Protein Alignment TyrR and ADRB3

DIOPT Version :10

• Sequence 1: NP_650652.1
• Gene: TyrR / 42136
• FlyBaseID: FBgn0038542
• Length: 631
• Species: Drosophila melanogaster
• Sequence 2: NP_000016.1
• Gene: ADRB3 / 155
• HGNCID: 288
• Length: 408
• Species: Homo sapiens
• Alignment Length: 553
• Identity: 146/553 - (26%)
• Similarity: 213/553 - (38%)
• Gaps: 208/553 - (37%)

  Fly    72 PNGTDAVALTEPGPTAPVTTFNYYNESAAAAEWAHFYDLVLSWQGIILIAVFATFIVVTVIGNTL 136
            |:...::|   |.|..|....|..|.|....         :.|:..:..|:.|..::.||.||.|
Human     5 PHENSSLA---PWPDLPTLAPNTANTSGLPG---------VPWEAALAGALLALAVLATVGGNLL 57

  Fly   137 VILAILTTRRLRTITNCFVMSLAVADLLVGIFVMPPAVAVHLIGSWQLGWVLCDIWISLDVLLCT 201
            ||:||..|.||:|:||.||.|||.|||::|:.|:|||..:.|.|.|.||...|::|.|:|||..|
Human    58 VIVAIAWTPRLQTMTNVFVTSLAAADLVMGLLVVPPAATLALTGHWPLGATGCELWTSVDVLCVT 122

  Fly   202 ASILSLCAISVDRYLAVTRPLTYSRKRRSKRLALIMILIVWLLALAITCPPMLG-WYEPG----- 260
            |||.:|||::||||||||.||.|. ...:||.|...:::||:::.|::..|::. |:..|
Human   123 ASIETLCALAVDRYLAVTNPLRYG-ALVTKRCARTAVVLVWVVSAAVSFAPIMSQWWRVGADAEA 186

  Fly   261 ---RRDLRECRYNQNEGYVIFSAMGSFFIPMAVMIYVYARISCVIASRHDNMTDISVHNKKFKRY 322
               ..:.|.|.:..|..||:.|:..||::|:.||::||||: .|:|:|...:
Human   187 QRCHSNPRCCAFASNMPYVLLSSSVSFYLPLLVMLFVYARV-FVVATRQLRL------------- 237

  Fly   323 TAADVENELSEQEQHSSVGQRQRQATSRTFSNQTIAKELQDMMLSDSDNCAAMGAGGAGGGGGGA 387
                :..||.......|     ..|.||:.:...:.            .||
Human   238 ----LRGELGRFPPEES-----PPAPSRSLAPAPVG------------TCA-------------- 267

  Fly   388 SSATGGTHCQSLLALPSGGVGGSMGCAKNGCYELTRPSSLKRASTASTTITTMTSGMGPGSSLLD 452
                           |..||   ..|.:       ||:
Human   268 ---------------PPEGV---PACGR-------RPA--------------------------- 280

  Fly   453 AQWQSQPPGQTGQVQTHSLSQPPRTHSFRHSHGERDRERLRSHHHHPHYHHQAGVTTTSTSGNTS 517
                                                                             
Human   281 ----------------------------------------------------------------- 280

  Fly   518 ANTNSKSLSNRITSLKKENKTTQTLSIVVGGFIACWLPFFINYLIT----PFLAEHQASQMLAKA 578
                      |:..| :|::...||.:::|.|..||||||:..::.    |.|....|    ..|
Human   281 ----------RLLPL-REHRALCTLGLIMGTFTLCWLPFFLANVLRALGGPSLVPGPA----FLA 330

  Fly   579 LTWLGWFNSAINPFIYAFYSVDFRAAFWRLTCK 611
            |.|||:.|||.||.||. .|.|||:||.||.|:
Human   331 LNWLGYANSAFNPLIYC-RSPDFRSAFRRLLCR 362

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TyrR	NP_650652.1	7tmA_tyramine_R-like	118..>304	CDD:320189	84/194 (43%)
		TM helix 1	118..144	CDD:320189	11/25 (44%)
		TM helix 2	151..177	CDD:320189	15/25 (60%)
		TM helix 3	189..219	CDD:320189	19/29 (66%)
		TM helix 4	232..255	CDD:320189	6/22 (27%)
		TM helix 5	272..297	CDD:320189	11/24 (46%)
		7tm_GPCRs	<533..605	CDD:475119	30/75 (40%)
		TM helix 6	539..561	CDD:320189	10/21 (48%)
		TM helix 7	573..598	CDD:320189	12/24 (50%)
ADRB3	NP_000016.1	7tm_GPCRs	51..356	CDD:475119	130/487 (27%)
		TM helix 2	73..95	CDD:320625	13/21 (62%)
		TM helix 3	111..133	CDD:320625	12/21 (57%)
		TM helix 4	156..172	CDD:320625	3/15 (20%)
		TM helix 5	202..225	CDD:320625	9/22 (41%)
		TM helix 6	291..313	CDD:320625	10/21 (48%)
		TM helix 7	325..350	CDD:320625	13/29 (45%)