Protein Alignment TyrR and AdoR

DIOPT Version :10

• Sequence 1: NP_650652.1
• Gene: TyrR / 42136
• FlyBaseID: FBgn0038542
• Length: 631
• Species: Drosophila melanogaster
• Sequence 2: XP_310647.2
• Gene: AdoR / 1271793
• VectorBaseID: AGAMI1_006181
• Length: 392
• Species: Anopheles gambiae
• Alignment Length: 586
• Identity: 139/586 - (23%)
• Similarity: 199/586 - (33%)
• Gaps: 239/586 - (40%)

  Fly    54 NGTGGGGVGGVGGGYPSGPNGTDAVALTEPGPTAPVTTFNYYNESAAAAEWAHFYDLVLSWQGII 118
            |||.|.|            |||.    .|| |.|||.    .|...|..|
Mosquito    19 NGTPGWG------------NGTG----DEP-PEAPVR----LNLPYALLE--------------- 47

  Fly   119 LIAVFATFIVVTVIGNTLVILAILTTRRLRTITNCFVMSLAVADLLVGIFVMPPAVA-------- 175
                 ||..::.:.||||||:|..|.||||..||.:::|||.||||||...:|.||.
Mosquito    48 -----ATVALMAIFGNTLVIVAFRTERRLRRRTNYYIVSLASADLLVGTLGIPFAVLASIGLPRN 107

  Fly   176 VHLIGSWQLGWVLCDIWISLDVLLCTASILSLCAISVDRYLAVTRPLTYSRKRRSKRLALIMILI 240
            :|          .|...|||.|:|||.||..|.|:|:|||.|:..||.|||..|:| ..|.:|.:
Mosquito   108 LH----------ACLFTISLLVVLCTISIFCLVAVSIDRYWAILHPLAYSRNMRTK-TTLYIISM 161

  Fly   241 VWLLALAITCPPMLGWYEPGRRDLRECRYNQ--NEGYVIFSAMGSFFIPMAVMIYVYARISCVIA 303
            .||....:...|:.||:|....|  .|.:.:  |..|::|..:.:..||..:::..|..|..||.
Mosquito   162 CWLAGFIVGFLPLFGWHEQPAED--ACLFVKVMNYDYLVFLYLVTIIIPAVLLLAFYIHIYRVIV 224

  Fly   304 SRHDNMTDISVHNKKFKRYTAADVENELSEQEQHSSVGQRQRQATSRTFSNQTIAKELQDMMLSD 368
                                                   |||             |::..:...|
Mosquito   225 ---------------------------------------RQR-------------KQILSVNSID 237

  Fly   369 SDNCAAMGAGGAGGGGGGASSATGGTHCQSLLALPSGGVGGSMGCAKNGCYELTRPSSLKRASTA 433
            | .|.|....|.|                              .|:::|.: .|:..:.::...:
Mosquito   238 S-RCMASIEDGTG------------------------------SCSQSGRH-ATKRRTQRKDQYS 270

  Fly   434 STTITTMTSGMGPGSSLLDAQWQSQPPGQTGQVQTHSLSQPPRTHSFRHSHGERDRERLRSHHHH 498
            .|.:..:
Mosquito   271 GTMLRVL---------------------------------------------------------- 277

  Fly   499 PHYHHQAGVTTTSTSGNTSANTNSKSLSNRITSLKKENKTTQTLSIVVGGFIACWLPFFINYLIT 563
                                    ::..||      |.|.||.|||:|..|:.||:|......|.
Mosquito   278 ------------------------RAAQNR------EVKATQNLSIIVLFFMLCWMPLHTINCIV 312

  Fly   564 PFLAE-HQASQMLAKALTWLGWFNSAINPFIYAFYSVDFRAAFWRLTCKRFFSAGQKPQFPTNTM 627
            .|..: |..:.::...:| |...|||:||.:||::..|||||..||... .|....:|..|.:.:
Mosquito   313 AFCPQCHIHAPVMLLVIT-LSHLNSALNPLLYAYHLKDFRAALKRLLLS-LFGIAPRPAPPRDCV 375

  Fly   628 S 628
            :
Mosquito   376 N 376

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TyrR	NP_650652.1	7tmA_tyramine_R-like	118..>304	CDD:320189	72/195 (37%)
		TM helix 1	118..144	CDD:320189	9/25 (36%)
		TM helix 2	151..177	CDD:320189	14/33 (42%)
		TM helix 3	189..219	CDD:320189	17/29 (59%)
		TM helix 4	232..255	CDD:320189	5/22 (23%)
		TM helix 5	272..297	CDD:320189	6/24 (25%)
		7tm_GPCRs	<533..605	CDD:475119	28/72 (39%)
		TM helix 6	539..561	CDD:320189	10/21 (48%)
		TM helix 7	573..598	CDD:320189	9/24 (38%)
AdoR	XP_310647.2	None