Protein Alignment TyrR and Dop1R1

DIOPT Version :10

• Sequence 1: NP_650652.1
• Gene: TyrR / 42136
• FlyBaseID: FBgn0038542
• Length: 631
• Species: Drosophila melanogaster
• Sequence 2: XP_061506303.1
• Gene: Dop1R1 / 1275919
• VectorBaseID: AGAMI1_010805
• Length: 445
• Species: Anopheles gambiae
• Alignment Length: 622
• Identity: 146/622 - (23%)
• Similarity: 222/622 - (35%)
• Gaps: 242/622 - (38%)

  Fly    16 SLMYVAASSSSLRGLGLGSGVGVGGLPENISIVYEDAGNGTG-GGGVGGVGG-GYPSGP---NGT 75
            :|.|::::|:.:....:|          |::.|.:..|:|.| |.|.|...| |.|.||   ...
Mosquito    10 TLGYLSSTSTVVSATTIG----------NLTSVNQTDGSGDGSGSGTGASSGTGIPGGPGEDTDD 64

  Fly    76 DAVALTEPGPTAPVTTFNYYNESAAAAEWAHFYDLVLSWQGIILIAVFATFIVVTVIGNTLVILA 140
            |.|.:..|                          |.:|:.|:.|..|    |.::|.||.||.:|
Mosquito    65 DDVDVLSP--------------------------LSMSFLGVFLSIV----IFLSVAGNILVCIA 99

  Fly   141 ILTTRRLRTITNCFVMSLAVADLLVGIFVMPPAVAVHLIGSWQLGWVLCDIWISLDVLLCTASIL 205
            |.|.|.||.|.|.|:.|||:|||.|...||..|....|:|.|..|...||.|::.||:..|||||
Mosquito   100 IYTERSLRRIGNLFLASLAIADLFVASLVMTFAGVNDLLGYWIFGAQFCDTWVAFDVMCSTASIL 164

  Fly   206 SLCAISVDRYLAVTRPLTYSRKRRSKRLALIMILIVWLLALAITCPPMLGWYEPGRRDLRE---- 266
            :|||||:|||:.:..||.|.| ..::|:|:..|.::||||..::..|:.......:||..:
Mosquito   165 NLCAISLDRYIHIKDPLRYGR-WVTRRVAIGTIAVIWLLAALVSFVPISLDLHRDKRDKTDTSLK 228

  Fly   267 --------CRYNQNEGYVIFSAMGSFFIPMAVMIYVYARISCVIASRHDNMTDISVHNKKFKRYT 323
                    |..:....|.:.|:..||::|..|||.:|.|:.|....
Mosquito   229 INGIKYETCALDLTPTYAVVSSCISFYVPCIVMIGIYCRLYCYAQK------------------- 274

  Fly   324 AADVENELSEQEQHSSVGQRQRQATSRTFSNQTIAKELQDMMLSDSDNCAAMGAGGAGGGGGGAS 388
                                                                             
Mosquito   275 ----------------------------------------------------------------- 274

  Fly   389 SATGGTHCQSLLALPSGGVGGSMGCAKNGCYELTRPSSLKRASTASTTITTMTSGMGPGSSLLDA 453
                  |.:|:.|                   :|||..:..
Mosquito   275 ------HVKSIRA-------------------VTRPGEISE------------------------ 290

  Fly   454 QWQSQPPGQTGQVQTHSLSQPPRTHSFRHSHGERDRERLRSHHHHPHYHHQAGVTTTSTSGNTSA 518
                                 .|..|.|.....:::.:||...|           |.|:..:.|
Mosquito   291 ---------------------KRYRSIRRPKSSKNKLKLRQLAH-----------TASSPYHVS- 322

  Fly   519 NTNSKSLSNRITSLKKENKTTQTLSIVVGGFIACWLPFFINYLITPFLAEHQASQMLAKALTWLG 583
                            ::|...|:.:::|.|:.||:|||...:|..| .:....|...|.|:|||
Mosquito   323 ----------------DHKAAITVGVIMGVFLICWVPFFCVNIIAAF-CKTCIGQQTFKVLSWLG 370

  Fly   584 WFNSAINPFIYAFYSVDFRAAFWR-LTCKRFFSAGQK 619
            :.|||.||.||:.::.:||.||.| ||.:..:..||:
Mosquito   371 YSNSAFNPIIYSIFNTEFREAFKRILTSRSSWCCGQE 407

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TyrR	NP_650652.1	7tmA_tyramine_R-like	118..>304	CDD:320189	75/197 (38%)
		TM helix 1	118..144	CDD:320189	10/25 (40%)
		TM helix 2	151..177	CDD:320189	12/25 (48%)
		TM helix 3	189..219	CDD:320189	18/29 (62%)
		TM helix 4	232..255	CDD:320189	8/22 (36%)
		TM helix 5	272..297	CDD:320189	9/24 (38%)
		7tm_GPCRs	<533..605	CDD:475119	26/71 (37%)
		TM helix 6	539..561	CDD:320189	8/21 (38%)
		TM helix 7	573..598	CDD:320189	13/24 (54%)
Dop1R1	XP_061506303.1	None