DRSC/TRiP Functional Genomics Resources

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Protein Alignment TyrR and Adrb2

DIOPT Version :10

Sequence 1:NP_650652.1 Gene:TyrR / 42136 FlyBaseID:FBgn0038542 Length:631 Species:Drosophila melanogaster
Sequence 2:NP_031446.2 Gene:Adrb2 / 11555 MGIID:87938 Length:418 Species:Mus musculus


Alignment Length:553 Identity:133/553 - (24%)
Similarity:198/553 - (35%) Gaps:222/553 - (40%)


- Green bases have known domain annotations that are detailed below.


  Fly    71 GPNGTDAVALTEP-GPTAPVTTFNYYNESAAAAEWAHFYDLVLSWQGIILIAVFATFIVVTVI-G 133
            ||:|.|:..|..| |..||........:.|              |  ::.:|:..:.||:.:: |
Mouse     2 GPHGNDSDFLLAPNGSRAPDHDVTQERDEA--------------W--VVGMAILMSVIVLAIVFG 50

  Fly   134 NTLVILAILTTRRLRTITNCFVMSLAVADLLVGIFVMPPAVAVHLIGSWQLGWVLCDIWISLDVL 198
            |.|||.||....||:|:||.|::|||.|||::|:.|:|...:..|:..|..|...|:.|.|:|||
Mouse    51 NVLVITAIAKFERLQTVTNYFIISLACADLVMGLAVVPFGASHILMKMWNFGNFWCEFWTSIDVL 115

  Fly   199 LCTASILSLCAISVDRYLAVTRPLTYSRKRRSKRLALIMILIVWLLA-LAITCPPMLGWYEPGRR 262
            ..||||.:||.|:||||:|:|.|..| :...:|..|.::||:||::: |....|..:.||....:
Mouse   116 CVTASIETLCVIAVDRYVAITSPFKY-QSLLTKNKARVVILMVWIVSGLTSFLPIQMHWYRATHK 179

  Fly   263 DLRECRYNQ--------NEGYVIFSAMGSFFIPMAVMIYVYARISCVIASRHDNMTDISVHNKKF 319
            ...:| |.:        |:.|.|.|::.||::|:.||::||:|:                     
Mouse   180 KAIDC-YTEETCCDFFTNQAYAIASSIVSFYVPLVVMVFVYSRV--------------------- 222

  Fly   320 KRYTAADVENELSEQEQHSSVGQRQRQATSRTFSNQTIAKELQDMMLSDSDNCAAMGAGGAGGGG 384
                              ..|.:||.|...:                                  
Mouse   223 ------------------FQVAKRQLQKIDK---------------------------------- 235

  Fly   385 GGASSATGGTHCQSLLALPSGGVGGSMGCAKNGCYELTRPSSLKRASTASTTITTMTSGMGPGSS 449
                 :.|..|.|:|..:...|                                           
Mouse   236 -----SEGRFHAQNLSQVEQDG------------------------------------------- 252

  Fly   450 LLDAQWQSQPPGQTGQVQTHSLSQPPRTHSFRHSHGERDRERLRSHHHHPHYHHQAGVTTTSTSG 514
                                           |..||.|...:.                      
Mouse   253 -------------------------------RSGHGLRRSSKF---------------------- 264

  Fly   515 NTSANTNSKSLSNRITSLKKENKTTQTLSIVVGGFIACWLPFFINYLITPFLAEHQASQMLAKAL 579
                             ..||:|..:||.|::|.|..||||||| ..|...:.::...:.:...|
Mouse   265 -----------------CLKEHKALKTLGIIMGTFTLCWLPFFI-VNIVHVIRDNLIPKEVYILL 311

  Fly   580 TWLGWFNSAINPFIYAFYSVDFRAAFWRLTCKR 612
            .|||:.|||.||.||. .|.|||.||..|.|.|
Mouse   312 NWLGYVNSAFNPLIYC-RSPDFRIAFQELLCLR 343

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
TyrRNP_650652.1 7tmA_tyramine_R-like 118..>304 CDD:320189 73/195 (37%)
TM helix 1 118..144 CDD:320189 10/26 (38%)
TM helix 2 151..177 CDD:320189 12/25 (48%)
TM helix 3 189..219 CDD:320189 18/29 (62%)
TM helix 4 232..255 CDD:320189 7/23 (30%)
TM helix 5 272..297 CDD:320189 11/24 (46%)
7tm_GPCRs <533..605 CDD:475119 31/71 (44%)
TM helix 6 539..561 CDD:320189 12/21 (57%)
TM helix 7 573..598 CDD:320189 11/24 (46%)
Adrb2NP_031446.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..23 9/20 (45%)
7tmA_Beta2_AR 34..336 CDD:341355 117/496 (24%)
TM helix 1 35..61 CDD:341355 10/25 (40%)
TM helix 2 68..95 CDD:341355 12/26 (46%)
TM helix 3 106..136 CDD:341355 18/29 (62%)
TM helix 4 148..171 CDD:341355 7/22 (32%)
TM helix 5 196..228 CDD:341355 13/70 (19%)
TM helix 6 266..296 CDD:341355 16/30 (53%)
TM helix 7 305..330 CDD:341355 11/25 (44%)
PDZ-binding 415..418
Blue background indicates that the domain is not in the aligned region.

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