Protein Alignment TyrR and DRD4

DIOPT Version :10

• Sequence 1: NP_650652.1
• Gene: TyrR / 42136
• FlyBaseID: FBgn0038542
• Length: 631
• Species: Drosophila melanogaster
• Sequence 2: NP_000788.2
• Gene: DRD4 / 1815
• HGNCID: 3025
• Length: 419
• Species: Homo sapiens
• Alignment Length: 574
• Identity: 151/574 - (26%)
• Similarity: 217/574 - (37%)
• Gaps: 202/574 - (35%)

  Fly    57 GGGGVGGVGGGYPSGPNGTDAVALTEPGPTAPVTTFNYYNESAAAAEWAHFYDLVLSWQGIILI- 120
            |.|...|...|..:|..|..|.||.                                 .|::||
Human    15 GRGPAAGASAGASAGLAGQGAAALV---------------------------------GGVLLIG 46

  Fly   121 AVFATFIVVTVIGNTLVILAILTTRRLRTITNCFVMSLAVADLLVGIFVMPPAVAVHLI-GSWQL 184
            ||.|        ||:||.:::.|.|.|:|.||.|::|||.||||:.:.|:|..|...:. |:|.|
Human    47 AVLA--------GNSLVCVSVATERALQTPTNSFIVSLAAADLLLALLVLPLFVYSEVQGGAWLL 103

  Fly   185 GWVLCDIWISLDVLLCTASILSLCAISVDRYLAVTRPLTYSRKRRSKRLALIMILIVWLLALAIT 249
            ...|||..:::||:||||||.:||||||||::||..||.|:|:..|:| .|::|...|||:.|:.
Human   104 SPRLCDALMAMDVMLCTASIFNLCAISVDRFVAVAVPLRYNRQGGSRR-QLLLIGATWLLSAAVA 167

  Fly   250 CPPMLGWYEPGRRDLRECRYNQNEGYVIFSAMGSFFIPMAVMIYVYARISCVIASRHDNMTDISV 314
            .|.:.|..:...||...||. ::..||::|::.|||:|..:|:.:|
Human   168 APVLCGLNDVRGRDPAVCRL-EDRDYVVYSSVCSFFLPCPLMLLLY------------------- 212

  Fly   315 HNKKFKRYTAADVENELSEQEQHSSVGQRQRQATSRTFSNQTIAKELQDMMLSDSDNCAAMGAGG 379
                                           .||.|......:|:..:           ..|...
Human   213 -------------------------------WATFRGLQRWEVARRAK-----------LHGRAP 235

  Fly   380 AGGGGGGASSATG----------GTHC-QSLLALPSGGVGGSMGCA-------KNGCYELTRPSS 426
            ....|.|..|.|.          |..| .....||.|..|..  ||       ::.|.....|.:
Human   236 RRPSGPGPPSPTPPAPRLPQDPCGPDCAPPAPGLPRGPCGPD--CAPAAPSLPQDPCGPDCAPPA 298

  Fly   427 LKRASTASTTITTMTSGMGP---GSSLL--DAQWQSQPPGQTGQVQTHSLSQPPRTHSFRHSHGE 486
                           .|:.|   ||:..  ||...:..|.||          ||:|
Human   299 ---------------PGLPPDPCGSNCAPPDAVRAAALPPQT----------PPQT--------- 329

  Fly   487 RDRERLRSHHHHPHYHHQAGVTTTSTSGNTSANTNSKSLSNRITSLKKENKTTQTLSIVVGGFIA 551
              |.|.|:                                 :||.  :|.|..:.|.:|||.|:.
Human   330 --RRRRRA---------------------------------KITG--RERKAMRVLPVVVGAFLL 357

  Fly   552 CWLPFFINYLITPFLAEHQASQMLAKALTWLGWFNSAINPFIYAFYSVDFRAAF 605
            ||.|||:.::.............|..|:||||:.|||:||.||..::.:||..|
Human   358 CWTPFFVVHITQALCPACSVPPRLVSAVTWLGYVNSALNPVIYTVFNAEFRNVF 411

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TyrR	NP_650652.1	7tmA_tyramine_R-like	118..>304	CDD:320189	77/187 (41%)
		TM helix 1	118..144	CDD:320189	9/26 (35%)
		TM helix 2	151..177	CDD:320189	13/25 (52%)
		TM helix 3	189..219	CDD:320189	19/29 (66%)
		TM helix 4	232..255	CDD:320189	8/22 (36%)
		TM helix 5	272..297	CDD:320189	9/24 (38%)
		7tm_GPCRs	<533..605	CDD:475119	27/71 (38%)
		TM helix 6	539..561	CDD:320189	10/21 (48%)
		TM helix 7	573..598	CDD:320189	13/24 (54%)
DRD4	NP_000788.2	7tmA_D4_dopamine_R	38..411	CDD:320434	142/549 (26%)
		TM helix 1	38..62	CDD:320434	11/64 (17%)
		TM helix 2	69..95	CDD:320434	13/25 (52%)
		TM helix 3	108..138	CDD:320434	19/29 (66%)
		TM helix 4	150..173	CDD:320434	8/23 (35%)
		TM helix 5	189..218	CDD:320434	11/78 (14%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	230..264		7/33 (21%)
		4 X 16 AA approximate tandem repeats of [PA]-A-P-G-L-P-[PQR]-[DG]-P-C-G-P-D-C-A-P	249..312		14/79 (18%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	317..336		9/72 (13%)
		TM helix 6	339..369	CDD:320434	12/31 (39%)
		TM helix 7	379..404	CDD:320434	13/24 (54%)