DRSC/TRiP Functional Genomics Resources

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Protein Alignment TyrR and Htr2a

DIOPT Version :10

Sequence 1:NP_650652.1 Gene:TyrR / 42136 FlyBaseID:FBgn0038542 Length:631 Species:Drosophila melanogaster
Sequence 2:NP_766400.1 Gene:Htr2a / 15558 MGIID:109521 Length:471 Species:Mus musculus


Alignment Length:516 Identity:118/516 - (22%)
Similarity:193/516 - (37%) Gaps:193/516 - (37%)


- Green bases have known domain annotations that are detailed below.


  Fly   113 SWQGIILIAVFATFIVVTVIGNTLVILAILTTRRLRTITNCFVMSLAVADLLVGIFVMPPAVAVH 177
            :|..::...|    |::|:.||.|||:|:...::|:..||.|:||||:||:|:|..|||.::...
Mouse    75 NWSALLTTVV----IILTIAGNILVIMAVSLEKKLQNATNYFLMSLAIADMLLGFLVMPVSMLTI 135

  Fly   178 LIG-SWQLGWVLCDIWISLDVLLCTASILSLCAISVDRYLAVTRPLTYSRKRRSKRLALIMILIV 241
            |.| .|.|...||.:||.||||..||||:.|||||:|||:|:..|:.:|| ..|:..|.:.|:.|
Mouse   136 LYGYRWPLPSKLCAVWIYLDVLFSTASIMHLCAISLDRYVAIQNPIHHSR-FNSRTKAFLKIIAV 199

  Fly   242 WLLALAITCP-PMLGWYEPGRRDLRECRYNQNEGYVIFSAMGSFFIPMAVMIYVYARISCVIASR 305
            |.:::.|:.| |:.|..:..:..........::.:|:..:..:||||:.:|:..|          
Mouse   200 WTISVGISMPIPVFGLQDDSKVFKEGSCLLADDNFVLIGSFVAFFIPLTIMVITY---------- 254

  Fly   306 HDNMTDISVHNKKFKRYTAADVENELSEQEQHSSVGQRQRQATSRTFSNQTIAKELQDMMLSDSD 370
                                           ..::...|::||               :.:||..
Mouse   255 -------------------------------FLTIKSLQKEAT---------------LCVSDLS 273

  Fly   371 NCAAMGAGGAGGGGGGASSATGGTHCQSLLALPSGGVGGSMGCAKNGCYELTRPSSLKRASTAST 435
            .                                                         ||..:|.
Mouse   274 T---------------------------------------------------------RAKLSSF 281

  Fly   436 TITTMTSGMGPGSSLLDAQWQSQPPGQTGQVQTHSLSQPPRTHSFRHSHGERDRERL--RSHHHH 498
            :..       |.|||                                     ..|:|  ||.|..
Mouse   282 SFL-------PQSSL-------------------------------------SSEKLFQRSIHRE 302

  Fly   499 PHYHHQAGVTTTSTSGNTSANTNSKSLSNRITSLKKENKTTQTLSIVVGGFIACWLPFFINYLIT 563
            |              |:.:.....:|:||       |.|..:.|.||...|:..|.||||..::.
Mouse   303 P--------------GSYAGRRTMQSISN-------EQKACKVLGIVFFLFVVMWCPFFITNIMA 346

  Fly   564 PFLAEHQASQMLAKAL---TWLGWFNSAINPFIYAFYSVDFRAAFWR-LTCKRFFSAGQKP 620
            ....|.....::...|   .|:|:.:||:||.:|..::..:|:||.| :.|:  :...:||
Mouse   347 VICKESCNENVIGALLNVFVWIGYLSSAVNPLVYTLFNKTYRSAFSRYIQCQ--YKENRKP 405

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
TyrRNP_650652.1 7tmA_tyramine_R-like 118..>304 CDD:320189 68/187 (36%)
TM helix 1 118..144 CDD:320189 9/25 (36%)
TM helix 2 151..177 CDD:320189 14/25 (56%)
TM helix 3 189..219 CDD:320189 20/29 (69%)
TM helix 4 232..255 CDD:320189 7/23 (30%)
TM helix 5 272..297 CDD:320189 7/24 (29%)
7tm_GPCRs <533..605 CDD:475119 21/74 (28%)
TM helix 6 539..561 CDD:320189 9/21 (43%)
TM helix 7 573..598 CDD:320189 8/27 (30%)
Htr2aNP_766400.1 7tmA_5-HT2A 75..391 CDD:341345 112/498 (22%)
TM helix 1 76..102 CDD:341345 10/29 (34%)
TM helix 2 109..135 CDD:341345 14/25 (56%)
TM helix 3 148..178 CDD:341345 20/29 (69%)
DRY motif, important for ligand-induced conformation changes. /evidence=ECO:0000250|UniProtKB:P41595 172..174 1/1 (100%)
TM helix 4 190..213 CDD:341345 7/22 (32%)
TM helix 5 231..260 CDD:341345 7/69 (10%)
TM helix 6 316..346 CDD:341345 13/36 (36%)
TM helix 7 359..384 CDD:341345 8/24 (33%)
NPxxY motif, important for ligand-induced conformation changes and signaling. /evidence=ECO:0000250|UniProtKB:P41595 376..380 2/3 (67%)
PDZ-binding. /evidence=ECO:0000250|UniProtKB:P28223 469..471
Blue background indicates that the domain is not in the aligned region.

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