Protein Alignment TyrR and Htr1f

DIOPT Version :10

• Sequence 1: NP_650652.1
• Gene: TyrR / 42136
• FlyBaseID: FBgn0038542
• Length: 631
• Species: Drosophila melanogaster
• Sequence 2: NP_032336.1
• Gene: Htr1f / 15557
• MGIID: 99842
• Length: 366
• Species: Mus musculus
• Alignment Length: 498
• Identity: 131/498 - (26%)
• Similarity: 202/498 - (40%)
• Gaps: 156/498 - (31%)

  Fly   117 IILIAVFATFIVVTVIGNTLVILAILTTRRLRTITNCFVMSLAVADLLVGIFVMPPAVAVHLIGS 181
            |::....:...::|...|:|||.||:.||:|....|..:.||||.|.||.:.|||.::...:..|
Mouse    24 ILVSLTLSGLALMTTTINSLVIAAIIVTRKLHHPANYLICSLAVTDFLVAVLVMPFSIVYIVRES 88

  Fly   182 WQLGWVLCDIWISLDVLLCTASILSLCAISVDRYLAVTRPLTYSRKRRSKRLALIMILIVWLLAL 246
            |.:|.||||||:|:|::.||.|||.|.||::|||.|:|..:.|:|| |:.|.|.|||.|||::::
Mouse    89 WIMGQVLCDIWLSVDIICCTCSILHLSAIALDRYRAITDAVEYARK-RTPRHAGIMITIVWVISV 152

  Fly   247 AITCPPMLGWYEPGRRDLRECRYNQNE-GYVIFSAMGSFFIPMAVMIYVYARISCVIASRHDNMT 310
            .|:.||:. |...|.....||....:. ...|:|..|:|:||:.:::.:|
Mouse   153 FISMPPLF-WRHQGTSRDDECVIKHDHIVSTIYSTFGAFYIPLVLILILY--------------- 201

  Fly   311 DISVHNKKFKRYTAADVENELSEQEQHSSVGQRQRQATSRTFSNQTIAKELQDMMLSDSDNCAAM 375
                    :|.|.||             .....:|||      ::.|.:||...:..:|..
Mouse   202 --------YKIYRAA-------------RTLYHKRQA------SRMIKEELNGQVFLESGE---- 235

  Fly   376 GAGGAGGGGGGASSATGGTHCQSLLALPSGGVGGSMGCAKNGCYELTRPSSLKRASTASTTITTM 440
                                                             .|:|..||
Mouse   236 -------------------------------------------------KSIKLVST-------- 243

  Fly   441 TSGMGPGSSLLDAQWQSQPPGQTGQVQTHSLSQPPRTHSFRHSHGERDRERLRSHHHHPHYHHQA 505
                   |.:|:                .|||.|.......||..:..|..|:
Mouse   244 -------SYMLE----------------KSLSDPSTDFDRIHSTVKSPRSELK------------ 273

  Fly   506 GVTTTSTSGNTSANTNSKSLSNRITSLKKENKTTQTLSIVVGGFIACWLPFFINYLITPFLAEHQ 570
                           :.||...:..|..:|.|...||.:::|.|:.||||||:..|:.....:.:
Mouse   274 ---------------HEKSWRRQKISGTRERKAATTLGLILGAFVICWLPFFVKELVVNVCEKCK 323

  Fly   571 ASQMLAKALTWLGWFNSAINPFIYAFYSVDFRAAFWRLTCKRF 613
            .|:.::..|.|||:.||.|||.||..::.||:.||.:|...|:
Mouse   324 ISEEMSNFLAWLGYLNSLINPLIYTIFNEDFKKAFQKLVRCRY 366

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TyrR	NP_650652.1	7tmA_tyramine_R-like	118..>304	CDD:320189	71/186 (38%)
		TM helix 1	118..144	CDD:320189	7/25 (28%)
		TM helix 2	151..177	CDD:320189	11/25 (44%)
		TM helix 3	189..219	CDD:320189	18/29 (62%)
		TM helix 4	232..255	CDD:320189	11/22 (50%)
		TM helix 5	272..297	CDD:320189	7/25 (28%)
		7tm_GPCRs	<533..605	CDD:475119	27/71 (38%)
		TM helix 6	539..561	CDD:320189	10/21 (48%)
		TM helix 7	573..598	CDD:320189	11/24 (46%)
Htr1f	NP_032336.1	7tmA_5-HT1F	24..359	CDD:320456	128/489 (26%)
		TM helix 1	25..51	CDD:320456	7/25 (28%)
		TM helix 2	58..84	CDD:320456	11/25 (44%)
		TM helix 3	96..126	CDD:320456	18/29 (62%)
		DRY motif, important for ligand-induced conformation changes. /evidence=ECO:0000250|UniProtKB:P41595	120..122		1/1 (100%)
		TM helix 4	138..160	CDD:320456	11/21 (52%)
		TM helix 5	178..207	CDD:320456	9/51 (18%)
		TM helix 6	286..316	CDD:320456	13/29 (45%)
		TM helix 7	326..351	CDD:320456	11/24 (46%)
		NPxxY motif, important for ligand-induced conformation changes and signaling. /evidence=ECO:0000250|UniProtKB:P41595	343..347		2/3 (67%)