Protein Alignment TyrR and Htr5a

DIOPT Version :10

• Sequence 1: NP_650652.1
• Gene: TyrR / 42136
• FlyBaseID: FBgn0038542
• Length: 631
• Species: Drosophila melanogaster
• Sequence 2: NP_032340.2
• Gene: Htr5a / 15563
• MGIID: 96283
• Length: 357
• Species: Mus musculus
• Alignment Length: 514
• Identity: 120/514 - (23%)
• Similarity: 186/514 - (36%)
• Gaps: 197/514 - (38%)

  Fly   107 FYDLVLSWQGIILIAVFATFIVVTVIGNTLVILAILTTRRLRTITNCFVMSLAVADLLVGIFVMP 171
            |..|||:..|.:..|.|.        .|.||:..||..|....:.:..|.|:|::|:||.:.|||
Mouse    39 FRVLVLTLLGFLAAATFT--------WNLLVLATILKVRTFHRVPHNLVASMAISDVLVAVLVMP 95

  Fly   172 PAVAVHLIG-SWQLGWVLCDIWISLDVLLCTASILSLCAISVDRYLAVTRPLTYSRKRRSKRLAL 235
            .::...|.| .||||..||.:||:.|||.|||||.::.||::|||.::||.|.|:.:.| ||::.
Mouse    96 LSLVHELSGRRWQLGRRLCQLWIACDVLCCTASIWNVTAIALDRYWSITRHLEYTLRTR-KRVSN 159

  Fly   236 IMILIVWLLALAITCPPML-GWYEPGRRDLRECRYNQNEGYVIFSAMGSFFIPMAVMIYVYARIS 299
            :|||:.|.|:..|:..|:| ||.|.......||:.::...|.:||.:|:|::|:.|:::||
Mouse   160 VMILLTWALSTVISLAPLLFGWGETYSEPSEECQVSREPSYTVFSTVGAFYLPLCVVLFVY---- 220

  Fly   300 CVIASRHDNMTDISVHNKKFKRYTAADVENELSEQEQHSSVGQRQRQATSRTFSNQTIAKELQDM 364
                               :|.|.||...
Mouse   221 -------------------WKIYRAAKFR------------------------------------ 230

  Fly   365 MLSDSDNCAAMGAGGAGGGGGGASSATGGTHCQSLLALPSGGVGGSMGCAKNGCYELTRPSSLKR 429
                                                          ||..|
Mouse   231 ----------------------------------------------MGSRK-------------- 235

  Fly   430 ASTASTTITTMTSGMGPGSSLLDAQWQSQPPGQTGQVQTHSLSQPPRTHSFRHSHGERDRERLRS 494
                       |:.:.|....::.:              ::...|....:.||:
Mouse   236 -----------TNSVSPVPEAVEVK--------------NATQHPQMVFTVRHA----------- 264

  Fly   495 HHHHPHYHHQAGVTTTSTSGNTSANTNSKSLSNRITSLKKENKTTQTLSIVVGGFIACWLPFFIN 559
                        ..|..|.|:|...             :||.:....:.|::|.|:.||.|||:.
Mouse   265 ------------TVTFQTEGDTWRE-------------QKEQRAALMVGILIGVFVLCWFPFFVT 304

  Fly   560 YLITPFLAEHQASQMLAKALTWLGWFNSAINPFIYAFYSVDFRAAFWRLTCKRFFSAGQ 618
            .||:| |.......:......|||:.||..||.||..::..:.:||     |.|||..|
Mouse   305 ELISP-LCSWDVPAIWKSIFLWLGYSNSFFNPLIYTAFNRSYSSAF-----KVFFSKQQ 357

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TyrR	NP_650652.1	7tmA_tyramine_R-like	118..>304	CDD:320189	69/187 (37%)
		TM helix 1	118..144	CDD:320189	7/25 (28%)
		TM helix 2	151..177	CDD:320189	9/25 (36%)
		TM helix 3	189..219	CDD:320189	16/29 (55%)
		TM helix 4	232..255	CDD:320189	9/23 (39%)
		TM helix 5	272..297	CDD:320189	9/24 (38%)
		7tm_GPCRs	<533..605	CDD:475119	23/71 (32%)
		TM helix 6	539..561	CDD:320189	8/21 (38%)
		TM helix 7	573..598	CDD:320189	9/24 (38%)
Htr5a	NP_032340.2	7tm_GPCRs	41..349	CDD:475119	112/497 (23%)
		TM helix 1	43..67	CDD:410628	9/31 (29%)
		TM helix 2	76..98	CDD:410628	9/21 (43%)
		TM helix 3	115..137	CDD:410628	12/21 (57%)
		TM helix 4	160..176	CDD:410628	6/15 (40%)
		TM helix 5	198..221	CDD:410628	9/45 (20%)
		TM helix 6	284..306	CDD:410628	8/21 (38%)
		TM helix 7	317..342	CDD:410628	9/24 (38%)