Protein Alignment TyrR and DRD5

DIOPT Version :10

• Sequence 1: NP_650652.1
• Gene: TyrR / 42136
• FlyBaseID: FBgn0038542
• Length: 631
• Species: Drosophila melanogaster
• Sequence 2: NP_000789.1
• Gene: DRD5 / 1816
• HGNCID: 3026
• Length: 477
• Species: Homo sapiens
• Alignment Length: 627
• Identity: 144/627 - (22%)
• Similarity: 210/627 - (33%)
• Gaps: 295/627 - (47%)

  Fly    54 NGTG-------------GGGVGGVGGGYPSGPNGTDAVALTEPGPTAPVTTFNYYNESAAAAEWA 105
            |||.             |..|||..|..|.||:
Human     7 NGTAYPGQFALYQQLAQGNAVGGSAGAPPLGPS-------------------------------- 39

  Fly   106 HFYDLVLSWQGIILIAVFATFIVVTVIGNTLVILAILTTRRLR-TITNCFVMSLAVADLLVGIFV 169
                      .::...:....|:.|::||.||..||:.:|.|| .:||.|::||||:||.|.:.|
Human    40 ----------QVVTACLLTLLIIWTLLGNVLVCAAIVRSRHLRANMTNVFIVSLAVSDLFVALLV 94

  Fly   170 MPPAVAVHLIGSWQLGWVLCDIWISLDVLLCTASILSLCAISVDRYLAVTRPLTYSRKRRSKRLA 234
            ||......:.|.|..| ..||:|::.|::..|||||:||.||||||.|::||..|.|| .::|:|
Human    95 MPWKAVAEVAGYWPFG-AFCDVWVAFDIMCSTASILNLCVISVDRYWAISRPFRYKRK-MTQRMA 157

  Fly   235 LIMILIVWLLALAIT-CPPMLGWYE-------------------PGRRDLRE-------CRYNQN 272
            |:|:.:.|.|::.|: .|..|.|:.                   |...|..|       |..:.|
Human   158 LVMVGLAWTLSILISFIPVQLNWHRDQAASWGGLDLPNNLANWTPWEEDFWEPDVNAENCDSSLN 222

  Fly   273 EGYVIFSAMGSFFIPMAVMIYVYARISCVIASRHDNMTDISVHNKKFKRYTAADVENELSEQEQH 337
            ..|.|.|::.||:||:|:||..|.||                       |..|.|
Human   223 RTYAISSSLISFYIPVAIMIVTYTRI-----------------------YRIAQV---------- 254

  Fly   338 SSVGQRQRQATSRTFSNQTIAKELQDMMLSDSDNCAAMGAGGAGGGGGGASSATGGTHCQSLLAL 402
                                                                             
Human   255 ----------------------------------------------------------------- 254

  Fly   403 PSGGVGGSMGCAKNGCYELTRPSSLKRASTASTTITTMTSGMGPGSSLLDAQWQSQPPGQTGQVQ 467
                             ::.|.|||:||:.
Human   255 -----------------QIRRISSLERAAE----------------------------------- 267

  Fly   468 THSLSQPPRTHSFRHSHGERDRERLRSHHHHPHYHHQAGVTTTSTSGNTSANTNSKSLSNRITSL 532
                                              |.|:..::.:.:.:||..          .|:
Human   268 ----------------------------------HAQSCRSSAACAPDTSLR----------ASI 288

  Fly   533 KKENKTTQTLSIVVGGFIACWLPFFINYLITPFLAEHQ---------ASQMLAKALTWLGWFNSA 588
            |||.|..:|||:::|.|:.|||||||...:.||.:.|.         .|:.......|.||.||:
Human   289 KKETKVLKTLSVIMGVFVCCWLPFFILNCMVPFCSGHPEGPPAGFPCVSETTFDVFVWFGWANSS 353

  Fly   589 INPFIYAFYSVDFRAAFWRLT-CKRFFSAGQKPQFPTNTMSI 629
            :||.|||| :.||:..|.:|. |..|.|     :.|..|::|
Human   354 LNPVIYAF-NADFQKVFAQLLGCSHFCS-----RTPVETVNI 389

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TyrR	NP_650652.1	7tmA_tyramine_R-like	118..>304	CDD:320189	78/213 (37%)
		TM helix 1	118..144	CDD:320189	8/25 (32%)
		TM helix 2	151..177	CDD:320189	13/25 (52%)
		TM helix 3	189..219	CDD:320189	18/29 (62%)
		TM helix 4	232..255	CDD:320189	8/23 (35%)
		TM helix 5	272..297	CDD:320189	12/24 (50%)
		7tm_GPCRs	<533..605	CDD:475119	33/80 (41%)
		TM helix 6	539..561	CDD:320189	12/21 (57%)
		TM helix 7	573..598	CDD:320189	11/24 (46%)
DRD5	NP_000789.1	7tm_GPCRs	41..369	CDD:475119	125/524 (24%)
		TM helix 1	43..67	CDD:410628	8/23 (35%)
		TM helix 2	77..99	CDD:410628	12/21 (57%)
		TM helix 3	114..136	CDD:410628	11/21 (52%)
		TM helix 4	159..175	CDD:410628	4/15 (27%)
		TM helix 5	223..246	CDD:410628	10/22 (45%)
		TM helix 6	295..317	CDD:410628	12/21 (57%)
		TM helix 7	338..363	CDD:410628	11/25 (44%)