DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment TyrR and ADRA1D

DIOPT Version :9

Sequence 1:	NP_001287381.1	Gene:	TyrR / 42136	FlyBaseID:	FBgn0038542	Length:	631	Species:	Drosophila melanogaster
Sequence 2:	NP_000669.1	Gene:	ADRA1D / 146	HGNCID:	280	Length:	572	Species:	Homo sapiens

Alignment Length:	603	Identity:	170/603 - (28%)
Similarity:	241/603 - (39%)	Gaps:	208/603 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly    21 AASSSSLRGLGLGS--------GVGVGGLPENISIVYEDAGNGTGGGGVGGVGGGYPSGPNGTDA 77
            :::..|..|.|.||        |..|||:|          |...|||||.|.|.|   ..|.:.|
Human    18 SSAGGSSAGGGGGSAGGAAPSEGPAVGGVP----------GGAGGGGGVVGAGSG---EDNRSSA 69

  Fly    78 VALTEPGPTAPVTTFNYYNESAAAAEWAHFYDLVLSWQGIILIAVFATFIVVTVIGNTLVILAIL 142
               .|||...   .....|.:||..      .||:|.||:.:....|.||::.|.||.||||::.
Human    70 ---GEPGSAG---AGGDVNGTAAVG------GLVVSAQGVGVGVFLAAFILMAVAGNLLVILSVA 122

  Fly   143 TTRRLRTITNCFVMSLAVADLLVGIFVMPPAVAVHLIGSWQLGWVLCDIWISLDVLLCTASILSL 207
            ..|.|:|:||.|:::|||||||:...|:|.:..:.::|.|..|...||:|.::|||.||||||||
Human   123 CNRHLQTVTNYFIVNLAVADLLLSATVLPFSATMEVLGFWAFGRAFCDVWAAVDVLCCTASILSL 187

  Fly   208 CAISVDRYLAVTRPLTYSRKRRSKRLALIMILIVWLLALAITCPPMLGWYEPGRRDLRECRYNQN 272
            |.||||||:.|...|.|......::.|.|:.|: |::||.::..|:|||.||...|.|.|...:.
Human   188 CTISVDRYVGVRHSLKYPAIMTERKAAAILALL-WVVALVVSVGPLLGWKEPVPPDERFCGITEE 251

  Fly   273 EGYVIFSAMGSFFIPMAVMIYVYARISCVIASRHDNMTDISVHNKKFKRYTAADVENELSEQEQH 337
            .||.:||::.||::||||::.:|.|:..|                  .|.|...:|..:
Human   252 AGYAVFSSVCSFYLPMAVIVVMYCRVYVV------------------ARSTTRSLEAGV------ 292

  Fly   338 SSVGQRQRQATSRTFSNQTIAKELQDMMLSDSDNCAAMGAGGAGGGGGGASSATGGTHCQSLLAL 402
                :|:|...|             :::|......||.||.||.|
Human   293 ----KRERGKAS-------------EVVLRIHCRGAATGADGAHG-------------------- 320

  Fly   403 PSGGVGGSMGCAKNGCYELTRPSSLKRASTASTTITTMTSGMGPGSSLLDAQWQSQPPGQTGQVQ 467
                                                 |.|..|
Human   321 -------------------------------------MRSAKG---------------------- 326

  Fly   468 THSLSQPPRTHSFRHSHGERDRERLRSHHHHPHYHHQAGVTTTSTSGNTSANTNSKSLSNRITSL 532
                      |:||                                         .|||.|:...
Human   327 ----------HTFR-----------------------------------------SSLSVRLLKF 340

  Fly   533 KKENKTTQTLSIVVGGFIACWLPFFINYLITPFLAEHQASQMLAKALTWLGWFNSAINPFIYAFY 597
            .:|.|..:||:||||.|:.||.|||....:.....:.:.|:.:.|.:.|||:|||.:||.||...
Human   341 SREKKAAKTLAIVVGVFVLCWFPFFFVLPLGSLFPQLKPSEGVFKVIFWLGYFNSCVNPLIYPCS 405

  Fly   598 SVDFRAAFWRL---TCKR 612
            |.:|:.||.||   .|:|
Human   406 SREFKRAFLRLLRCQCRR 423

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
TyrR	NP_001287381.1	7tm_4	127..>249	CDD:304433	56/121 (46%)
TyrR	NP_001287381.1	7tm_1	133..>298	CDD:278431	74/164 (45%)
ADRA1D	NP_000669.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..77		24/77 (31%)
		7tmA_alpha1D_AR	97..413	CDD:320450	132/487 (27%)
		TM helix 1	98..124	CDD:320450	10/25 (40%)
		TM helix 2	131..157	CDD:320450	12/25 (48%)
		TM helix 3	169..199	CDD:320450	21/29 (72%)
		TM helix 4	211..234	CDD:320450	7/23 (30%)
		TM helix 5	251..280	CDD:320450	12/28 (43%)
		TM helix 6	341..371	CDD:320450	14/29 (48%)
		TM helix 7	381..406	CDD:320450	11/24 (46%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	444..488
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	263	1.000	Inparanoid score	I3089
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.960