Protein Alignment TyrR and ADRA1A

DIOPT Version :9

• Sequence 1: NP_001287381.1
• Gene: TyrR / 42136
• FlyBaseID: FBgn0038542
• Length: 631
• Species: Drosophila melanogaster
• Sequence 2: NP_150646.3
• Gene: ADRA1A / 148
• HGNCID: 277
• Length: 475
• Species: Homo sapiens
• Alignment Length: 541
• Identity: 140/541 - (25%)
• Similarity: 208/541 - (38%)
• Gaps: 205/541 - (37%)

  Fly    73 NGTDAVALTEPGPTAPVTTFNYYNESAAAAEWAHFYDLVLSWQGIILIAVFATFIVVTVIGNTLV 137
            |.:|:...|:  |.|||      |.|.|                |:|..:....|:..|:||.||
Human     7 NASDSSNCTQ--PPAPV------NISKA----------------ILLGVILGGLILFGVLGNILV 47

  Fly   138 ILAILTTRRLRTITNCFVMSLAVADLLVGIFVMPPAVAVHLIGSWQLGWVLCDIWISLDVLLCTA 202
            ||::...|.|.::|:.::::|||||||:...|:|.:....::|.|..|.|.|:||.::|||.|||
Human    48 ILSVACHRHLHSVTHYYIVNLAVADLLLTSTVLPFSAIFEVLGYWAFGRVFCNIWAAVDVLCCTA 112

  Fly   203 SILSLCAISVDRYLAVTRPLTYSRKRRSKRLALIMILIVWLLALAITCPPMLGWYEPGRRDLREC 267
            ||:.||.||:|||:.|:.||.|......:| .|:.:|.||.|:|.|:..|:.||.:|...|...|
Human   113 SIMGLCIISIDRYIGVSYPLRYPTIVTQRR-GLMALLCVWALSLVISIGPLFGWRQPAPEDETIC 176

  Fly   268 RYNQNEGYVIFSAMGSFFIPMAVMIYVYARISCVIASRHDNMTDISVHNKKFKRYTAADVENELS 332
            :.|:..|||:|||:|||::|:|:::.:|.|: .|:|.|.             .|...:.::.:.|
Human   177 QINEEPGYVLFSALGSFYLPLAIILVMYCRV-YVVAKRE-------------SRGLKSGLKTDKS 227

  Fly   333 EQEQHSSVGQRQRQATSRTFSNQTIAKELQDMMLSDSDNCAAMGAGGAGGGGGGASSATGGTHCQ 397
            :.|          |.|.|....                        .|..||.|.:||...||
Human   228 DSE----------QVTLRIHRK------------------------NAPAGGSGMASAKTKTH-- 256

  Fly   398 SLLALPSGGVGGSMGCAKNGCYELTRPSSLKRASTASTTITTMTSGMGPGSSLLDAQWQSQPPGQ 462
                                                                             
Human   257 ----------------------------------------------------------------- 256

  Fly   463 TGQVQTHSLSQPPRTHSFRHSHGERDRERLRSHHHHPHYHHQAGVTTTSTSGNTSANTNSKSLSN 527
                                                                          .|.
Human   257 --------------------------------------------------------------FSV 259

  Fly   528 RITSLKKENKTTQTLSIVVGGFIACWLPFFINYLITPFLAEHQASQMLAKALTWLGWFNSAINPF 592
            |:....:|.|..:||.||||.|:.||||||:...|..|..:.:.|:.:.|.:.|||:.||.|||.
Human   260 RLLKFSREKKAAKTLGIVVGCFVLCWLPFFLVMPIGSFFPDFKPSETVFKIVFWLGYLNSCINPI 324

  Fly   593 IYAFYSVDFRAAF---WRLTC 610
            ||...|.:|:.||   .|:.|
Human   325 IYPCSSQEFKKAFQNVLRIQC 345

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TyrR	NP_001287381.1	7tm_4	127..>249	CDD:304433	53/121 (44%)
		7tm_1	133..>298	CDD:278431	71/164 (43%)
ADRA1A	NP_150646.3	7tm_4	37..341	CDD:304433	126/481 (26%)
		7tm_1	43..326	CDD:278431	118/460 (26%)
		Nuclear localization signal	334..349		4/12 (33%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24248
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	2.010