DRSC/TRiP Functional Genomics Resources

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Protein Alignment TyrR and ADORA2A

DIOPT Version :10

Sequence 1:NP_650652.1 Gene:TyrR / 42136 FlyBaseID:FBgn0038542 Length:631 Species:Drosophila melanogaster
Sequence 2:NP_000666.2 Gene:ADORA2A / 135 HGNCID:263 Length:412 Species:Homo sapiens


Alignment Length:517 Identity:108/517 - (20%)
Similarity:164/517 - (31%) Gaps:248/517 - (47%)


- Green bases have known domain annotations that are detailed below.


  Fly   118 ILIAVFATFIVVTVIGNTLVILAILTTRRLRTITNCFVMSLAVADLLVGIFVMPPAVAVHLIGSW 182
            :.|.|.....|:.::||.||..|:.....|:.:||.||:|||.||:.||:..:|.|:.:      
Human     8 VYITVELAIAVLAILGNVLVCWAVWLNSNLQNVTNYFVVSLAAADIAVGVLAIPFAITI------ 66

  Fly   183 QLGW-VLCD--IWISLDVLLCT-ASILSLCAISVDRYLAVTRPLTYSRKRRSKRLALIMILIVWL 243
            ..|: ..|.  ::|:..||:.| :||.||.||::|||:|:..||.|:......| |..:|.|.|:
Human    67 STGFCAACHGCLFIACFVLVLTQSSIFSLLAIAIDRYIAIRIPLRYNGLVTGTR-AKGIIAICWV 130

  Fly   244 LALAITCPPMLGWY-----EPGRRDLRECRYNQNEG--------------YVIFSAMGSFFIPMA 289
            |:.||...|||||.     :.|:...:.|    .||              .|.|:......:|:.
Human   131 LSFAIGLTPMLGWNNCGQPKEGKNHSQGC----GEGQVACLFEDVVPMNYMVYFNFFACVLVPLL 191

  Fly   290 VMIYVYARISCVIASRHDNMTDISVHNKKFKRYTAADVENELSEQEQHSSVGQRQRQATSRTFSN 354
            :|:.||.||  .:|:|                                                 
Human   192 LMLGVYLRI--FLAAR------------------------------------------------- 205

  Fly   355 QTIAKELQDMMLSDSDNCAAMGAGGAGGGGGGASSATGGTHCQSLLALPSGGVGGSMGCAKNGCY 419
                ::|:.|                                                       
Human   206 ----RQLKQM------------------------------------------------------- 211

  Fly   420 ELTRPSSLKRASTASTTITTMTSGMGPGSSLLDAQWQSQP-PGQTGQVQTHSLSQPPRTHSFRHS 483
                                                :||| ||                      
Human   212 ------------------------------------ESQPLPG---------------------- 218

  Fly   484 HGERDRERLRSHHHHPHYHHQAGVTTTSTSGNTSANTNSKSLSNRITSLKKENKTTQTLSIVVGG 548
                  ||.||                                    :|:||....::|:|:||.
Human   219 ------ERARS------------------------------------TLQKEVHAAKSLAIIVGL 241

  Fly   549 FIACWLPFFINYLITPFLAE--HQASQMLAKALTWLGWFNSAINPFIYAFYSVDFRAAFWRL 608
            |..||||..|....|.|..:  |....::..|:. |...||.:||||||:...:||..|.::
Human   242 FALCWLPLHIINCFTFFCPDCSHAPLWLMYLAIV-LSHTNSVVNPFIYAYRIREFRQTFRKI 302

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
TyrRNP_650652.1 7tmA_tyramine_R-like 118..>304 CDD:320189 66/208 (32%)
TM helix 1 118..144 CDD:320189 8/25 (32%)
TM helix 2 151..177 CDD:320189 13/25 (52%)
TM helix 3 189..219 CDD:320189 15/32 (47%)
TM helix 4 232..255 CDD:320189 10/22 (45%)
TM helix 5 272..297 CDD:320189 8/38 (21%)
7tm_GPCRs <533..605 CDD:475119 27/73 (37%)
TM helix 6 539..561 CDD:320189 10/21 (48%)
TM helix 7 573..598 CDD:320189 10/24 (42%)
ADORA2ANP_000666.2 7tmA_Adenosine_R_A2A 7..299 CDD:320196 107/512 (21%)
TM helix 1 8..34 CDD:320196 8/25 (32%)
TM helix 2 41..68 CDD:320196 13/32 (41%)
TM helix 3 77..107 CDD:320196 14/29 (48%)
TM helix 4 121..139 CDD:320196 7/17 (41%)
TM helix 5 174..204 CDD:320196 8/31 (26%)
TM helix 6 226..256 CDD:320196 12/29 (41%)
TM helix 7 267..292 CDD:320196 10/25 (40%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 391..412
Blue background indicates that the domain is not in the aligned region.

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