Protein Alignment TyrR and tyra-2

DIOPT Version :10

• Sequence 1: NP_650652.1
• Gene: TyrR / 42136
• FlyBaseID: FBgn0038542
• Length: 631
• Species: Drosophila melanogaster
• Sequence 2: NP_001033537.1
• Gene: tyra-2 / 180970
• WormBaseID: WBGene00017157
• Length: 468
• Species: Caenorhabditis elegans
• Alignment Length: 516
• Identity: 138/516 - (26%)
• Similarity: 226/516 - (43%)
• Gaps: 96/516 - (18%)

  Fly   124 ATFIVV--TVIGNTLVILAILTTRRLRTITNCFVMSLAVADLLVGIFVMPPAVAVHLIGSWQLGW 186
            |.|::|  |:..|:||.:.:....||:|:.|..|.:||.:||.:|:.|:|.:....:.|.|....
 Worm    24 ALFLLVLWTIFANSLVFIVLYKNPRLQTVPNLLVGNLAFSDLALGLIVLPLSSVYAIAGEWVFPD 88

  Fly   187 VLCDIWISLDVLLCTASILSLCAISVDRYLAVTRPLTYSRKRRSKRLALIMILIVWLLALAITCP 251
            .||::::|.|:|..||||.:|..:.:|||.|:|.|:.|..| |:||.|.||||.||:.:..|:..
 Worm    89 ALCEVFVSADILCSTASIWNLSIVGLDRYWAITSPVAYMSK-RNKRTAGIMILSVWISSALISLA 152

  Fly   252 PMLGW----------YEPGRRDLRECRYNQNEGYVIFSAMGSFFIPMAVMIYVYARISCVIA--- 303
            |:|||          ||. ...:|:|.:.....|.::||.||||||..:|.:||.:|....|
 Worm   153 PLLGWKQTAQTPNLIYEK-NNTVRQCTFLDLPSYTVYSATGSFFIPTLLMFFVYFKIYQAFAKHR 216

  Fly   304 SRHDNMTDISVHNKKFKRYTAADVENELSEQEQHSSVGQRQRQATSRTFSNQTIAKELQDMMLSD 368
            :|......::|.:...:::..:.:.:|:|..           ..||..|:.:...:|       |
 Worm   217 ARQIYRQKLAVSSHVIRKHIESTILHEISHV-----------LPTSDEFAKEEEEEE-------D 263

  Fly   369 SDNCAAMGAGGAGGGGGGASSATGGTHCQSLLALPSGGVGGSMGCAKNGCYELTRPSSLKRAS-T 432
            |::...:    ..|.|.|..:......|:.                        ..|..||.. |
 Worm   264 SESSGQV----ENGLGNGNDAIIEEDECED------------------------EDSDEKRDDHT 300

  Fly   433 ASTTITTMTSGMGPGSSL-LDAQWQSQPPGQTGQVQTHSLSQPPRTHSFRHSHGERDRERLRSHH 496
            :.||:|...:|......: .:|:.....|     ::..|..|.......| |......|:::.|.
 Worm   301 SMTTVTATVTGPTEAPYMKREAKISKSVP-----IEKESAIQKREAKPMR-SVMAISYEKVKRHK 359

  Fly   497 HHPHYHHQAGVTTTSTSGNTSANTNSKSLSN--RITSLKKENKTTQTLSIVVGGFIACWLPFFIN 559
                              |.......|||..  :..|..||.:..:.|.|::|.|..||.|||..
 Worm   360 ------------------NRKERIYRKSLQRKPKAISAAKERRGVKVLGIILGCFTVCWAPFFTM 406

  Fly   560 YLITPFLAEHQASQMLAKALTWLGWFNSAINPFIYAFYSVDFRAAFWRLTCKRFFSAGQKP 620
            |::..|..:...:..:...:||||:.|||:||.||..::.|::.|.     ||.|::.:||
 Worm   407 YVLVQFCKDCSPNAHIEMFITWLGYSNSAMNPIIYTVFNRDYQIAL-----KRLFTSEKKP 462

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TyrR	NP_650652.1	7tmA_tyramine_R-like	118..>304	CDD:320189	72/194 (37%)
		TM helix 1	118..144	CDD:320189	7/21 (33%)
		TM helix 2	151..177	CDD:320189	9/25 (36%)
		TM helix 3	189..219	CDD:320189	13/29 (45%)
		TM helix 4	232..255	CDD:320189	10/22 (45%)
		TM helix 5	272..297	CDD:320189	12/24 (50%)
		7tm_GPCRs	<533..605	CDD:475119	25/71 (35%)
		TM helix 6	539..561	CDD:320189	9/21 (43%)
		TM helix 7	573..598	CDD:320189	11/24 (46%)
tyra-2	NP_001033537.1	7tmA_amine_R-like	20..452	CDD:320098	132/499 (26%)
		TM helix 1	20..46	CDD:320098	7/21 (33%)
		TM helix 2	53..80	CDD:320098	9/26 (35%)
		TM helix 3	91..121	CDD:320098	13/29 (45%)
		TM helix 4	133..153	CDD:320098	9/19 (47%)
		TM helix 5	182..379	CDD:320098	48/266 (18%)
		TM helix 6	380..410	CDD:320098	12/29 (41%)
		TM helix 7	420..445	CDD:320098	11/24 (46%)