DRSC/TRiP Functional Genomics Resources

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Protein Alignment TyrR and DRD1

DIOPT Version :10

Sequence 1:NP_650652.1 Gene:TyrR / 42136 FlyBaseID:FBgn0038542 Length:631 Species:Drosophila melanogaster
Sequence 2:NP_000785.1 Gene:DRD1 / 1812 HGNCID:3020 Length:446 Species:Homo sapiens


Alignment Length:537 Identity:138/537 - (25%)
Similarity:197/537 - (36%) Gaps:222/537 - (41%)


- Green bases have known domain annotations that are detailed below.


  Fly   118 ILIAVFATFIVV-TVIGNTLVILAILTTRRLRT-ITNCFVMSLAVADLLVGIFVMPPAVAVHLIG 180
            ||.|.|.:.::: |::|||||..|::..|.||: :||.||:||||:||||.:.|||......:.|
Human    24 ILTACFLSLLILSTLLGNTLVCAAVIRFRHLRSKVTNFFVISLAVSDLLVAVLVMPWKAVAEIAG 88

  Fly   181 SWQLGWVLCDIWISLDVLLCTASILSLCAISVDRYLAVTRPLTYSRKRRSKRLALIMILIVWLLA 245
            .|..| ..|:||::.|::..|||||:||.||||||.|::.|..|.||...| .|.|:|.:.|.|:
Human    89 FWPFG-SFCNIWVAFDIMCSTASILNLCVISVDRYWAISSPFRYERKMTPK-AAFILISVAWTLS 151

  Fly   246 LAIT-CPPMLGWYE-----PG-------RRDLRECRYNQNEGYVIFSAMGSFFIPMAVMIYVYAR 297
            :.|: .|..|.|::     |.       ...:..|..:.:..|.|.|::.||:||:|:||..|.|
Human   152 VLISFIPVQLSWHKAKPTSPSDGNATSLAETIDNCDSSLSRTYAISSSVISFYIPVAIMIVTYTR 216

  Fly   298 ISCVIASRHDNMTDISVHNKKFKRYTAADVENELSEQEQHSSVGQRQRQATSRTFSNQTIAKELQ 362
            |             ..:..|:.:|..|.:                                    
Human   217 I-------------YRIAQKQIRRIAALE------------------------------------ 232

  Fly   363 DMMLSDSDNCAAMGAGGAGGGGGGASSATGGTHCQSLLALPSGGVGGSMGCAKNGCYELTRPSSL 427
                                     .:|....:||:     :.|.|..:.|              
Human   233 -------------------------RAAVHAKNCQT-----TTGNGKPVEC-------------- 253

  Fly   428 KRASTASTTITTMTSGMGPGSSLLDAQWQSQPPGQTGQVQTHSLSQPPRTHSFRHSHGERDRERL 492
                                         |||..                 ||:           
Human   254 -----------------------------SQPES-----------------SFK----------- 261

  Fly   493 RSHHHHPHYHHQAGVTTTSTSGNTSANTNSKSLSNRITSLKKENKTTQTLSIVVGGFIACWLPFF 557
                                                 .|.|:|.|..:|||:::|.|:.||||||
Human   262 -------------------------------------MSFKRETKVLKTLSVIMGVFVCCWLPFF 289

  Fly   558 INYLITPFLAEHQASQMLAKALT-----WLGWFNSAINPFIYAFYSVDFRAAFWRLT-CKRFFSA 616
            |...|.||....:.......:.|     |.||.||::||.|||| :.|||.||..|. |.|...|
Human   290 ILNCILPFCGSGETQPFCIDSNTFDVFVWFGWANSSLNPIIYAF-NADFRKAFSTLLGCYRLCPA 353

  Fly   617 GQKPQFPTN----TMSI 629
                   ||    |:||
Human   354 -------TNNAIETVSI 363

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
TyrRNP_650652.1 7tmA_tyramine_R-like 118..>304 CDD:320189 79/200 (40%)
TM helix 1 118..144 CDD:320189 11/26 (42%)
TM helix 2 151..177 CDD:320189 15/25 (60%)
TM helix 3 189..219 CDD:320189 18/29 (62%)
TM helix 4 232..255 CDD:320189 7/23 (30%)
TM helix 5 272..297 CDD:320189 11/24 (46%)
7tm_GPCRs <533..605 CDD:475119 33/76 (43%)
TM helix 6 539..561 CDD:320189 12/21 (57%)
TM helix 7 573..598 CDD:320189 12/29 (41%)
DRD1NP_000785.1 7tmA_D1A_dopamine_R 23..341 CDD:320443 127/506 (25%)
TM helix 1 25..51 CDD:320443 10/25 (40%)
TM helix 2 59..86 CDD:320443 15/26 (58%)
TM helix 3 96..126 CDD:320443 18/29 (62%)
TM helix 4 138..161 CDD:320443 8/23 (35%)
TM helix 5 191..221 CDD:320443 13/42 (31%)
TM helix 6 265..295 CDD:320443 15/29 (52%)
TM helix 7 310..335 CDD:320443 12/25 (48%)

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