Protein Alignment TyrR and Htr1d

DIOPT Version :10

• Sequence 1: NP_650652.1
• Gene: TyrR / 42136
• FlyBaseID: FBgn0038542
• Length: 631
• Species: Drosophila melanogaster
• Sequence 2: NP_032335.2
• Gene: Htr1d / 15552
• MGIID: 96276
• Length: 374
• Species: Mus musculus
• Alignment Length: 506
• Identity: 135/506 - (26%)
• Similarity: 197/506 - (38%)
• Gaps: 176/506 - (34%)

  Fly   111 VLSWQGIILIAVFATFIVVTVIGNTLVILAILTTRRLRTITNCFVMSLAVADLLVGIFVMPPAVA 175
            ||....|.|:.|.:...:.||:.|..|:..||.|::|.|..|..:.|||..||||.|.|||.::|
Mouse    30 VLQALRISLVVVLSVITLATVLSNAFVLTTILLTKKLHTPANYLIGSLATTDLLVSILVMPISIA 94

  Fly   176 VHLIGSWQLGWVLCDIWISLDVLLCTASILSLCAISVDRYLAVTRPLTYSRKRRSKRLALIMILI 240
            .....:|..|.:|||||:|.|:..||||||.||.|::|||.|:|..|.|| |||:...|..||..
Mouse    95 YTTTRTWNFGQILCDIWVSSDITCCTASILHLCVIALDRYWAITDALEYS-KRRTAGHAAAMIAA 158

  Fly   241 VWLLALAITCPPMLGWYEPGRRDLRECRYNQNE-GYVIFSAMGSFFIPMAVMIYVYARISCVIAS 304
            ||::::.|:.||:.........::.:|..|.:: .|.|:|..|:|:||..::|.:|.||  .:|:
Mouse   159 VWIISICISIPPLFWRQATAHEEMSDCLVNTSQISYTIYSTCGAFYIPSILLIILYGRI--YVAA 221

  Fly   305 RHDNMTDISVHNKKFKRYTAADVENELSEQEQHSSVGQRQRQATSRTFSNQTIAKELQDMMLSDS 369
            |...:...|::.|:|                                    |.|:
Mouse   222 RSRILNPPSLYGKRF------------------------------------TTAQ---------- 240

  Fly   370 DNCAAMGAGGAGGGGGGASSATGGTHCQSLLALPSGGVGGSMGCAKNGCYELTRPSSLKRASTAS 434
                                            |.:|..|.|: |:.|
Mouse   241 --------------------------------LITGSAGSSL-CSLN------------------ 254

  Fly   435 TTITTMTSGMGPGSSLLDAQWQSQPPGQTGQVQTHSLSQPPRTHSFRHSHGERDRERLRSHHH-- 497
                                                    |..|              .||.|
Mouse   255 ----------------------------------------PSLH--------------ESHTHTV 265

  Fly   498 -HPHYHHQAGVTTTSTSGNTSANTNSKSLSNRITSLKKENKTTQTLSIVVGGFIACWLPFFINYL 561
             .|.:.:|..:....:           .|..:..|..:|.|.|:||.|::|.||.||||||:..|
Mouse   266 GSPLFFNQVKIKLADS-----------ILERKRISAARERKATKTLGIILGAFIICWLPFFVVSL 319

  Fly   562 ITPFLAE----HQASQMLAKALTWLGWFNSAINPFIYAFYSVDFRAAFWRL 608
            :.|...:    |.|   |....||||:.||.|||.||..::.|||.||.::
Mouse   320 VLPICRDSCWIHPA---LFDFFTWLGYLNSLINPVIYTVFNEDFRQAFQKV 367

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TyrR	NP_650652.1	7tmA_tyramine_R-like	118..>304	CDD:320189	74/186 (40%)
		TM helix 1	118..144	CDD:320189	8/25 (32%)
		TM helix 2	151..177	CDD:320189	13/25 (52%)
		TM helix 3	189..219	CDD:320189	19/29 (66%)
		TM helix 4	232..255	CDD:320189	8/22 (36%)
		TM helix 5	272..297	CDD:320189	9/25 (36%)
		7tm_GPCRs	<533..605	CDD:475119	34/75 (45%)
		TM helix 6	539..561	CDD:320189	13/21 (62%)
		TM helix 7	573..598	CDD:320189	12/24 (50%)
Htr1d	NP_032335.2	7tm_GPCRs	32..364	CDD:475119	131/499 (26%)
		TM helix 1	38..62	CDD:320455	7/23 (30%)
		TM helix 2	71..93	CDD:320455	12/21 (57%)
		TM helix 3	109..131	CDD:320455	14/21 (67%)
		DRY motif, important for ligand-induced conformation changes. /evidence=ECO:0000250|UniProtKB:P41595	132..134		1/1 (100%)
		TM helix 4	154..170	CDD:320455	5/15 (33%)
		TM helix 5	192..215	CDD:320455	8/22 (36%)
		TM helix 6	297..319	CDD:320455	13/21 (62%)
		TM helix 7	332..357	CDD:320455	13/27 (48%)
		NPxxY motif, important for ligand-induced conformation changes and signaling. /evidence=ECO:0000250|UniProtKB:P41595	349..353		2/3 (67%)