Protein Alignment TyrR and ADRA1A

DIOPT Version :10

• Sequence 1: NP_650652.1
• Gene: TyrR / 42136
• FlyBaseID: FBgn0038542
• Length: 631
• Species: Drosophila melanogaster
• Sequence 2: NP_150646.3
• Gene: ADRA1A / 148
• HGNCID: 277
• Length: 475
• Species: Homo sapiens
• Alignment Length: 541
• Identity: 140/541 - (25%)
• Similarity: 208/541 - (38%)
• Gaps: 205/541 - (37%)

  Fly    73 NGTDAVALTEPGPTAPVTTFNYYNESAAAAEWAHFYDLVLSWQGIILIAVFATFIVVTVIGNTLV 137
            |.:|:...|:  |.|||      |.|.|                |:|..:....|:..|:||.||
Human     7 NASDSSNCTQ--PPAPV------NISKA----------------ILLGVILGGLILFGVLGNILV 47

  Fly   138 ILAILTTRRLRTITNCFVMSLAVADLLVGIFVMPPAVAVHLIGSWQLGWVLCDIWISLDVLLCTA 202
            ||::...|.|.::|:.::::|||||||:...|:|.:....::|.|..|.|.|:||.::|||.|||
Human    48 ILSVACHRHLHSVTHYYIVNLAVADLLLTSTVLPFSAIFEVLGYWAFGRVFCNIWAAVDVLCCTA 112

  Fly   203 SILSLCAISVDRYLAVTRPLTYSRKRRSKRLALIMILIVWLLALAITCPPMLGWYEPGRRDLREC 267
            ||:.||.||:|||:.|:.||.|......:| .|:.:|.||.|:|.|:..|:.||.:|...|...|
Human   113 SIMGLCIISIDRYIGVSYPLRYPTIVTQRR-GLMALLCVWALSLVISIGPLFGWRQPAPEDETIC 176

  Fly   268 RYNQNEGYVIFSAMGSFFIPMAVMIYVYARISCVIASRHDNMTDISVHNKKFKRYTAADVENELS 332
            :.|:..|||:|||:|||::|:|:::.:|.|: .|:|.|.             .|...:.::.:.|
Human   177 QINEEPGYVLFSALGSFYLPLAIILVMYCRV-YVVAKRE-------------SRGLKSGLKTDKS 227

  Fly   333 EQEQHSSVGQRQRQATSRTFSNQTIAKELQDMMLSDSDNCAAMGAGGAGGGGGGASSATGGTHCQ 397
            :.|          |.|.|....                        .|..||.|.:||...||
Human   228 DSE----------QVTLRIHRK------------------------NAPAGGSGMASAKTKTH-- 256

  Fly   398 SLLALPSGGVGGSMGCAKNGCYELTRPSSLKRASTASTTITTMTSGMGPGSSLLDAQWQSQPPGQ 462
                                                                             
Human   257 ----------------------------------------------------------------- 256

  Fly   463 TGQVQTHSLSQPPRTHSFRHSHGERDRERLRSHHHHPHYHHQAGVTTTSTSGNTSANTNSKSLSN 527
                                                                          .|.
Human   257 --------------------------------------------------------------FSV 259

  Fly   528 RITSLKKENKTTQTLSIVVGGFIACWLPFFINYLITPFLAEHQASQMLAKALTWLGWFNSAINPF 592
            |:....:|.|..:||.||||.|:.||||||:...|..|..:.:.|:.:.|.:.|||:.||.|||.
Human   260 RLLKFSREKKAAKTLGIVVGCFVLCWLPFFLVMPIGSFFPDFKPSETVFKIVFWLGYLNSCINPI 324

  Fly   593 IYAFYSVDFRAAF---WRLTC 610
            ||...|.:|:.||   .|:.|
Human   325 IYPCSSQEFKKAFQNVLRIQC 345

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TyrR	NP_650652.1	7tmA_tyramine_R-like	118..>304	CDD:320189	76/185 (41%)
		TM helix 1	118..144	CDD:320189	9/25 (36%)
		TM helix 2	151..177	CDD:320189	10/25 (40%)
		TM helix 3	189..219	CDD:320189	18/29 (62%)
		TM helix 4	232..255	CDD:320189	9/22 (41%)
		TM helix 5	272..297	CDD:320189	12/24 (50%)
		7tm_GPCRs	<533..605	CDD:475119	31/71 (44%)
		TM helix 6	539..561	CDD:320189	13/21 (62%)
		TM helix 7	573..598	CDD:320189	11/24 (46%)
ADRA1A	NP_150646.3	7tmA_alpha1A_AR	27..337	CDD:320448	126/487 (26%)
		TM helix 1	28..54	CDD:320448	9/25 (36%)
		TM helix 2	61..87	CDD:320448	10/25 (40%)
		TM helix 3	99..129	CDD:320448	18/29 (62%)
		TM helix 4	141..164	CDD:320448	9/23 (39%)
		TM helix 5	181..210	CDD:320448	13/29 (45%)
		TM helix 6	265..295	CDD:320448	15/29 (52%)
		TM helix 7	305..330	CDD:320448	11/24 (46%)
		Nuclear localization signal	334..349		4/12 (33%)