DRSC/TRiP Functional Genomics Resources

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Protein Alignment TyrR and Htr2c

DIOPT Version :10

Sequence 1:NP_650652.1 Gene:TyrR / 42136 FlyBaseID:FBgn0038542 Length:631 Species:Drosophila melanogaster
Sequence 2:NP_032338.3 Gene:Htr2c / 15560 MGIID:96281 Length:459 Species:Mus musculus


Alignment Length:552 Identity:128/552 - (23%)
Similarity:209/552 - (37%) Gaps:193/552 - (34%)


- Green bases have known domain annotations that are detailed below.


  Fly    85 PTAPVT--TFNYYNESAAAAEWAHFYDLVLSWQGIILIAVFATFIVVTVIGNTLVILAILTTRRL 147
            |.|.:.  |||    |:.......|.|.|.:|..:.::.:    |::|:.||.|||:|:...::|
Mouse    29 PVAAIVTDTFN----SSDGGRLFQFPDGVQNWPALSIVVI----IIMTIGGNILVIMAVSMEKKL 85

  Fly   148 RTITNCFVMSLAVADLLVGIFVMPPAVAVHLIG-SWQLGWVLCDIWISLDVLLCTASILSLCAIS 211
            ...||.|:||||:||:|||:.|||.::...|.. .|.|...||.:|||||||..||||:.|||||
Mouse    86 HNATNYFLMSLAIADMLVGLLVMPLSLLAILYDYVWPLPRYLCPVWISLDVLFSTASIMHLCAIS 150

  Fly   212 VDRYLAVTRPLTYSRKRRSKRLALIMILIVWLLALAITCP-PMLGWYEPGRRDLRE--CRYNQNE 273
            :|||:|:..|:.:|| ..|:..|::.|.|||.:::.::.| |::|..:..:..:..  |..| :.
Mouse   151 LDRYVAIRNPIEHSR-FNSRTKAIMKIAIVWAISIGVSVPIPVIGLRDESKVFVNNTTCVLN-DP 213

  Fly   274 GYVIFSAMGSFFIPMAVMIYVYARISCVIASRHDNMTDISVHNKKFKRYTAADVENELSEQEQHS 338
            .:|:..:..:||||:.:|:..|.....|:                                    
Mouse   214 NFVLIGSFVAFFIPLTIMVITYFLTIYVL------------------------------------ 242

  Fly   339 SVGQRQRQATSRTFSNQTIAKELQDMMLSDSDNCAAMGAGGAGGGGGGASSATGGTHCQSLLALP 403
                  |:.|.......| .:||:::.|:                         ...|       
Mouse   243 ------RRQTLMLLRGHT-EEELRNISLN-------------------------FLKC------- 268

  Fly   404 SGGVGGSMGCAKNGCYELTRPSSLKRASTASTTITTMTSGMGPGSSLLDAQWQSQPPGQTGQVQT 468
                     |.|.|..|...|:.                                          
Mouse   269 ---------CCKKGDEEENAPNP------------------------------------------ 282

  Fly   469 HSLSQPPRTHSFRHSHGERDRERLRSHHHHPHYHHQAGVTTTSTSGNTSANTNSKSLSNRITSLK 533
             :..|.||    |....:|.|..::                                     ::.
Mouse   283 -NPDQKPR----RKKKEKRPRGTMQ-------------------------------------AIN 305

  Fly   534 KENKTTQTLSIVVGGFIACWLPFFINYLITPFLAEHQASQMLAKAL---TWLGWFNSAINPFIYA 595
            .|.|.::.|.||...|:..|.||||..:::....:....:::.|.|   .|:|:..|.|||.:|.
Mouse   306 NEKKASKVLGIVFFVFLIMWCPFFITNILSVLCGKACNQKLMEKLLNVFVWIGYVCSGINPLVYT 370

  Fly   596 FYSVDFRAAFWR-LTCKRFFSAGQKP---QFP 623
            .::..:|.||.: |.|.  :...:||   |.|
Mouse   371 LFNKIYRRAFSKYLRCD--YKPDKKPPVRQIP 400

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
TyrRNP_650652.1 7tmA_tyramine_R-like 118..>304 CDD:320189 71/189 (38%)
TM helix 1 118..144 CDD:320189 8/25 (32%)
TM helix 2 151..177 CDD:320189 15/25 (60%)
TM helix 3 189..219 CDD:320189 21/29 (72%)
TM helix 4 232..255 CDD:320189 7/23 (30%)
TM helix 5 272..297 CDD:320189 7/24 (29%)
7tm_GPCRs <533..605 CDD:475119 21/74 (28%)
TM helix 6 539..561 CDD:320189 9/21 (43%)
TM helix 7 573..598 CDD:320189 9/27 (33%)
Htr2cNP_032338.3 7tmA_5-HT2C 55..386 CDD:341346 114/504 (23%)
TM helix 1 56..82 CDD:341346 9/29 (31%)
TM helix 2 89..115 CDD:341346 15/25 (60%)
TM helix 3 128..158 CDD:341346 21/29 (72%)
DRY motif, important for ligand-induced conformation changes. /evidence=ECO:0000250|UniProtKB:P41595 152..154 1/1 (100%)
TM helix 4 170..193 CDD:341346 7/22 (32%)
TM helix 5 212..241 CDD:341346 7/28 (25%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 274..302 8/74 (11%)
TM helix 6 305..335 CDD:341346 11/29 (38%)
TM helix 7 348..373 CDD:341346 9/24 (38%)
NPxxY motif, important for ligand-induced conformation changes and signaling. /evidence=ECO:0000250|UniProtKB:P41595 365..369 2/3 (67%)
PDZ-binding 457..459
Blue background indicates that the domain is not in the aligned region.

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