Protein Alignment TyrR and Htr6

DIOPT Version :10

• Sequence 1: NP_650652.1
• Gene: TyrR / 42136
• FlyBaseID: FBgn0038542
• Length: 631
• Species: Drosophila melanogaster
• Sequence 2: NP_067333.1
• Gene: Htr6 / 15565
• MGIID: 1196627
• Length: 440
• Species: Mus musculus
• Alignment Length: 548
• Identity: 132/548 - (24%)
• Similarity: 187/548 - (34%)
• Gaps: 238/548 - (43%)

  Fly    82 EPGPTAPVTTFNYYNESAAA-----------AEWAHFYDLVLSWQGIILIAVFATFIVVTVIGNT 135
            ||||.         |.|..|           :.|              :.|.....||:|...|:
Mouse     4 EPGPV---------NSSTPAWGPGPPPAPGGSGW--------------VAAALCVVIVLTAAANS 45

  Fly   136 LVILAILTTRRLRTITNCFVMSLAVADLLVGIFVMPPAVAVHLIGSWQLGWVLCDIWISLDVLLC 200
            |:|..|.|...||..:|.|::||..:||:||:.|||||:...|.|.|.|...||.:|.:.||:.|
Mouse    46 LLIALICTQPALRNTSNFFLVSLFTSDLMVGLVVMPPAMLNALYGRWVLARGLCLLWTAFDVMCC 110

  Fly   201 TASILSLCAISVDRYLAVTRPLTYSRKRRSKRLALIMILIVW-LLALAITCPPMLGWYEPGRRDL 264
            :||||:||.||:||||.:..||.|..:..:.| ||.:||..| |.|||...|.:|||:|.|:...
Mouse   111 SASILNLCLISLDRYLLILSPLRYKLRMTAPR-ALALILGAWSLAALASFLPLLLGWHELGKART 174

  Fly   265 R---ECRYNQNEGYVIFSAMGSFFIPMAVMIYVYARISCVIASRHDNMTDISVHNKKFKRYTAAD 326
            .   :||...:..||:.::..:||:|...:.:.|.||  ::|:|
Mouse   175 SAPGQCRLLASLPYVLVASGVTFFLPSGAICFTYCRI--LLAAR--------------------- 216

  Fly   327 VENELSEQEQHSSVGQRQRQATSRTFSNQTIAKELQDMMLSDSDNCAAMGAGGAGGGGGGASSAT 391
                              :||..                                     .:|.|
Mouse   217 ------------------KQAVQ-------------------------------------VASLT 226

  Fly   392 GGTHCQSLLALPSGGVGGSMGCAKNGCYELTRPSSLKRASTASTTITTMTSGMGPGSSLLDAQWQ 456
            .||                                    :||...:.|:
Mouse   227 TGT------------------------------------ATAGQALETL---------------- 239

  Fly   457 SQPPGQTGQVQTHSLSQPPRTHSFRHSHGERDRERLRSHHHHPHYHHQAGVTTTSTSGNTSANTN 521
                            |.|||.  |......|..||.:.|.
Mouse   240 ----------------QVPRTP--RPGMESADSRRLTTKHS------------------------ 262

  Fly   522 SKSLSNRITSLKKENKTTQTLSIVVGGFIACWLPFFINYL-------ITPFLAEHQASQMLAKAL 579
                       :|..|.:.||.|::..|...|||||:..:       |:|.|.:         .|
Mouse   263 -----------RKALKASLTLGILLSMFFVTWLPFFVASIAQAVCDCISPGLFD---------VL 307

  Fly   580 TWLGWFNSAINPFIYAFYSVDFRAAFWR 607
            ||||:.||.:||.||..:..||:.|..|
Mouse   308 TWLGYCNSTMNPIIYPLFMRDFKRALGR 335

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TyrR	NP_650652.1	7tmA_tyramine_R-like	118..>304	CDD:320189	75/189 (40%)
		TM helix 1	118..144	CDD:320189	8/25 (32%)
		TM helix 2	151..177	CDD:320189	13/25 (52%)
		TM helix 3	189..219	CDD:320189	17/29 (59%)
		TM helix 4	232..255	CDD:320189	11/23 (48%)
		TM helix 5	272..297	CDD:320189	6/24 (25%)
		7tm_GPCRs	<533..605	CDD:475119	27/78 (35%)
		TM helix 6	539..561	CDD:320189	9/21 (43%)
		TM helix 7	573..598	CDD:320189	11/24 (46%)
Htr6	NP_067333.1	7tmA_5-HT6	29..333	CDD:320182	122/496 (25%)
		TM helix 1	29..54	CDD:320182	8/24 (33%)
		TM helix 2	61..87	CDD:320182	13/25 (52%)
		TM helix 3	99..129	CDD:320182	17/29 (59%)
		TM helix 4	141..164	CDD:320182	11/23 (48%)
		TM helix 5	185..214	CDD:320182	8/30 (27%)
		TM helix 6	263..293	CDD:320182	11/29 (38%)
		TM helix 7	301..326	CDD:320182	13/33 (39%)