Protein Alignment TyrR and Htr2b

DIOPT Version :10

• Sequence 1: NP_650652.1
• Gene: TyrR / 42136
• FlyBaseID: FBgn0038542
• Length: 631
• Species: Drosophila melanogaster
• Sequence 2: XP_006529209.1
• Gene: Htr2b / 15559
• MGIID: 109323
• Length: 495
• Species: Mus musculus
• Alignment Length: 526
• Identity: 123/526 - (23%)
• Similarity: 201/526 - (38%)
• Gaps: 197/526 - (37%)

  Fly   114 WQGIILIAVFATFIVVTVIGNTLVILAILTTRRLRTITNCFVMSLAVADLLVGIFVMPPAVAVHL 178
            |..::::||    |:.|:.||.|||||:...:||:..||.|:||||:||||||:||||.|:...:
Mouse    55 WAALLILAV----IIPTIGGNILVILAVALEKRLQYATNYFLMSLAIADLLVGLFVMPIALLTIM 115

  Fly   179 IGS-WQLGWVLCDIWISLDVLLCTASILSLCAISVDRYLAVTRPLTYSRKRRSKRLALIMILIVW 242
            ..: |.|...||..|:.||||..||||:.|||||:|||:|:.:|: .:.:..|:..|.|.|.:||
Mouse   116 FEAIWPLPLALCPAWLFLDVLFSTASIMHLCAISLDRYIAIKKPI-QANQCNSRATAFIKITVVW 179

  Fly   243 LLALAITCPPMLGWYEPGRRDLR------------------ECRYNQNE--GYVIFSAMGSFFIP 287
            |:::.:...|:..:.:.....:.                  .|...::.  .:::|.::.:||.|
Mouse   180 LISIGMWGMPLFPYGQNASSGIAIPVPIKGIETDVINPHNVTCELTKDRFGSFMVFGSLAAFFAP 244

  Fly   288 MAVMIYVYARISCVIASRHDNMTDISVHNKKFKRYTAADVENELSEQEQHSSVGQRQRQATSRTF 352
            :.:|:..|.               :::|..:.|.|.   |:|:..::
Mouse   245 LTIMVVTYF---------------LTIHTLQKKAYL---VKNKPPQR------------------ 273

  Fly   353 SNQTIAKELQDMMLSDSDNCAAMGAGGAGGGGGGASSATGGTHCQSLLALPSGGVGGSMGCAKNG 417
                                                                             
Mouse   274 ----------------------------------------------------------------- 273

  Fly   418 CYELTR---PSSLKRASTASTTITTMTSGMGPGSSLLDAQWQSQPPGQTGQVQTHSLSQPPRTHS 479
               |||   |:...|                                     :..|.|.|.:...
Mouse   274 ---LTRWTVPTVFLR-------------------------------------EDSSFSSPEKVAM 298

  Fly   480 FRHSHGERDRERLRSHHHHPHYHHQAGVTTTSTSGNTSANTNSKSLSNRITSLKKENKTTQTLSI 544
            ...||    |:::.     |:...:..:...|:.|..||.|    :||       |.:.::.|.:
Mouse   299 LDGSH----RDKIL-----PNSSDETLMRRMSSVGKRSAQT----ISN-------EQRASKALGV 343

  Fly   545 VVGGFIACWLPFFINYLITPFLAEHQASQMLAKAL----TWLGWFNSAINPFIYAFYSVDFRAAF 605
            |...|:..|.||||..| |..|.: ..:|...|.|    .|:|:.:|.:||.||..::..||.||
Mouse   344 VFFLFLLMWCPFFITNL-TLALCD-SCNQTTLKTLLEIFVWIGYVSSGVNPLIYTLFNKTFREAF 406

  Fly   606 WR-LTC 610
            .| :||
Mouse   407 GRYITC 412

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TyrR	NP_650652.1	7tmA_tyramine_R-like	118..>304	CDD:320189	69/206 (33%)
		TM helix 1	118..144	CDD:320189	11/25 (44%)
		TM helix 2	151..177	CDD:320189	18/25 (72%)
		TM helix 3	189..219	CDD:320189	19/29 (66%)
		TM helix 4	232..255	CDD:320189	7/22 (32%)
		TM helix 5	272..297	CDD:320189	6/26 (23%)
		7tm_GPCRs	<533..605	CDD:475119	24/75 (32%)
		TM helix 6	539..561	CDD:320189	8/21 (38%)
		TM helix 7	573..598	CDD:320189	10/28 (36%)
Htr2b	XP_006529209.1	7tm_GPCRs	54..413	CDD:475119	123/526 (23%)
		TM helix 1	56..80	CDD:410628	11/27 (41%)
		TM helix 2	89..111	CDD:410628	16/21 (76%)
		TM helix 3	128..150	CDD:410628	13/21 (62%)
		TM helix 4	173..205	CDD:410628	6/31 (19%)
		TM helix 5	230..253	CDD:410628	5/22 (23%)
		TM helix 6	338..360	CDD:410628	8/21 (38%)
		TM helix 7	374..399	CDD:410628	9/24 (38%)