Protein Alignment TyrR and Adra2b

DIOPT Version :10

• Sequence 1: NP_650652.1
• Gene: TyrR / 42136
• FlyBaseID: FBgn0038542
• Length: 631
• Species: Drosophila melanogaster
• Sequence 2: NP_033763.3
• Gene: Adra2b / 11552
• MGIID: 87935
• Length: 448
• Species: Mus musculus
• Alignment Length: 532
• Identity: 157/532 - (29%)
• Similarity: 226/532 - (42%)
• Gaps: 119/532 - (22%)

  Fly   113 SWQGIILIAVFATFIVV-TVIGNTLVILAILTTRRLRTITNCFVMSLAVADLLVGIFVMPPAVAV 176
            |.|....||...||::: |:.||.|||||:||:|.||...|.|::|||.||:||...::|.::|.
Mouse     8 SVQATAAIASAITFLILFTIFGNALVILAVLTSRSLRAPQNLFLVSLAAADILVATLIIPFSLAN 72

  Fly   177 HLIGSWQLGWVLCDIWISLDVLLCTASILSLCAISVDRYLAVTRPLTYSRKRRSKRLALIMILIV 241
            .|:|.|......|:::::||||.||:||:.|||||:|||.||:|.|.|:.||..:|:..| ||.|
Mouse    73 ELLGYWYFWRAWCEVYLALDVLFCTSSIVHLCAISLDRYWAVSRALEYNSKRTPRRIKCI-ILTV 136

  Fly   242 WLLALAITCPPML--GWYEPGRRDLRECRYNQNEGYVIFSAMGSFFIPMAVMIYVYARISCVIAS 304
            ||:|..|:.||::  |...|....|.:|..||...|::.|::||||.|..:||.||.|| .|||.
Mouse   137 WLIAAVISLPPLIYKGDQRPEPHGLPQCELNQEAWYILASSIGSFFAPCLIMILVYLRI-YVIAK 200

  Fly   305 RHDNMTDISVHNKKFKRYTAADVENELSEQEQHSSVGQRQRQATSRTFSNQTIAKELQDMMLSDS 369
            |
Mouse   201 R---------------------------------------------------------------- 201

  Fly   370 DNCAAMGAGGAGGGGGGASS----ATGGTHCQS---LLALPSGGVGGSMGCAKNGCYELTRPSSL 427
            .:|..:||  ..|.|.|.|.    |.||....:   .|..|...||.:.|          .|...
Mouse   202 SHCRGLGA--KRGSGEGESKKPHPAAGGVPASAKVPTLVSPLSSVGEANG----------HPKPP 254

  Fly   428 KRASTASTTITTMTSGMGPGSSLLDAQWQSQPPGQTGQVQTHSLSQPPRTHSFRHSHGERDRERL 492
            :......|........:.|..|.|....|.|..|.:|              :......|.|.|.:
Mouse   255 REKEEGETPEDPEARALPPNWSALPRSVQDQKKGTSG--------------ATAEKGAEEDEEEV 305

  Fly   493 R------------SHHHHPHYHHQAGVTTTSTSGNTSANTN----SKSLSNRITSLKKENKTTQT 541
            .            |..:.|....|......:..|....:.|    |.....|.|.|.:|.:.|..
Mouse   306 EECEPQTLPASPASVFNPPLQQPQTSRVLATLRGQVLLSKNVGVASGQWWRRRTQLSREKRFTFV 370

  Fly   542 LSIVVGGFIACWLPFFINYLITPFLAEH-QASQMLAKALTWLGWFNSAINPFIYAFYSVDFRAAF 605
            |::|:|.|:.||.|||.:|.:.....:| :....|.:...|:|:.||::||.||..::.|||.||
Mouse   371 LAVVIGVFVVCWFPFFFSYSLGAICPQHCKVPHGLFQFFFWIGYCNSSLNPVIYTIFNQDFRRAF 435

  Fly   606 WRLTCKRFFSAG 617
            .|:.|:::...|
Mouse   436 RRILCRQWTQTG 447

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TyrR	NP_650652.1	7tmA_tyramine_R-like	118..>304	CDD:320189	87/188 (46%)
		TM helix 1	118..144	CDD:320189	13/26 (50%)
		TM helix 2	151..177	CDD:320189	11/25 (44%)
		TM helix 3	189..219	CDD:320189	18/29 (62%)
		TM helix 4	232..255	CDD:320189	11/24 (46%)
		TM helix 5	272..297	CDD:320189	11/24 (46%)
		7tm_GPCRs	<533..605	CDD:475119	25/72 (35%)
		TM helix 6	539..561	CDD:320189	10/21 (48%)
		TM helix 7	573..598	CDD:320189	9/24 (38%)
Adra2b	NP_033763.3	TM helix 3	85..115	CDD:320444	18/29 (62%)
		TM helix 4	127..150	CDD:320444	11/23 (48%)
		TM helix 5	169..198	CDD:320444	13/29 (45%)
		TM helix 6	362..392	CDD:320444	12/29 (41%)
		TM helix 7	403..428	CDD:320444	9/24 (38%)
		7tmA_alpha2B_AR	7..435	CDD:320444	152/518 (29%)
		TM helix 1	14..40	CDD:320444	13/25 (52%)
		TM helix 2	47..73	CDD:320444	11/25 (44%)