Protein Alignment TyrR and TAAR9

DIOPT Version :10

• Sequence 1: NP_650652.1
• Gene: TyrR / 42136
• FlyBaseID: FBgn0038542
• Length: 631
• Species: Drosophila melanogaster
• Sequence 2: NP_778227.3
• Gene: TAAR9 / 134860
• HGNCID: 20977
• Length: 348
• Species: Homo sapiens
• Alignment Length: 509
• Identity: 101/509 - (19%)
• Similarity: 156/509 - (30%)
• Gaps: 257/509 - (50%)

  Fly   118 ILIAVFATFIVVTVIGNTLVILAILTTRRLRTITNCFVMSLAVADLLVGIFVMPPAVAVHLIGSW 182
            ||.||.....|:...||.||::|||..::|.|.||..:.|||.||.|||:.|||.:....:...|
Human    34 ILYAVLGFGAVLAAFGNLLVMIAILHFKQLHTPTNFLIASLACADFLVGVTVMPFSTVRSVESCW 98

  Fly   183 QLGWVLCDIWISLDVLLCTASILSLCAISVDRYLAVTRPLTYSRKRRSKRLALIMILIVWL---- 243
            ..|...|......|...|.||:..||.||||||:|||.||||..| .:..::.|.|::.|.
Human    99 YFGDSYCKFHTCFDTSFCFASLFHLCCISVDRYIAVTDPLTYPTK-FTVSVSGICIVLSWFFSVT 162

  Fly   244 -----------------LALAITCPPMLGWYEPGRRDLRECRYNQNEGYVIFSAMGSFFIPMAVM 291
                             |.:|:||             :..|:...|:.:|:...: .||||...|
Human   163 YSFSIFYTGANEEGIEELVVALTC-------------VGGCQAPLNQNWVLLCFL-LFFIPNVAM 213

  Fly   292 IYVYARISCVIASRHDNMTDISVHNKKFKRYTAADVENELSEQEQHSSVGQRQRQATSRTFSNQT 356
            :::|::|  .:.::|.
Human   214 VFIYSKI--FLVAKHQ------------------------------------------------- 227

  Fly   357 IAKELQDMMLSDSDNCAAMGAGGAGGGGGGASSATGGTHCQSLLALPSGGVGGSMGCAKNGCYEL 421
             |::::
Human   228 -ARKIE----------------------------------------------------------- 232

  Fly   422 TRPSSLKRASTASTTITTMTSGMGPGSSLLDAQWQSQPPGQTGQVQTHSLSQPPRTHSFRHSHGE 486
                     ||||
Human   233 ---------STAS---------------------------------------------------- 236

  Fly   487 RDRERLRSHHHHPHYHHQAGVTTTSTSGNTSANTNSKSLSNRITSLKKENKTTQTLSIVVGGFIA 551
                                          .|.::|:|...|:.  |:|.|..:||.|.:..|:.
Human   237 ------------------------------QAQSSSESYKERVA--KRERKAAKTLGIAMAAFLV 269

  Fly   552 CWLPF--------FINYLITPFLAEHQASQMLAKALTWLGWFNSAINPFIYAFY 597
            .|||:        ::|::..|::.|         .|.|..::|||:||.||||:
Human   270 SWLPYLVDAVIDAYMNFITPPYVYE---------ILVWCVYYNSAMNPLIYAFF 314

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TyrR	NP_650652.1	7tmA_tyramine_R-like	118..>304	CDD:320189	67/206 (33%)
		TM helix 1	118..144	CDD:320189	12/25 (48%)
		TM helix 2	151..177	CDD:320189	13/25 (52%)
		TM helix 3	189..219	CDD:320189	14/29 (48%)
		TM helix 4	232..255	CDD:320189	7/43 (16%)
		TM helix 5	272..297	CDD:320189	8/24 (33%)
		7tm_GPCRs	<533..605	CDD:475119	24/73 (33%)
		TM helix 6	539..561	CDD:320189	8/29 (28%)
		TM helix 7	573..598	CDD:320189	11/25 (44%)
TAAR9	NP_778227.3	7tmA_TAAR6_8_9	33..322	CDD:320439	101/509 (20%)
		TM helix 1	34..60	CDD:320439	12/25 (48%)
		TM helix 2	67..93	CDD:320439	13/25 (52%)
		TM helix 3	105..135	CDD:320439	14/29 (48%)
		TM helix 4	147..170	CDD:320439	3/22 (14%)
		Extracellular Loop 2 (ECL2). /evidence=ECO:0000250|UniProtKB:Q5QD04	174..187		4/25 (16%)
		TM helix 5	194..223	CDD:320439	9/31 (29%)
		TM helix 6	251..281	CDD:320439	10/29 (34%)
		TM helix 7	290..315	CDD:320439	13/34 (38%)