Protein Alignment TyrR and LOC116411706

DIOPT Version :10

• Sequence 1: NP_650652.1
• Gene: TyrR / 42136
• FlyBaseID: FBgn0038542
• Length: 631
• Species: Drosophila melanogaster
• Sequence 2: XP_031760361.1
• Gene: LOC116411706 / 116411706
• XenbaseID: XB-GENE-29097575
• Length: 402
• Species: Xenopus tropicalis
• Alignment Length: 582
• Identity: 122/582 - (20%)
• Similarity: 202/582 - (34%)
• Gaps: 193/582 - (33%)

  Fly    44 NISIVYEDAGNGTGGGGVGGVGGGYPSGPNGTDAVALTEPGPTAPVTTFNYYNESAAAAEWAHFY 108
            |:.:|:..:||.|              ..|.|:...:...|..:|..|.
 Frog     9 NMKLVFSLSGNVT--------------NINQTNTSLVDVMGTQSPQITM---------------- 43

  Fly   109 DLVLSWQGIILIAVFATFIVVTVIGNTLVILAILTTRRLRTITNCFVMSLAVADLLVGIFVMPPA 173
                    |||:.|.:..|:|||:||||||||.:..||||..:|.|:::||:.|..:|.|.:|..
 Frog    44 --------IILVTVISCLILVTVLGNTLVILAFIEDRRLRNRSNFFLLNLAICDFFIGAFCIPFY 100

  Fly   174 VAVHLIGSWQLGWVLCDIWISLDVLLCTASILSLCAISVDRYLAVTRPLTYSRKRRSKRLALIMI 238
            |.....|.|.||..||.:|:.:|.|:||||..::..||.||:|:||..:.:....:.....::.:
 Frog   101 VPYVFTGKWLLGKFLCKLWLIVDNLMCTASAFNVVLISYDRFLSVTMAVLHRSIEKEHGRTVLNM 165

  Fly   239 LIVWLLALAITCPPMLGW-YEPGRRDLRECRYNQNEGYVIFSAMGS----FFIPMAVMIYVYARI 298
            .:||:||..:..|.::.| |..|.:.:..........|..:..:|:    |.:|:..:.:....:
 Frog   166 ALVWILASLLYSPAIIFWEYVDGDKSIPTDLCLPGYFYAWYFLLGASTFDFLLPLLSISFFNLSL 230

  Fly   299 SCVIASRHDNMTDISVHNKKFKRYTAADVENELSEQEQHSSVGQRQRQATSRTFSNQTIAKELQD 363
            .|.|.||                          |.::||.        .||...||.. ....:.
 Frog   231 YCNIRSR--------------------------SRKKQHI--------VTSPIDSNLD-GNPARP 260

  Fly   364 MMLSDSDNCAAMGAGGAGGGGGGASSATGGTHCQSLLALPSGGVGGSMGCAKNGCYELTRPSSLK 428
            .::|.:|                               ..:|.|           .:|..|...|
 Frog   261 YIISGND-------------------------------FHNGAV-----------KDLNTPQYKK 283

  Fly   429 RASTASTTITTMTSGMGPGSSLLDAQWQSQPPGQTGQVQTHSLSQPPRTHSFRHSHGERDRERLR 493
                ...::....|.:.|                              .|        ||::.:|
 Frog   284 ----GKRSLCCFFSNVLP------------------------------LH--------RDQQTVR 306

  Fly   494 SHHHHPHYHHQAGVTTTSTSGNTSANTNSKSLSNRITSLKKENKTTQTLSIVVGGFIACWLPFFI 558
            .:.|                               :..|.::.|..::||::|..|..||.|:.:
 Frog   307 YNVH-------------------------------VIKLSRDKKIAKSLSVLVCVFGMCWAPYSL 340

  Fly   559 NYLITPFLAEHQASQMLAKALTWLGWFNSAINPFIYAFYSVDFRAAFWRLTCKRFFSAGQKP 620
            ...|.....::...........||.|.||::|||:|......||.||.::..|...:...||
 Frog   341 LMTIRAACHDNCIDSYWYDITFWLLWINSSVNPFLYPLCHESFRKAFAKVFYKYIKNKNLKP 402

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TyrR	NP_650652.1	7tmA_tyramine_R-like	118..>304	CDD:320189	62/190 (33%)
		TM helix 1	118..144	CDD:320189	15/25 (60%)
		TM helix 2	151..177	CDD:320189	9/25 (36%)
		TM helix 3	189..219	CDD:320189	13/29 (45%)
		TM helix 4	232..255	CDD:320189	5/22 (23%)
		TM helix 5	272..297	CDD:320189	4/28 (14%)
		7tm_GPCRs	<533..605	CDD:475119	20/71 (28%)
		TM helix 6	539..561	CDD:320189	7/21 (33%)
		TM helix 7	573..598	CDD:320189	9/24 (38%)
LOC116411706	XP_031760361.1	7tmA_Histamine_H3R_H4R	44..387	CDD:320176	107/492 (22%)
		TM helix 1	45..71	CDD:320176	15/25 (60%)
		TM helix 2	78..105	CDD:320176	9/26 (35%)
		TM helix 3	116..146	CDD:320176	13/29 (45%)
		TM helix 4	161..179	CDD:320176	4/17 (24%)
		TM helix 5	204..234	CDD:320176	4/29 (14%)
		TM helix 6	315..345	CDD:320176	8/29 (28%)
		TM helix 7	355..380	CDD:320176	9/24 (38%)