Protein Alignment TyrR and DRD2

DIOPT Version :9

• Sequence 1: NP_001287381.1
• Gene: TyrR / 42136
• FlyBaseID: FBgn0038542
• Length: 631
• Species: Drosophila melanogaster
• Sequence 2: NP_000786.1
• Gene: DRD2 / 1813
• HGNCID: 3023
• Length: 443
• Species: Homo sapiens
• Alignment Length: 518
• Identity: 159/518 - (30%)
• Similarity: 239/518 - (46%)
• Gaps: 103/518 - (19%)

  Fly    95 YNESAAAAEWAH--FYDLVLSWQGIILIAVFATFIVVTVIGNTLVILAILTTRRLRTITNCFVMS 157
            :|.|...|:..|  :|..:|:    :||||.       |.||.||.:|:...:.|:|.||..::|
Human    22 FNGSDGKADRPHYNYYATLLT----LLIAVI-------VFGNVLVCMAVSREKALQTTTNYLIVS 75

  Fly   158 LAVADLLVGIFVMPPAVAVHLIGSWQLGWVLCDIWISLDVLLCTASILSLCAISVDRYLAVTRPL 222
            ||||||||...|||..|.:.::|.|:...:.|||:::|||::||||||:|||||:|||.||..|:
Human    76 LAVADLLVATLVMPWVVYLEVVGEWKFSRIHCDIFVTLDVMMCTASILNLCAISIDRYTAVAMPM 140

  Fly   223 TYSRKRRSKRLALIMILIVWLLALAITCPPMLGWYEPGRRDLRECRYNQNEGYVIFSAMGSFFIP 287
            .|:.:..|||...:||.|||:|:..|:||.:.|.   ...|..|| ...|..:|::|::.||::|
Human   141 LYNTRYSSKRRVTVMISIVWVLSFTISCPLLFGL---NNADQNEC-IIANPAFVVYSSIVSFYVP 201

  Fly   288 MAVMIYVYARISCVIASRHDNMTDISVHNKKFKRYTAADVENELSEQEQHSSVGQRQRQATSRTF 352
            ..|.:.||.:|..|:..|...     |:.|:..|...|.:...|.....|.
Human   202 FIVTLLVYIKIYIVLRRRRKR-----VNTKRSSRAFRAHLRAPLKGNCTHP-------------- 247

  Fly   353 SNQTIAKELQDMMLSDSDNCAAMGAGGAGGGGGGASSATGGTHCQSLLALPSGGVGGSMGCAKNG 417
                     :||.|                             |..::             ..||
Human   248 ---------EDMKL-----------------------------CTVIM-------------KSNG 261

  Fly   418 CYELTRPSSLKRASTASTTITTMTSGMGPGSSLLDAQWQSQPPGQTGQVQTHSLSQPPRTHSFRH 482
            .:.:.| ..::.|..|......|.|...|...   .::...||..      |.|:.|..:|...|
Human   262 SFPVNR-RRVEAARRAQELEMEMLSSTSPPER---TRYSPIPPSH------HQLTLPDPSHHGLH 316

  Fly   483 SHGERDRERLRSHH--HHPHYHHQAGVTTTSTSGNTSANTNSKSLSNRITSLKKENKTTQTLSIV 545
            |..:...:..::.|  .||..   |.:....|..|....|:.|::|.|..|.:||.|.||.|:||
Human   317 STPDSPAKPEKNGHAKDHPKI---AKIFEIQTMPNGKTRTSLKTMSRRKLSQQKEKKATQMLAIV 378

  Fly   546 VGGFIACWLPFFINYLITPFLAEHQASQMLAKALTWLGWFNSAINPFIYAFYSVDFRAAFWRL 608
            :|.||.|||||||.:::. ...:.....:|..|.||||:.|||:||.||..::::||.||.::
Human   379 LGVFIICWLPFFITHILN-IHCDCNIPPVLYSAFTWLGYVNSAVNPIIYTTFNIEFRKAFLKI 440

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TyrR	NP_001287381.1	7tm_4	127..>249	CDD:304433	58/121 (48%)
		7tm_1	133..>298	CDD:278431	73/164 (45%)
DRD2	NP_000786.1	7tmA_D2_dopamine_R	35..437	CDD:320435	153/500 (31%)
		TM helix 1	37..61	CDD:320435	12/34 (35%)
		TM helix 2	70..92	CDD:320435	13/21 (62%)
		TM helix 3	108..130	CDD:320435	15/21 (71%)
		TM helix 4	154..170	CDD:320435	8/15 (53%)
		TM helix 5	187..210	CDD:320435	7/22 (32%)
		Interaction with PPP1R9B. /evidence=ECO:0000250	211..373		43/244 (18%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	281..332		12/59 (20%)
		TM helix 6	372..394	CDD:320435	15/21 (71%)
		TM helix 7	405..430	CDD:320435	13/24 (54%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D189663at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.920