Protein Alignment TyrR and Adra2c

DIOPT Version :9

• Sequence 1: NP_001287381.1
• Gene: TyrR / 42136
• FlyBaseID: FBgn0038542
• Length: 631
• Species: Drosophila melanogaster
• Sequence 2: NP_031444.2
• Gene: Adra2c / 11553
• MGIID: 87936
• Length: 458
• Species: Mus musculus
• Alignment Length: 569
• Identity: 168/569 - (29%)
• Similarity: 241/569 - (42%)
• Gaps: 139/569 - (24%)

  Fly    52 AGNGTGGGGVGGVGGGYPSGPNGTDAVALTEPGPTAPVTTFNYYNESAAAAEWAHFYDLVLSWQG 116
            |..|..|...|..|.|..:..:|||.|    |.|       ..|:..|.|.
Mouse    14 AAEGPNGSDAGEWGSGGGANASGTDWV----PPP-------GQYSAGAVAG-------------- 53

  Fly   117 IILIAVFATFIVVTVIGNTLVILAILTTRRLRTITNCFVMSLAVADLLVGIFVMPPAVAVHLIGS 181
              |.||....||.||:||.||::|:||:|.||...|.|::|||.||:||...|||.::|..|:..
Mouse    54 --LAAVVGFLIVFTVVGNVLVVIAVLTSRALRAPQNLFLVSLASADILVATLVMPFSLANELMAY 116

  Fly   182 WQLGWVLCDIWISLDVLLCTASILSLCAISVDRYLAVTRPLTYSRKRRSKRLALIMILIVWLLAL 246
            |..|.|.|.::::||||.||:||:.|||||:|||.:||:.:.|:.||..:|:. ..|:.|||::.
Mouse   117 WYFGQVWCGVYLALDVLFCTSSIVHLCAISLDRYWSVTQAVEYNLKRTPRRVK-ATIVAVWLISA 180

  Fly   247 AITCPPMLGWY-EPGRRDLRECRYNQNEGYVIFSAMGSFFIPMAVMIYVYARISCVIASRHDNMT 310
            .|:.||::.:| .|......:|..|....|::.|.:||||.|..:|..|||||..|...|...::
Mouse   181 VISFPPLVSFYRRPDGAAYPQCGLNDETWYILSSCIGSFFAPCLIMGLVYARIYRVAKLRTRTLS 245

  Fly   311 DISVHNKKFKRYTAA-DVENELSEQEQHSSVGQRQRQATSRTFSNQTIAKELQDMMLSDSDNCAA 374
            :        ||..|. |..:..:|.....:.|:....|..||        |::....|.::....
Mouse   246 E--------KRGPAGPDGASPTTENGLGKAAGENGHCAPPRT--------EVEPDESSAAERRRR 294

  Fly   375 MGA---GG--AGGGGGGASSATGGTHCQSLLALPSGGVGGSMGCAKNGCYELTRPSSLKRASTAS 434
            .||   ||  ..|..|...||.|          |..|:....|                 |.|||
Mouse   295 RGALRRGGRRREGAEGDTGSADG----------PGPGLAAEQG-----------------ARTAS 332

  Fly   435 TTITTMTSGMGPGSSLLDAQWQSQPPGQTGQVQTHSLSQPPRTHSFRHSHGERDRERLRSHHHHP 499
            .:       .|||..|..|.                    .|:..|..|.    |.|.||
Mouse   333 RS-------PGPGGRLSRAS--------------------SRSVEFFLSR----RRRARS----- 361

  Fly   500 HYHHQAGVTTTSTSGNTSANTNSKSLSNRITSLKKENKTTQTLSIVVGGFIACWLPFFINYLITP 564
                                    |:..|..:..:|.:.|..|::|:|.|:.||.|||.:|.:..
Mouse   362 ------------------------SVCRRKVAQAREKRFTFVLAVVMGVFVLCWFPFFFSYSLYG 402

  Fly   565 FLAEH-QASQMLAKALTWLGWFNSAINPFIYAFYSVDFRAAFWRLTCKR 612
            ...|. |..:.|.|...|:|:.||::||.||..::.|||.:|..:..:|
Mouse   403 ICREACQLPEPLFKFFFWIGYCNSSLNPVIYTVFNQDFRRSFKHILFRR 451

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TyrR	NP_001287381.1	7tm_4	127..>249	CDD:304433	58/121 (48%)
		7tm_1	133..>298	CDD:278431	72/165 (44%)
Adra2c	NP_031444.2	7tmA_alpha2C_AR	60..444	CDD:320446	148/487 (30%)
		TM helix 2	86..112	CDD:320446	13/25 (52%)
		TM helix 3	124..154	CDD:320446	17/29 (59%)
		TM helix 4	166..189	CDD:320446	8/23 (35%)
		TM helix 5	207..236	CDD:320446	13/28 (46%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	245..343		31/147 (21%)
		TM helix 6	371..401	CDD:320446	12/29 (41%)
		TM helix 7	412..437	CDD:320446	10/24 (42%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910