Protein Alignment TyrR and ser-7

DIOPT Version :10

• Sequence 1: NP_650652.1
• Gene: TyrR / 42136
• FlyBaseID: FBgn0038542
• Length: 631
• Species: Drosophila melanogaster
• Sequence 2: NP_741730.1
• Gene: ser-7 / 180565
• WormBaseID: WBGene00004780
• Length: 435
• Species: Caenorhabditis elegans
• Alignment Length: 510
• Identity: 127/510 - (24%)
• Similarity: 197/510 - (38%)
• Gaps: 174/510 - (34%)

  Fly   115 QGIILIAVFATFIVVTVIGNTLVILAILTTRRLRTITNCFVMSLAVADLLVGIFVMPPAVAVHLI 179
            :.::.||:.| .|::|.:||.||.||:|..|:|:...|..::||||||..||:.|||.|:...|.
 Worm    41 KALLAIAILA-MIIMTTVGNALVCLAVLLVRKLKHPQNFLLVSLAVADFFVGLVVMPLALIDLLF 104

  Fly   180 GSWQLGWVLCDIWISLDVLLCTASILSLCAISVDRYLAVTRPLTYSRKRRSKRLALIMILIVWLL 244
            ..|.||..:|.::.:.|:.||||||::||||||||||.::.||.||.||.:||: ::.|..||::
 Worm   105 DKWPLGSTMCSVYTTSDLTLCTASIVNLCAISVDRYLVISSPLRYSAKRTTKRI-MMYIACVWII 168

  Fly   245 ALAITCPPML-------GWYEPGRRDLRECRYNQNEGYVIFSAMGSFFIPMAVMIYVYARISCVI 302
            |..::....:       |.|..   |...|:...:..|..::.:.||:.|..:|:.:..:|.
 Worm   169 AAIVSISSHIIANLLNDGTYVD---DTGTCQVIPHFIYQSYATIISFYAPTFIMVILNIKIW--- 227

  Fly   303 ASRHDNMTDISVHNKKFKRYTAADVENELSEQEQHSSVGQRQRQATSRTFSNQTIAKELQDMMLS 367
                          :..||..|                                     ||.::|
 Worm   228 --------------RAAKRLAA-------------------------------------QDRLMS 241

  Fly   368 DSDNCAAMGAGGAGGGGGGASSATGGTHCQSLLALPSGGVGGSMGCAKNGCYELTRPSSLKRAST 432
                                       ||.|:.|                       |...|..:
 Worm   242 ---------------------------HCNSVDA-----------------------SERPRNGS 256

  Fly   433 ASTTITTMTSGMGPGSSLLDAQWQSQPPGQTGQVQTHSLSQPPRTHSFRHSHGERDRERLRSHHH 497
            |.|            ...|:            :.:|..:.:..|.:|......:.:|:
 Worm   257 AET------------KDFLN------------EKETIDVPKKERANSTNSRLFKLERK------- 290

  Fly   498 HPHYHHQAGVTTTSTSGNTSANTNSKSLSNRITSLKKENKTTQTLSIVVGGFIACWLPFFINYLI 562
               |.|:.....::..|.....|.           |.|.|..:||.:::..||.|||||||
 Worm   291 ---YLHRPSAFFSAAKGPLIRQTE-----------KSECKARKTLGVIMSVFIICWLPFFI---- 337

  Fly   563 TPFLAEHQASQM-----LAKALTWLGWFNSAINPFIYAFYSVDFRAAFWR-LTCK 611
               ||..::..|     |.....|||:.||.:||.||..|:.:||..|.. |.|:
 Worm   338 ---LAIFKSFGMWIPDWLDLLALWLGYSNSTLNPLIYCKYNKEFRIPFREMLACR 389

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TyrR	NP_650652.1	7tmA_tyramine_R-like	118..>304	CDD:320189	71/192 (37%)
		TM helix 1	118..144	CDD:320189	12/25 (48%)
		TM helix 2	151..177	CDD:320189	13/25 (52%)
		TM helix 3	189..219	CDD:320189	18/29 (62%)
		TM helix 4	232..255	CDD:320189	5/29 (17%)
		TM helix 5	272..297	CDD:320189	5/24 (21%)
		7tm_GPCRs	<533..605	CDD:475119	30/76 (39%)
		TM helix 6	539..561	CDD:320189	11/21 (52%)
		TM helix 7	573..598	CDD:320189	11/29 (38%)
ser-7	NP_741730.1	7tmA_5-HT7	42..382	CDD:320452	124/500 (25%)
		TM helix 1	43..69	CDD:320452	12/26 (46%)
		TM helix 2	76..102	CDD:320452	13/25 (52%)
		TM helix 3	114..144	CDD:320452	18/29 (62%)
		TM helix 4	156..178	CDD:320452	6/22 (27%)
		TM helix 5	200..229	CDD:320452	6/45 (13%)
		TM helix 6	231..342	CDD:320452	39/249 (16%)
		TM helix 7	350..375	CDD:320452	10/24 (42%)