DRSC/TRiP Functional Genomics Resources

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Protein Alignment TyrR and Hrh1

DIOPT Version :9

Sequence 1:NP_001287381.1 Gene:TyrR / 42136 FlyBaseID:FBgn0038542 Length:631 Species:Drosophila melanogaster
Sequence 2:NP_001239571.1 Gene:Hrh1 / 15465 MGIID:107619 Length:488 Species:Mus musculus


Alignment Length:543 Identity:137/543 - (25%)
Similarity:228/543 - (41%) Gaps:142/543 - (26%)


- Green bases have known domain annotations that are detailed below.


  Fly   119 LIAVFATFIVVTVIGNTLVILAILTTRRLRTITNCFVMSLAVADLLVGIFVMPPAVAVHLIGSWQ 183
            |:.|.::..:|||..|.||:.|:.:.|:|.|:.|.:::||:||||:||..|||..:...::..|.
Mouse    30 LVVVLSSISLVTVGLNLLVLYAVRSERKLHTVGNLYIVSLSVADLIVGAVVMPMNILYLIMTKWS 94

  Fly   184 LGWVLCDIWISLDVLLCTASILSLCAISVDRYLAVTRPLTYSRKRRSKRLALIMILIVWLLALAI 248
            ||..||..|:|:|.:..||||.|:..:.:|||.:|.:||.|.| .|:|..|...||..|.|:. :
Mouse    95 LGRPLCLFWLSMDYVASTASIFSVFILCIDRYRSVQQPLRYLR-YRTKTRASATILGAWFLSF-L 157

  Fly   249 TCPPMLGW--YEPGRRDLRE--CR---YNQNEGYVIFSAMGSFFIPMAVMIYVYARISCVIA--S 304
            ...|:|||  :.|...:|||  |.   ||.. .:.|.:|:.:|::|..:|::.|.:|...:.  .
Mouse   158 WVIPILGWHHFTPLAPELREDKCETDFYNVT-WFKIMTAIINFYLPTLLMLWFYVKIYKAVRRHC 221

  Fly   305 RHDNMTDISVHNKKFKRYTAADVENELSEQEQHSSVGQRQR------------------QATSRT 351
            :|..:|:.|:......:..:.|.:....:..:.|..|.::|                  :.||.|
Mouse   222 QHRQLTNGSLPTFLEIKLRSEDAKEGAKKPGKESPWGVQKRPSRDPTGGLDQKSTSEDPKVTSPT 286

  Fly   352 FSNQTIAKEL-------QDMMLSDSDNCAAMGAGGAGGGGGGASSATGGTHCQSLLALPSGGVGG 409
            ..:|...:|.       .|:|.:.                                .:|.|...|
Mouse   287 VFSQEGERETVTRPCFRLDVMQTQ--------------------------------PVPEGDARG 319

  Fly   410 SMGCAKNGCYELTRP-------SSLKRASTASTTITTMTSGMGPGSSLLDAQWQSQ--------P 459
            |    |.....|::|       |:.:|.|..|...|           |:|.|..|:        .
Mouse   320 S----KANDQTLSQPKMDEQSLSTCRRISETSEDQT-----------LVDRQSFSRTTDSDTSIE 369

  Fly   460 PGQTGQVQTHSLSQPPRTHSFRHSHG----ERDRERLRSHHHHPHYHHQAGVTTTSTSGNTSANT 520
            || .|:|:..|          |.:.|    :...:|||||..    .:.:|:             
Mouse   370 PG-LGKVKARS----------RSNSGLDYIKVTWKRLRSHSR----QYVSGL------------- 406

  Fly   521 NSKSLSNRITSLKKENKTTQTLSIVVGGFIACWLPFFINYLITPFLAEHQASQMLAKALTWLGWF 585
                      .|.:|.|..:.|..::..||.||:|:||.:::..| .....|:.:.....|||:.
Mouse   407 ----------HLNRERKAAKQLGCIMAAFILCWIPYFIFFMVIAF-CNSCCSEPVHMFTIWLGYI 460

  Fly   586 NSAINPFIYAFYSVDFRAAFWRL 608
            ||.:||.||...:.:|:..|.::
Mouse   461 NSTLNPLIYPLCNENFKKTFKKI 483

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
TyrRNP_001287381.1 7tm_4 127..>249 CDD:304433 50/121 (41%)
7tm_1 133..>298 CDD:278431 64/171 (37%)
Hrh1NP_001239571.1 7tmA_Histamine_H1R 29..480 CDD:320178 136/538 (25%)
TM helix 1 29..55 CDD:320178 9/24 (38%)
TM helix 2 62..88 CDD:320178 12/25 (48%)
TM helix 3 100..130 CDD:320178 12/29 (41%)
Important for agonist binding. /evidence=ECO:0000250 107..112 1/4 (25%)
TM helix 4 142..163 CDD:320178 6/21 (29%)
TM helix 5 187..216 CDD:320178 7/29 (24%)
TM helix 6 218..439 CDD:320178 54/305 (18%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 245..337 17/127 (13%)
Important for agonist binding. /evidence=ECO:0000250 425..429 2/3 (67%)
TM helix 7 448..473 CDD:320178 9/24 (38%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 1 0.950 - 0 Normalized mean entropy S6630
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
21.860

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