Protein Alignment TyrR and TAAR1

DIOPT Version :10

• Sequence 1: NP_650652.1
• Gene: TyrR / 42136
• FlyBaseID: FBgn0038542
• Length: 631
• Species: Drosophila melanogaster
• Sequence 2: NP_612200.1
• Gene: TAAR1 / 134864
• HGNCID: 17734
• Length: 339
• Species: Homo sapiens
• Alignment Length: 535
• Identity: 117/535 - (21%)
• Similarity: 172/535 - (32%)
• Gaps: 230/535 - (42%)

  Fly    93 NYYNESAAAAEWAHFYDLVLSWQGIILIAVFATFIVVTVIGNTLVILAILTTRRLRTITNCFVMS 157
            |..|.|.....|::  |:..|     |.::....|:.|::||.:||::|...::|.|.||..:.|
Human     7 NIINISCVKNNWSN--DVRAS-----LYSLMVLIILTTLVGNLIVIVSISHFKQLHTPTNWLIHS 64

  Fly   158 LAVADLLVGIFVMPPAVAVHLIGSWQLGWVLCDIWISLDVLLCTASILSLCAISVDRYLAVTRPL 222
            :|..|.|:|..|||.::.......|..|.|.|.|..|.|::|.:|||..|..||:|||.||..||
Human    65 MATVDFLLGCLVMPYSMVRSAEHCWYFGEVFCKIHTSTDIMLSSASIFHLSFISIDRYYAVCDPL 129

  Fly   223 TYSRKRRSKRLALIMILIVWLLALAITCPPMLGWYEPGRRDLRE-------CR------YNQNEG 274
            .|..| .:..:..:||.|.|.:. |:....|: :.|...:...|       ||      :::..|
Human   130 RYKAK-MNILVICVMIFISWSVP-AVFAFGMI-FLELNFKGAEEIYYKHVHCRGGCSVFFSKISG 191

  Fly   275 YVIFSAMGSFFIPMAVMIYVYARISCVIASRHDNMTDISVHNKKFKRYTAADVENELSEQEQHSS 339
            .:.|  |.||:||.::|:.||.||
Human   192 VLTF--MTSFYIPGSIMLCVYYRI----------------------------------------- 213

  Fly   340 VGQRQRQATSRTFSNQTIAKELQDMMLSDSDNCAAMGAGGAGGGGGGASSATGGTHCQSLLALPS 404
                           ..|||| |..::||::                          |.|
Human   214 ---------------YLIAKE-QARLISDAN--------------------------QKL----- 231

  Fly   405 GGVGGSMGCAKNGCYELTRPSSLKRASTASTTITTMTSGMGPGSSLLDAQWQSQPPGQTGQVQTH 469
                                                                     |.|....:
Human   232 ---------------------------------------------------------QIGLEMKN 239

  Fly   470 SLSQPPRTHSFRHSHGERDRERLRSHHHHPHYHHQAGVTTTSTSGNTSANTNSKSLSNRITSLKK 534
            .:||                                                           .|
Human   240 GISQ-----------------------------------------------------------SK 245

  Fly   535 ENKTTQTLSIVVGGFIACWLPFFINYLITPFLAEHQASQMLAKALTWLGWFNSAINPFIYAFYSV 599
            |.|..:||.||:|.|:.||.||||..::.||| .:.....|...|.|.|:.||..||.:|||:..
Human   246 ERKAVKTLGIVMGVFLICWCPFFICTVMDPFL-HYIIPPTLNDVLIWFGYLNSTFNPMVYAFFYP 309

  Fly   600 DFRAAFWRLTCKRFF 614
            .||.|...:...:.|
Human   310 WFRKALKMMLFGKIF 324

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TyrR	NP_650652.1	7tmA_tyramine_R-like	118..>304	CDD:320189	65/198 (33%)
		TM helix 1	118..144	CDD:320189	8/25 (32%)
		TM helix 2	151..177	CDD:320189	10/25 (40%)
		TM helix 3	189..219	CDD:320189	15/29 (52%)
		TM helix 4	232..255	CDD:320189	6/22 (27%)
		TM helix 5	272..297	CDD:320189	10/24 (42%)
		7tm_GPCRs	<533..605	CDD:475119	31/71 (44%)
		TM helix 6	539..561	CDD:320189	12/21 (57%)
		TM helix 7	573..598	CDD:320189	11/24 (46%)
TAAR1	NP_612200.1	7tmA_TAAR1	26..315	CDD:320438	109/498 (22%)
		TM helix 1	26..51	CDD:320438	8/24 (33%)
		TM helix 2	58..84	CDD:320438	10/25 (40%)
		TM helix 3	96..126	CDD:320438	15/29 (52%)
		TM helix 4	138..161	CDD:320438	6/24 (25%)
		Extracellular Loop 2 (ECL2). /evidence=ECO:0000269|PubMed:37935376, ECO:0000269|PubMed:37935377, ECO:0000269|PubMed:37963465	175..186		2/10 (20%)
		TM helix 5	187..216	CDD:320438	12/86 (14%)
		TM helix 6	244..274	CDD:320438	15/29 (52%)
		TM helix 7	283..308	CDD:320438	11/24 (46%)