Protein Alignment TyrR and Hrh2

DIOPT Version :10

• Sequence 1: NP_650652.1
• Gene: TyrR / 42136
• FlyBaseID: FBgn0038542
• Length: 631
• Species: Drosophila melanogaster
• Sequence 2: NP_001399939.1
• Gene: Hrh2 / 15466
• MGIID: 108482
• Length: 421
• Species: Mus musculus
• Alignment Length: 576
• Identity: 128/576 - (22%)
• Similarity: 188/576 - (32%)
• Gaps: 269/576 - (46%)

  Fly    72 PNGT------DAVALTEPGPTAPVTTFNYYNESAAAAEWAHFYDLVLSWQGIILIAVFATFIVVT 130
            ||||      |::||.                                   :.:..|..|.|.:|
Mouse     3 PNGTVHSCCLDSIALK-----------------------------------VTISVVLTTLIFIT 32

  Fly   131 VIGNTLVILAILTTRRLRTITNCFVMSLAVADLLVGIFVMPPAVAVHLIGSWQLGWVLCDIWISL 195
            |.||.:|.||:...||||::||||::|||..|||:|:.|||.:....|...|..|.|.|:|:.||
Mouse    33 VAGNVVVCLAVSLNRRLRSLTNCFIVSLAATDLLLGLLVMPFSAIYQLSFKWSFGQVFCNIYTSL 97

  Fly   196 DVLLCTASILSLCAISVDRYLAVTRPLTYSRKRRSKRLALIMILIVWLLALAITCPPM-LGWYE- 258
            ||:|||||||:|..||:|||.|||.||.|.......|:| |.::.:|::::.::...: |||..
Mouse    98 DVMLCTASILNLFMISLDRYCAVTDPLRYPVLVTPVRVA-ISLVFIWVISITLSFLSIHLGWNSR 161

  Fly   259 ---PGRRDLRECRYNQNEGYVIFSAMGSFFIPMAVMIYVYARISCVIASRHDNMTDISVHNKKFK 320
               .|..|..:|:...||.|.:...|.:|::|:.:|...|.||                    ||
Mouse   162 NGTRGGNDTFKCKVQVNEVYGLVDGMVTFYLPLLIMCVTYYRI--------------------FK 206

  Fly   321 RYTAADVENELSEQEQHSSVGQRQRQATSRTFSNQTIAKELQDMMLSDSDNCAAMGAGGAGGGGG 385
                                                ||:|
Mouse   207 ------------------------------------IARE------------------------- 210

  Fly   386 GASSATGGTHCQSLLALPSGGVGGSMGCAKNGCYELTRPSSLKRASTASTTITTMTSGMGPGSSL 450
                                                    ..||.
Mouse   211 ----------------------------------------QAKRI-------------------- 215

  Fly   451 LDAQWQSQPPGQTGQVQTHSLSQPPRTHSFRHSHGERDRERLRSHHHHPHYHHQAGVTTTSTSGN 515
                                                                             
Mouse   216 ----------------------------------------------------------------- 215

  Fly   516 TSANTNSKSLSNRITSLK----KENKTTQTLSIVVGGFIACWLPFFINYLITPFLAEHQASQMLA 576
                       |.|:|.|    :|:|.|.||:.|:|.||.||.|:|..::......:...::::.
Mouse   216 -----------NHISSWKAATIREHKATVTLAAVMGAFIVCWFPYFTAFVYRGLRGDDAVNEVVE 269

  Fly   577 KALTWLGWFNSAINPFIYAFYSVDFRAAFWRL-TCKRFFSAGQKPQFPTNTMSIRR 631
            ..:.|||:.|||:||.:||..:.|||.|:.:| .||.......|.....|...:.|
Mouse   270 GIVLWLGYANSALNPILYATLNRDFRMAYQQLFHCKLASHNSHKTSLRLNNSLLSR 325

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TyrR	NP_650652.1	7tmA_tyramine_R-like	118..>304	CDD:320189	77/190 (41%)
		TM helix 1	118..144	CDD:320189	10/25 (40%)
		TM helix 2	151..177	CDD:320189	14/25 (56%)
		TM helix 3	189..219	CDD:320189	20/29 (69%)
		TM helix 4	232..255	CDD:320189	4/23 (17%)
		TM helix 5	272..297	CDD:320189	8/24 (33%)
		7tm_GPCRs	<533..605	CDD:475119	27/75 (36%)
		TM helix 6	539..561	CDD:320189	11/21 (52%)
		TM helix 7	573..598	CDD:320189	10/24 (42%)
Hrh2	NP_001399939.1	7tmA_Histamine_H2R	19..298	CDD:320179	114/496 (23%)
		TM helix 1	20..46	CDD:320179	10/25 (40%)
		TM helix 2	53..80	CDD:320179	14/26 (54%)
		TM helix 3	91..121	CDD:320179	20/29 (69%)
		TM helix 4	133..153	CDD:320179	4/20 (20%)
		TM helix 5	178..208	CDD:320179	12/85 (14%)
		TM helix 6	226..256	CDD:320179	13/29 (45%)
		TM helix 7	266..291	CDD:320179	10/24 (42%)