Protein Alignment TyrR and 5-HT2A

DIOPT Version :10

• Sequence 1: NP_650652.1
• Gene: TyrR / 42136
• FlyBaseID: FBgn0038542
• Length: 631
• Species: Drosophila melanogaster
• Sequence 2: XP_061500179.1
• Gene: 5-HT2A / 1269329
• VectorBaseID: AGAMI1_010455
• Length: 825
• Species: Anopheles gambiae
• Alignment Length: 611
• Identity: 165/611 - (27%)
• Similarity: 249/611 - (40%)
• Gaps: 158/611 - (25%)

  Fly    69 PSGPNGTD--AVA-------------LTEPGPTAPVTTFNYYNESAAAAEWAHFYDLVLSWQGII 118
            |:..||.:  |||             |...|.|||           ...||:..:        :|
Mosquito   274 PTWLNGAEHHAVAALAGWNQTQLLGELPAGGDTAP-----------GRYEWSFLF--------VI 319

  Fly   119 LIAVFATFIVVTVIGNTLVILAILTTRRLRTITNCFVMSLAVADLLVGIFVMPPAVAVHLIGSWQ 183
            |      ||....:||.||.||:...|:|:.:||.|::|||:|||||.:||||.......:|.|.
Mosquito   320 L------FIFAGGLGNILVCLAVALDRKLQNVTNYFLLSLAIADLLVSLFVMPLGAIPGFLGYWP 378

  Fly   184 LGWVLCDIWISLDVLLCTASILSLCAISVDRYLAVTRPLTYSRKRRSKRLALIMILIVWLLALAI 248
            .|...|:|:::.|||.|:||||.:|.||:.|||.:..||. ||...:|||..|.|.:|||||:.:
Mosquito   379 FGVTWCNIYVTCDVLACSASILHMCFISLGRYLGIRNPLG-SRHHSTKRLTGIKIALVWLLAMLV 442

  Fly   249 TCP-PMLGWYE-----PGRRDLRECRYNQNEGYVIFSAMGSFFIPMAVMIYVYARISCVIASRHD 307
            :.. .:||...     ||.   .||..| |..:.:|.::.:|:|||.:|:..||
Mosquito   443 SSSITVLGMINQNNIMPGP---NECVIN-NRAFFVFGSLVAFYIPMVMMVVTYA----------- 492

  Fly   308 NMTDISVHNKKFKRYTAADVENELSEQ-------EQHSSVGQRQRQATSRTFSNQTIAKELQDMM 365
              ..:.:..|| .|:.....|.||..:       .:||:..|....:||..      |.|::...
Mosquito   493 --LTVQLLRKK-ARFLEQHPEGELFRRLGGRLASSKHSNNSQSDGSSTSNK------AVEMRKFT 548

  Fly   366 LSDSDNCAAMGAGGAGGGGGGASSATGGTHCQSLLALPSGGVGGSMGCAKNGCYELTRPSSLKRA 430
            ::::...|                                          .|.::.:.||||
Mosquito   549 VNNNKQPA------------------------------------------YGQHDSSPPSSL--- 568

  Fly   431 STASTTITTMTSGMGPGSSLLDAQWQSQPPGQTGQVQTH------SLSQPPRTHS---FRHSHGE 486
                       ..:..|.|.|..:|.....| ||::.:.      |:|.|...:|   .|...|:
Mosquito   569 -----------PSVAAGHSALPWRWHGTTAG-TGKMDSRMSSIKGSMSHPHLGYSNGGNRTMAGK 621

  Fly   487 RDR-------------ERLRSHHHHPHYH-HQAGVTTTSTSGNTSANTNSKSLSNRITSLKKENK 537
            |.|             ||.........:. |...|.|.:.:.|.....:.|..:....::..|.|
Mosquito   622 RSRTVCDQGTQTPDSIERETRRQKFCSFRIHLNSVPTPAINFNLKFLGSKKRTNLSANAVATEQK 686

  Fly   538 TTQTLSIVVGGFIACWLPFFINYLITPFLAEHQASQMLAKALTWLGWFNSAINPFIYAFYSVDFR 602
            .|:.|.:|...|:.||.||||..:|.....|.:..:.:.....|||:.:|.|||.||..::..||
Mosquito   687 ATKVLGLVFFTFVFCWAPFFILNIIFAAWPEAKVPERIVSICLWLGYVSSTINPIIYTIFNKTFR 751

  Fly   603 AAFWRLTCKRFFSAGQKPQFPTNTMS 628
            |||.||...|...:|:.|::.:.|.|
Mosquito   752 AAFIRLLRCRCERSGRPPRYRSVTDS 777

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TyrR	NP_650652.1	7tmA_tyramine_R-like	118..>304	CDD:320189	76/191 (40%)
		TM helix 1	118..144	CDD:320189	10/25 (40%)
		TM helix 2	151..177	CDD:320189	15/25 (60%)
		TM helix 3	189..219	CDD:320189	16/29 (55%)
		TM helix 4	232..255	CDD:320189	9/23 (39%)
		TM helix 5	272..297	CDD:320189	8/24 (33%)
		7tm_GPCRs	<533..605	CDD:475119	26/71 (37%)
		TM helix 6	539..561	CDD:320189	10/21 (48%)
		TM helix 7	573..598	CDD:320189	9/24 (38%)
5-HT2A	XP_061500179.1	None