DRSC/TRiP Functional Genomics Resources

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Protein Alignment TyrR and Chrm1

DIOPT Version :10

Sequence 1:NP_650652.1 Gene:TyrR / 42136 FlyBaseID:FBgn0038542 Length:631 Species:Drosophila melanogaster
Sequence 2:NP_031724.2 Gene:Chrm1 / 12669 MGIID:88396 Length:460 Species:Mus musculus


Alignment Length:544 Identity:144/544 - (26%)
Similarity:220/544 - (40%) Gaps:147/544 - (27%)


- Green bases have known domain annotations that are detailed below.


  Fly   114 WQGIILIAVFATFIVVTVIGNTLVILAILTTRRLRTITNCFVMSLAVADLLVGIFVMPPAVAVHL 178
            ||...:........:.||.||.||:::......|:|:.|.|::|||.|||::|.|.|.......|
Mouse    23 WQVAFIGITTGLLSLATVTGNLLVLISFKVNTELKTVNNYFLLSLACADLIIGTFSMNLYTTYLL 87

  Fly   179 IGSWQLGWVLCDIWISLDVLLCTASILSLCAISVDRYLAVTRPLTYSRKRRSKRLALIMILIVWL 243
            :|.|.||.:.||:|::||.:...||:::|..||.|||.:|||||:|..||..:|.|| ||.:.||
Mouse    88 MGHWALGTLACDLWLALDYVASNASVMNLLLISFDRYFSVTRPLSYRAKRTPRRAAL-MIGLAWL 151

  Fly   244 LALAITCPPMLGW-YEPGRRDL--RECRYNQ--NEGYVIF-SAMGSFFIPMAVMIYVYARISCVI 302
            ::..:..|.:|.| |..|.|.:  .:| |.|  ::..:.| :||.:|::|:.||..:|.||    
Mouse   152 VSFVLWAPAILFWQYLVGERTVLAGQC-YIQFLSQPIITFGTAMAAFYLPVTVMCTLYWRI---- 211

  Fly   303 ASRHDNMTDISVHNKKFKRYTAADVENELSEQEQHSSVGQRQRQATSRTFSNQTIAKELQDMMLS 367
                                                     .|:..:|       |:||      
Mouse   212 -----------------------------------------YRETENR-------AREL------ 222

  Fly   368 DSDNCAAMGAGGAGGGGGGASSATGGTHCQSLLALPSGGVGGSMGCAKNGCYELTRPSSLKRA-- 430
                 ||:......|.|||:||::..:         ..|..||.......|....|...|.:|  
Mouse   223 -----AALQGSETPGKGGGSSSSSERS---------QPGAEGSPESPPGRCCRCCRAPRLLQAYS 273

  Fly   431 -------STASTTITTMTSGMGPGSS------LLDAQWQS---QPPGQTGQVQTHSLSQPPRTHS 479
                   ...|....|.:.|..|||.      ::|.:.|:   |||    :...:::.:|.:...
Mouse   274 WKEEEEEDEGSMESLTSSEGEEPGSEVVIKMPMVDPEAQAPTKQPP----KSSPNTVKRPTKKGR 334

  Fly   480 FRHSHGERDRERLRSHHHHPHYHHQAGVTTTSTSGNTSANTNSKSLSNRIT-SLKKENKTTQTLS 543
            .|...|::.|                               ..:.|:.|.| ||.||.|..:|||
Mouse   335 DRGGKGQKPR-------------------------------GKEQLAKRKTFSLVKEKKAARTLS 368

  Fly   544 IVVGGFIACWLPFFINYLITPFLAEHQASQMLAKALTWLGWFNSAINPFIYAFYSVDFRAAF--- 605
            .::..||..|.|:.|..|::.| .:....:.|.:...||.:.||.:||..||..:..||..|   
Mouse   369 AILLAFILTWTPYNIMVLVSTF-CKDCVPETLWELGYWLCYVNSTVNPMCYALCNKAFRDTFRLL 432

  Fly   606 ---------WRLTCKRFFSAGQKP 620
                     ||...||..|..:.|
Mouse   433 LLCRWDKRRWRKIPKRPGSVHRTP 456

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
TyrRNP_650652.1 7tmA_tyramine_R-like 118..>304 CDD:320189 71/191 (37%)
TM helix 1 118..144 CDD:320189 6/25 (24%)
TM helix 2 151..177 CDD:320189 11/25 (44%)
TM helix 3 189..219 CDD:320189 13/29 (45%)
TM helix 4 232..255 CDD:320189 8/22 (36%)
TM helix 5 272..297 CDD:320189 8/25 (32%)
7tm_GPCRs <533..605 CDD:475119 24/71 (34%)
TM helix 6 539..561 CDD:320189 8/21 (38%)
TM helix 7 573..598 CDD:320189 9/24 (38%)
Chrm1NP_031724.2 7tmA_mAChR_M1 26..429 CDD:341356 135/512 (26%)
TM helix 1 27..53 CDD:341356 6/25 (24%)
TM helix 2 60..86 CDD:341356 11/25 (44%)
TM helix 3 98..128 CDD:341356 13/29 (45%)
TM helix 4 140..163 CDD:341356 8/23 (35%)
TM helix 5 185..214 CDD:341356 10/73 (14%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 225..257 9/40 (23%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 274..297 3/22 (14%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 310..351 9/75 (12%)
TM helix 6 358..388 CDD:341356 12/29 (41%)
TM helix 7 397..422 CDD:341356 9/24 (38%)

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