDISVHNKKFKRYTAADVENELSEQEQHSSVGQRQRQATSRTFSNQTIAKELQDMM 365
                                                  .:..|||..|:|   .::....:|:
 Worm   241 --------------------------------------FISARQRIRTNR---GRSALMRIQN-- 262

  Fly   366 LSDSDNCAAMGAGGAGGGGGGASSATGGTHCQSLLALPSGGVGGSMGCAKNGCYELTRPSSLKRA 430
            ....|:...|....|.......||..|.   ::.|.:..|
 Worm   263 AEGDDDYRKMSIKRASVESARTSSRVGE---KTPLVIADG------------------------- 299

  Fly   431 STASTTITTMTSGMGPGSSLLDAQWQSQPPGQTGQVQTHSLSQPPRTHSFRHSHGERDRERLRSH 495
               .||:||:.:....|.||        |..:|.:
 Worm   300 ---QTTVTTLAAHSTDGGSL--------PKDETTK------------------------------ 323

  Fly   496 HHHPHYHHQAGV-----TTTSTSGNTSANTNSKSLSNRITSLKKENKTTQTLSIVVGGFIACWLP 555
              |..||:....     ......||  .|..:........|:.||.:..:|:::::..|..||||
 Worm   324 --HMKYHNNGSCKVKVKDVKEDEGN--PNPTAVLRKREKISVAKEKRAAKTIAVIIFVFSFCWLP 384

  Fly   556 FFINYLITPFLAEHQASQMLAKALTWLGWFNSAINPFIYAFYSVDFRAAFWRLTCKR 612
            ||:.|:|.||....:....:.:|.||||:.||::|||:|...:::||.||.::.|.:
 Worm   385 FFVAYVIRPFCETCKLHAKVEQAFTWLGYINSSLNPFLYGILNLEFRRAFKKILCPK 441

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TyrR	NP_650652.1	7tmA_tyramine_R-like	118..>304	CDD:320189	80/188 (43%)
		TM helix 1	118..144	CDD:320189	10/25 (40%)
		TM helix 2	151..177	CDD:320189	14/25 (56%)
		TM helix 3	189..219	CDD:320189	17/29 (59%)
		TM helix 4	232..255	CDD:320189	9/22 (41%)
		TM helix 5	272..297	CDD:320189	13/24 (54%)
		7tm_GPCRs	<533..605	CDD:475119	27/71 (38%)
		TM helix 6	539..561	CDD:320189	8/21 (38%)
		TM helix 7	573..598	CDD:320189	11/24 (46%)
ser-2	NP_001024339.1	7tmA_tyramine_octopamine_R-like	58..434	CDD:320188	140/501 (28%)
		TM helix 1	59..85	CDD:320188	12/31 (39%)
		TM helix 2	92..118	CDD:320188	14/25 (56%)
		TM helix 3	131..161	CDD:320188	17/29 (59%)
		TM helix 4	173..196	CDD:320188	10/23 (43%)
		TM helix 5	214..243	CDD:320188	14/68 (21%)
		TM helix 6	362..392	CDD:320188	11/29 (38%)
		TM helix 7	402..427	CDD:320188	11/24 (46%)