DRSC/TRiP Functional Genomics Resources

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Protein Alignment TyrR and ADRA2B

DIOPT Version :10

Sequence 1:NP_650652.1 Gene:TyrR / 42136 FlyBaseID:FBgn0038542 Length:631 Species:Drosophila melanogaster
Sequence 2:NP_000673.2 Gene:ADRA2B / 151 HGNCID:282 Length:450 Species:Homo sapiens


Alignment Length:520 Identity:153/520 - (29%)
Similarity:226/520 - (43%) Gaps:105/520 - (20%)


- Green bases have known domain annotations that are detailed below.


  Fly   113 SWQGIILIAVFATFIVV-TVIGNTLVILAILTTRRLRTITNCFVMSLAVADLLVGIFVMPPAVAV 176
            |.|....||...||::: |:.||.|||||:||:|.||...|.|::|||.||:||...::|.::|.
Human     8 SVQATAAIAAAITFLILFTIFGNALVILAVLTSRSLRAPQNLFLVSLAAADILVATLIIPFSLAN 72

  Fly   177 HLIGSWQLGWVLCDIWISLDVLLCTASILSLCAISVDRYLAVTRPLTYSRKRRSKRLALIMILIV 241
            .|:|.|......|:::::||||.||:||:.|||||:|||.||:|.|.|:.||..:|:..| ||.|
Human    73 ELLGYWYFRRTWCEVYLALDVLFCTSSIVHLCAISLDRYWAVSRALEYNSKRTPRRIKCI-ILTV 136

  Fly   242 WLLALAITCPPML--GWYEPGRRDLRECRYNQNEGYVIFSAMGSFFIPMAVMIYVYARISCVIAS 304
            ||:|..|:.||::  |...|..|...:|:.||...|::.|::||||.|..:||.||.|| .:||.
Human   137 WLIAAVISLPPLIYKGDQGPQPRGRPQCKLNQEAWYILASSIGSFFAPCLIMILVYLRI-YLIAK 200

  Fly   305 RHDNMTDISVHNKKFKRYTAADVENELSEQEQHSSVGQRQRQATSRTFSNQTIAKELQDMMLSDS 369
            |                                               ||:              
Human   201 R-----------------------------------------------SNR-------------- 204

  Fly   370 DNCAAMGAGGAGGGGGGASSATGGTHCQSLLALPSGGVGGSMGCAKNGCYELTRPSSLKRASTAS 434
                 .|....||.|.|.|......|            ||::..||  ...|...:|.:..:..|
Human   205 -----RGPRAKGGPGQGESKQPRPDH------------GGALASAK--LPALASVASAREVNGHS 250

  Fly   435 TTITTMTSGMGP---GSSLLDAQWQSQPPGQTGQVQTHSL-SQPPRTHSFRHSHGERDRERLR-- 493
            .:......|..|   |:..|...|.:.|  .:||.|...: ...|...:......|.:.|...  
Human   251 KSTGEKEEGETPEDTGTRALPPSWAALP--NSGQGQKEGVCGASPEDEAEEEEEEEEEEEECEPQ 313

  Fly   494 -------SHHHHPHYHHQAGVTTTSTSGNTSANTNSKSLS----NRITSLKKENKTTQTLSIVVG 547
                   |....|....|......:..|.........::.    .|...|.:|.:.|..|::|:|
Human   314 AVPVSPASACSPPLQQPQGSRVLATLRGQVLLGRGVGAIGGQWWRRRAQLTREKRFTFVLAVVIG 378

  Fly   548 GFIACWLPFFINYLITPFLAEH-QASQMLAKALTWLGWFNSAINPFIYAFYSVDFRAAFWRLTCK 611
            .|:.||.|||.:|.:.....:| :....|.:...|:|:.||::||.||..::.|||.||.|:.|:
Human   379 VFVLCWFPFFFSYSLGAICPKHCKVPHGLFQFFFWIGYCNSSLNPVIYTIFNQDFRRAFRRILCR 443

  Fly   612  611
            Human   444  443

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
TyrRNP_650652.1 7tmA_tyramine_R-like 118..>304 CDD:320189 86/188 (46%)
TM helix 1 118..144 CDD:320189 13/26 (50%)
TM helix 2 151..177 CDD:320189 11/25 (44%)
TM helix 3 189..219 CDD:320189 18/29 (62%)
TM helix 4 232..255 CDD:320189 11/24 (46%)
TM helix 5 272..297 CDD:320189 11/24 (46%)
7tm_GPCRs <533..605 CDD:475119 25/72 (35%)
TM helix 6 539..561 CDD:320189 10/21 (48%)
TM helix 7 573..598 CDD:320189 9/24 (38%)
ADRA2BNP_000673.2 7tmA_alpha2B_AR 7..437 CDD:320444 149/512 (29%)
TM helix 1 14..40 CDD:320444 13/25 (52%)
TM helix 2 47..73 CDD:320444 11/25 (44%)
TM helix 3 85..115 CDD:320444 18/29 (62%)
TM helix 4 127..150 CDD:320444 11/23 (48%)
TM helix 5 169..198 CDD:320444 13/29 (45%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 204..229 9/55 (16%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 241..329 16/89 (18%)
TM helix 6 364..394 CDD:320444 12/29 (41%)
TM helix 7 405..430 CDD:320444 9/24 (38%)

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