Protein Alignment TyrR and Drd1

DIOPT Version :10

• Sequence 1: NP_650652.1
• Gene: TyrR / 42136
• FlyBaseID: FBgn0038542
• Length: 631
• Species: Drosophila melanogaster
• Sequence 2: NP_034206.1
• Gene: Drd1 / 13488
• MGIID: 99578
• Length: 446
• Species: Mus musculus
• Alignment Length: 519
• Identity: 130/519 - (25%)
• Similarity: 189/519 - (36%)
• Gaps: 216/519 - (41%)

  Fly   118 ILIAVFATFIVV-TVIGNTLVILAILTTRRLRT-ITNCFVMSLAVADLLVGIFVMPPAVAVHLIG 180
            ||.|.|.:.::: |::|||||..|::..|.||: :||.||:||||:||||.:.|||......:.|
Mouse    23 ILTACFLSLLILSTLLGNTLVCAAVIRFRHLRSKVTNFFVISLAVSDLLVAVLVMPWKAVAEIAG 87

  Fly   181 SWQLGWVLCDIWISLDVLLCTASILSLCAISVDRYLAVTRPLTYSRKRRSKRLALIMILIVWLLA 245
            .|..| ..|:||::.|::..|||||:||.||||||.|::.|..|.||...| .|.|:|.:.|.|:
Mouse    88 FWPFG-SFCNIWVAFDIMCSTASILNLCVISVDRYWAISSPFQYERKMTPK-AAFILISVAWTLS 150

  Fly   246 LAIT-CPPMLGWY---------------EPGRRDLRECRYNQNEGYVIFSAMGSFFIPMAVMIYV 294
            :.|: .|..|.|:               |....|  .|....:..|.|.|::.||:||:|:||..
Mouse   151 VLISFIPVQLSWHKAKPTWPLDGNFTSLEDAEDD--NCDTRLSRTYAISSSLISFYIPVAIMIVT 213

  Fly   295 YARISCVIASRHDNMTDISVHNKKFKRYTAADVENELSEQEQHSSVGQRQRQATSRTFSNQTIAK 359
            |..|                                       ..:.|:|
Mouse   214 YTSI---------------------------------------YRIAQKQ--------------- 224

  Fly   360 ELQDMMLSDSDNCAAMGAGGAGGGGGGASSATGGTHCQSLLALPSGGVGGSMGCAKNGCYELTRP 424
                                                                         :.|.
Mouse   225 -------------------------------------------------------------IRRI 228

  Fly   425 SSLKRASTASTTITTMTSGMGPGSSLLDAQWQSQPPGQTGQVQTHSLSQPPRTHSFRHSHGERDR 489
            |:|:||:.
Mouse   229 SALERAAV--------------------------------------------------------- 236

  Fly   490 ERLRSHHHHPHYHHQAGVTTTSTSGNTSANTNSKSLSNRITSLKKENKTTQTLSIVVGGFIACWL 554
                         |.....||:.:||....:.|:|...  .|.|:|.|..:|||:::|.|:.|||
Mouse   237 -------------HAKNCQTTTGNGNPVECSQSESSFK--MSFKRETKVLKTLSVIMGVFVCCWL 286

  Fly   555 PFFINYLITPFLAEHQASQMLAKALT-----WLGWFNSAINPFIYAFYSVDFRAAFWRLT-CKR 612
            ||||:..:.||....:.......::|     |.||.||::||.|||| :.||:.||..|. |.|
Mouse   287 PFFISNCMVPFCGSEETQPFCIDSITFDVFVWFGWANSSLNPIIYAF-NADFQKAFSTLLGCYR 349

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TyrR	NP_650652.1	7tmA_tyramine_R-like	118..>304	CDD:320189	79/203 (39%)
		TM helix 1	118..144	CDD:320189	11/26 (42%)
		TM helix 2	151..177	CDD:320189	15/25 (60%)
		TM helix 3	189..219	CDD:320189	18/29 (62%)
		TM helix 4	232..255	CDD:320189	7/23 (30%)
		TM helix 5	272..297	CDD:320189	11/24 (46%)
		7tm_GPCRs	<533..605	CDD:475119	31/76 (41%)
		TM helix 6	539..561	CDD:320189	12/21 (57%)
		TM helix 7	573..598	CDD:320189	12/29 (41%)
Drd1	NP_034206.1	7tm_GPCRs	22..341	CDD:475119	125/509 (25%)
		TM helix 1	25..49	CDD:410628	9/23 (39%)
		TM helix 2	59..81	CDD:410628	14/21 (67%)
		TM helix 3	96..118	CDD:410628	11/21 (52%)
		TM helix 4	141..157	CDD:410628	5/15 (33%)
		TM helix 5	192..215	CDD:410628	10/22 (45%)
		TM helix 6	271..293	CDD:410628	12/21 (57%)
		TM helix 7	310..335	CDD:410628	12/25 (48%)