Protein Alignment TyrR and Htr7

DIOPT Version :10

• Sequence 1: NP_650652.1
• Gene: TyrR / 42136
• FlyBaseID: FBgn0038542
• Length: 631
• Species: Drosophila melanogaster
• Sequence 2: NP_001334371.1
• Gene: Htr7 / 15566
• MGIID: 99841
• Length: 470
• Species: Mus musculus
• Alignment Length: 571
• Identity: 141/571 - (24%)
• Similarity: 218/571 - (38%)
• Gaps: 201/571 - (35%)

  Fly    46 SIVYEDAGN-----GTGGGGVGGVGGGYPSGPNGTDAVALTEPGPT--APVTTFNYYNESAAAAE 103
            |::..:.|.     ...||....|....|...:|...|. ..|.||  ||....:...|...
Mouse    18 SLILPEVGRRLQDLSPDGGAHSVVSSWMPHLLSGFPEVT-ASPAPTWDAPPDNVSGCGEQIN--- 78

  Fly   104 WAHFYDLVLSWQGIILIAVFATFIVVTVIGNTLVILAILTTRRLRTITNCFVMSLAVADLLVGIF 168
                |..|   :.:::.::.....::|:.||.||::::...::||..:|..::|||:|||.|.:.
Mouse    79 ----YGRV---EKVVIGSILTLITLLTIAGNCLVVISVCFVKKLRQPSNYLIVSLALADLSVAVA 136

  Fly   169 VMPPAVAVHLI-GSWQLGWVLCDIWISLDVLLCTASILSLCAISVDRYLAVTRPLTYSRKRRSKR 232
            |||......|| |.|..|...|:::|::||:.|||||::||.||:||||.:||||||..::..|.
Mouse   137 VMPFVSVTDLIGGKWIFGHFFCNVFIAMDVMCCTASIMTLCVISIDRYLGITRPLTYPVRQNGKC 201

  Fly   233 LALIMILIVWLLALAITCPPMLGWYEPGRRDLRECRYNQNEGYVIFSAMGSFFIPMAVMIYVYAR 297
            :|. |||.||||:.:||.||:.||.: ...|.:.|..:|:.||.|:|...:|:|||:||:::|.:
Mouse   202 MAK-MILSVWLLSASITLPPLFGWAQ-NVNDDKVCLISQDFGYTIYSTAVAFYIPMSVMLFMYYQ 264

  Fly   298 ISCVIASRHDNMTDISVHNKKFKRYTAADVENELSEQEQHSSVGQRQRQATSRTFSNQTIAKELQ 362
            |                       |.||                  ::.|....||.....:.
Mouse   265 I-----------------------YKAA------------------RKSAAKHKFSGFPRVQP-- 286

  Fly   363 DMMLSDSDNCAAMGAGGAGGGGGGASSATGGTHCQSLLALPSGGVGGSMGCAKNGCYELTRPSSL 427
                                              :|:::|             ||..:|.:  .:
Mouse   287 ----------------------------------ESVISL-------------NGVVKLQK--EV 302

  Fly   428 KRASTASTTITTMTSGMGPGSSLLDAQWQSQPPGQTGQVQTHSLSQPPRTHSFRHSHGERDRERL 492
            :..:..|                                                        ||
Mouse   303 EECANLS--------------------------------------------------------RL 311

  Fly   493 RSHHHHPHYHHQAGVTTTSTSGNTSANTNSKSLSNRITSLKKENKTTQTLSIVVGGFIACWLPFF 557
            ..|..                             ..|:..|:|.|...||.|:||.|..||||||
Mouse   312 LKHER-----------------------------KNISIFKREQKAATTLGIIVGAFTVCWLPFF 347

  Fly   558 INYLITPFLAEHQASQM---LAKALTWLGWFNSAINPFIYAFYSVDFRAAF 605
            :.....||:.....|.:   :.:...|||:.||.||||||||::.|.|..:
Mouse   348 LLSTARPFICGTSCSCIPLWVERTCLWLGYANSLINPFIYAFFNRDLRTTY 398

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TyrR	NP_650652.1	7tmA_tyramine_R-like	118..>304	CDD:320189	76/186 (41%)
		TM helix 1	118..144	CDD:320189	5/25 (20%)
		TM helix 2	151..177	CDD:320189	11/25 (44%)
		TM helix 3	189..219	CDD:320189	17/29 (59%)
		TM helix 4	232..255	CDD:320189	12/22 (55%)
		TM helix 5	272..297	CDD:320189	11/24 (46%)
		7tm_GPCRs	<533..605	CDD:475119	33/74 (45%)
		TM helix 6	539..561	CDD:320189	12/21 (57%)
		TM helix 7	573..598	CDD:320189	13/27 (48%)
Htr7	NP_001334371.1	7tmA_5-HT7	100..398	CDD:320452	124/476 (26%)
		TM helix 2	119..145	CDD:320452	11/25 (44%)
		TM helix 3	158..188	CDD:320452	17/29 (59%)
		TM helix 4	200..222	CDD:320452	13/22 (59%)
		TM helix 5	239..268	CDD:320452	13/51 (25%)
		TM helix 6	323..353	CDD:320452	15/29 (52%)
		TM helix 7	366..391	CDD:320452	13/24 (54%)