Protein Alignment TyrR and Dop2R

DIOPT Version :10

• Sequence 1: NP_650652.1
• Gene: TyrR / 42136
• FlyBaseID: FBgn0038542
• Length: 631
• Species: Drosophila melanogaster
• Sequence 2: XP_061499915.1
• Gene: Dop2R / 1274598
• VectorBaseID: AGAMI1_010373
• Length: 659
• Species: Anopheles gambiae
• Alignment Length: 618
• Identity: 174/618 - (28%)
• Similarity: 283/618 - (45%)
• Gaps: 119/618 - (19%)

  Fly    41 LPENISIVYEDAGNGTGGGGVGGVGGGYPSGPNGTDAVAL-------TEPGPTAPVTTFNYYNES 98
            |.|:|..::.:| |||.|              |.|..:|:       |..|||
Mosquito   107 LAEDIGSIFYNA-NGTFG--------------NDTTGLAVNCSLSNTTCIGPT------------ 144

  Fly    99 AAAAEWAHFYDLVLSWQGIILIAVFATFIVVTVIGNTLVILAILTTRRLRTITNCFVMSLAVADL 163
             .|.|: |::.|:|           ..|.::|:.||.|||||:...|.|:|:||.|::|||:|||
Mosquito   145 -EAKEY-HYWCLIL-----------VLFPILTLFGNVLVILAVCRERTLQTVTNYFIVSLAIADL 196

  Fly   164 LVGIFVMPPAVAVHLIGSWQLGWVLCDIWISLDVLLCTASILSLCAISVDRYLAVTRPLTYSRKR 228
            ||.:.|||.||.|.:.|:|.|....||.:|::||:..|:||.:|.|||:|||:|||:|:.|::.:
Mosquito   197 LVAVVVMPFAVYVLVNGAWTLPNFACDFYIAMDVICSTSSIFNLVAISIDRYIAVTQPIKYAKHK 261

  Fly   229 RSKRLALIMILIVWLLALAITCPPMLGWYEPGRRDLRECRYNQNEGYVIFSAMGSFFIPMAVMIY 293
            .|:|:.| .||:||.::.||..|.:||......|....|.: .|..::::|::.||:||..:|::
Mosquito   262 NSRRVCL-TILLVWAISAAIGSPIVLGLNNTQDRSPDLCVF-YNTDFIVYSSLTSFYIPCIIMVF 324

  Fly   294 VYARISCVI--------ASRHDNMTDIS-----VHN-KKFKRYTAADVENELSEQEQHSSVGQRQ 344
            :|..|...:        |:|..::::|:     :.| .:.||  .|:.:.:.|.:.....:...:
Mosquito   325 LYWNIFKALRTRAKKQRAARKPHLSEITAGGSIIENIAQTKR--LAETQLDGSTRSGSKILPDEE 387

  Fly   345 RQATSRTFSNQTIAKELQDMMLSDSDNC------------AAMGAGGAGGGGGGASSATGGTHCQ 397
            |...:.:.||:   ::.::....|.|:|            .|.....||......|:.:......
Mosquito   388 RPTNTASGSNE---EDDENAGSPDIDDCHVIVNDKSTEFMLATVVEEAGNKSFSTSTFSVVAQIA 449

  Fly   398 SLLALPSGGVGG-SMGCAKNG-----CYELTRPSSLKRASTA----STTITTMTSGMGPGSSLLD 452
            :...:||...|. ..|.|.:.     ....|.|.||...:|.    |.||.:..     ||...:
Mosquito   450 TTQQVPSDPNGNHDSGYAPSSIADALAVNATPPESLNVTATVIVNKSATIRSRN-----GSPRKE 509

  Fly   453 AQWQSQPPG--QTGQVQTHSLSQPPRTHSFRHSHGERDRERLRSHHHHPHYHHQAGVTTTSTSGN 515
            |....:|..  :.|..|..:|::...|.|.......|..::                 .|..|..
Mosquito   510 ASVTLKPLSLVRCGVQQALTLNRNDSTLSTNSRDSSRKDKK-----------------NTQASRF 557

  Fly   516 TSANTNSKSLSNR-ITSLKKENKTTQTLSIVVGGFIACWLPFFINYLITPFLA----EHQASQML 575
            |....|..|...| .:|.|||.|.|:||:||:|.|:.||:|||...::....|    :.:....:
Mosquito   558 TIYKVNKASKKKREKSSAKKERKATKTLAIVLGVFLFCWVPFFTCNIMDAMCAKLDKDCRPGVTI 622

  Fly   576 AKALTWLGWFNSAINPFIYAFYSVDFRAAFWRL 608
            ....||||:.||.:||.||..::.:||.||.::
Mosquito   623 FNLTTWLGYMNSFVNPVIYTIFNPEFRKAFKKI 655

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TyrR	NP_650652.1	7tmA_tyramine_R-like	118..>304	CDD:320189	75/193 (39%)
		TM helix 1	118..144	CDD:320189	9/25 (36%)
		TM helix 2	151..177	CDD:320189	16/25 (64%)
		TM helix 3	189..219	CDD:320189	16/29 (55%)
		TM helix 4	232..255	CDD:320189	9/22 (41%)
		TM helix 5	272..297	CDD:320189	8/24 (33%)
		7tm_GPCRs	<533..605	CDD:475119	29/75 (39%)
		TM helix 6	539..561	CDD:320189	12/21 (57%)
		TM helix 7	573..598	CDD:320189	10/24 (42%)
Dop2R	XP_061499915.1	None