DRSC/TRiP Functional Genomics Resources

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Protein Alignment TyrR and ADRB1

DIOPT Version :10

Sequence 1:NP_650652.1 Gene:TyrR / 42136 FlyBaseID:FBgn0038542 Length:631 Species:Drosophila melanogaster
Sequence 2:NP_000675.1 Gene:ADRB1 / 153 HGNCID:285 Length:477 Species:Homo sapiens


Alignment Length:590 Identity:151/590 - (25%)
Similarity:224/590 - (37%) Gaps:207/590 - (35%)


- Green bases have known domain annotations that are detailed below.


  Fly    58 GGGVGGVGGGYPSG-------PNG--TDAVALTEPGPTAPVTTFNYYNESAAAAEWAHFYDLVLS 113
            |.||..:|...|..       |:|  |.|..|....|.|.:......:....:.:|.       :
Human     2 GAGVLVLGASEPGNLSSAAPLPDGAATAARLLVPASPPASLLPPASESPEPLSQQWT-------A 59

  Fly   114 WQGIILIAVFATFIVVTVIGNTLVILAILTTRRLRTITNCFVMSLAVADLLVGIFVMPPAVAVHL 178
            ..|:::    |..:::.|.||.|||:||..|.||:|:||.|:||||.|||::|:.|:|....:.:
Human    60 GMGLLM----ALIVLLIVAGNVLVIVAIAKTPRLQTLTNLFIMSLASADLVMGLLVVPFGATIVV 120

  Fly   179 IGSWQLGWVLCDIWISLDVLLCTASILSLCAISVDRYLAVTRPLTY-SRKRRSKRLALIMILIVW 242
            .|.|:.|...|::|.|:|||..||||.:||.|::|||||:|.|..| |...|::...|  :..||
Human   121 WGRWEYGSFFCELWTSVDVLCVTASIETLCVIALDRYLAITSPFRYQSLLTRARARGL--VCTVW 183

  Fly   243 LL-ALAITCPPMLGWYEPGRRDLRECRYNQ--------NEGYVIFSAMGSFFIPMAVMIYVYARI 298
            .: ||....|.::.|:.....:.|.| ||.        |..|.|.|::.||::|:.:|.:||.|:
Human   184 AISALVSFLPILMHWWRAESDEARRC-YNDPKCCDFVTNRAYAIASSVVSFYVPLCIMAFVYLRV 247

  Fly   299 SCVIASRHDNMTDISVHNKKFKRYTAADVENELSEQEQHSSVGQRQRQATSRTFSNQTIAKELQD 363
                                |:                     :.|:|           .|::  
Human   248 --------------------FR---------------------EAQKQ-----------VKKI-- 258

  Fly   364 MMLSDSDNCAAMGAGGAGGGGGGASSATGGTHCQSLLALPSGGVGGSMGCAKNGCYELTRPSSLK 428
                  |:|.....||.                                         .||.|  
Human   259 ------DSCERRFLGGP-----------------------------------------ARPPS-- 274

  Fly   429 RASTASTTITTMTSGMGPGSSLLDAQWQSQPPGQTGQVQTHSLSQPPRTHSFRHSHGERDRERLR 493
                             |..|.:.|  .:.|||            |||                 
Human   275 -----------------PSPSPVPA--PAPPPG------------PPR----------------- 291

  Fly   494 SHHHHPHYHHQAGVTTTSTSGNTSANTNSKSLSNRITSLKKENKTTQTLSIVVGGFIACWLPFFI 558
                      .|....|:...|..|   .|...:|:.:| :|.|..:||.|::|.|..||||||:
Human   292 ----------PAAAAATAPLANGRA---GKRRPSRLVAL-REQKALKTLGIIMGVFTLCWLPFFL 342

  Fly   559 NYLITPFLAEHQASQMLAKALTWLGWFNSAINPFIYAFYSVDFRAAFWRLTC-------KRFFSA 616
            ..::..|..|....::.. ...|||:.|||.||.||. .|.|||.||..|.|       :|..:.
Human   343 ANVVKAFHRELVPDRLFV-FFNWLGYANSAFNPIIYC-RSPDFRKAFQGLLCCARRAARRRHATH 405

  Fly   617 GQKPQ 621
            |.:|:
Human   406 GDRPR 410

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
TyrRNP_650652.1 7tmA_tyramine_R-like 118..>304 CDD:320189 74/195 (38%)
TM helix 1 118..144 CDD:320189 9/25 (36%)
TM helix 2 151..177 CDD:320189 13/25 (52%)
TM helix 3 189..219 CDD:320189 18/29 (62%)
TM helix 4 232..255 CDD:320189 6/23 (26%)
TM helix 5 272..297 CDD:320189 10/24 (42%)
7tm_GPCRs <533..605 CDD:475119 29/71 (41%)
TM helix 6 539..561 CDD:320189 11/21 (52%)
TM helix 7 573..598 CDD:320189 10/24 (42%)
ADRB1NP_000675.1 7tmA_Beta1_AR 59..387 CDD:320624 131/501 (26%)
TM helix 1 60..86 CDD:320624 10/29 (34%)
TM helix 2 93..120 CDD:320624 13/26 (50%)
TM helix 3 131..161 CDD:320624 18/29 (62%)
TM helix 4 175..193 CDD:320624 5/19 (26%)
TM helix 5 221..253 CDD:320624 12/72 (17%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 269..307 16/141 (11%)
TM helix 6 317..347 CDD:320624 14/30 (47%)
TM helix 7 356..381 CDD:320624 10/26 (38%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 403..477 2/8 (25%)
PDZ-Binding 474..477
Blue background indicates that the domain is not in the aligned region.

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