DRSC/TRiP Functional Genomics Resources

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Protein Alignment TyrR and Adra2a

DIOPT Version :10

Sequence 1:NP_650652.1 Gene:TyrR / 42136 FlyBaseID:FBgn0038542 Length:631 Species:Drosophila melanogaster
Sequence 2:NP_031443.4 Gene:Adra2a / 11551 MGIID:87934 Length:465 Species:Mus musculus


Alignment Length:606 Identity:165/606 - (27%)
Similarity:239/606 - (39%) Gaps:179/606 - (29%)


- Green bases have known domain annotations that are detailed below.


  Fly    30 LGLGSGVGVGGLPENISIVYEDAGNGTGGGGVGGVGGGYPSGPNGTDAVALTEPGPTAPVTTFNY 94
            |..||...:|.|       ..||||               |..|||:|     ||.....|.   
Mouse     8 LAEGSFAPMGSL-------QPDAGN---------------SSWNGTEA-----PGGGTRATP--- 42

  Fly    95 YNESAAAAEWAHFYDLVLSWQGIILIAVFATFIVVTVIGNTLVILAILTTRRLRTITNCFVMSLA 159
                         |.|.::   :.|:.:....::.||.||.|||:|:.|:|.|:...|.|::|||
Mouse    43 -------------YSLQVT---LTLVCLAGLLMLFTVFGNVLVIIAVFTSRALKAPQNLFLVSLA 91

  Fly   160 VADLLVGIFVMPPAVAVHLIGSWQLGWVLCDIWISLDVLLCTASILSLCAISVDRYLAVTRPLTY 224
            .||:||...|:|.::|..::|.|..|.|.|:|:::||||.||:||:.|||||:|||.::|:.:.|
Mouse    92 SADILVATLVIPFSLANEVMGYWYFGKVWCEIYLALDVLFCTSSIVHLCAISLDRYWSITQAIEY 156

  Fly   225 SRKRRSKRLALIMILIVWLLALAITCPPML--------GWYEPGRRDLRECRYNQNEGYVIFSAM 281
            :.||..:|:..| |:.||:::..|:.||::        |..:|..   ..|:.|..:.|||.|::
Mouse   157 NLKRTPRRIKAI-IVTVWVISAVISFPPLISIEKKGAGGGQQPAE---PSCKINDQKWYVISSSI 217

  Fly   282 GSFFIPMAVMIYVYARISCVIASRHDNMTDISVHNKKFKRYTAADVENELSEQEQHSSVGQRQRQ 346
            ||||.|..:||.||.||                       |..|.               :|.|.
Mouse   218 GSFFAPCLIMILVYVRI-----------------------YQIAK---------------RRTRV 244

  Fly   347 ATSRTFSNQTIAKELQDMMLSDSDNCAAMGAGGA----GGGGGGASSATGGTHCQSLLALPSGGV 407
            ..||                ...|.|:| ..|||    .|.|....:...|...:.|....:|..
Mouse   245 PPSR----------------RGPDACSA-PPGGADRRPNGLGPERGAGPTGAEAEPLPTQLNGAP 292

  Fly   408 G--GSMGCAKNGCYELTRPSSLKRAST----------ASTTITTMTSGMGPGSSLLDAQWQSQPP 460
            |  ...|.......:|...||.:.|..          ......|..|.:.||.||     ..:.|
Mouse   293 GEPAPAGPRDGDALDLEESSSSEHAERPPGPRRPDRGPRAKGKTRASQVKPGDSL-----PRRGP 352

  Fly   461 GQTGQVQTHSLSQPPRTHSFRHSHGERDRERLRSHHHHPHYHHQAGVTTTSTSGNTSANTNSKSL 525
            |..|...:.|            .|||   ||                      |..:..:..:..
Mouse   353 GAAGPGASGS------------GHGE---ER----------------------GGGAKASRWRGR 380

  Fly   526 SNRITSLKKENKTTQTLSIVVGGFIACWLPFFINYLITPFLAEHQASQMLAKALTWLGWFNSAIN 590
            .||      |.:.|..|::|:|.|:.||.|||..|  |...........|.....|.|:.||::|
Mouse   381 QNR------EKRFTFVLAVVIGVFVVCWFPFFFTY--TLIAVGCPVPSQLFNFFFWFGYCNSSLN 437

  Fly   591 PFIYAFYSVDFRAAFWRLTCK 611
            |.||..::.|||.||.::.|:
Mouse   438 PVIYTIFNHDFRRAFKKILCR 458

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
TyrRNP_650652.1 7tmA_tyramine_R-like 118..>304 CDD:320189 77/193 (40%)
TM helix 1 118..144 CDD:320189 9/25 (36%)
TM helix 2 151..177 CDD:320189 12/25 (48%)
TM helix 3 189..219 CDD:320189 18/29 (62%)
TM helix 4 232..255 CDD:320189 8/30 (27%)
TM helix 5 272..297 CDD:320189 13/24 (54%)
7tm_GPCRs <533..605 CDD:475119 25/71 (35%)
TM helix 6 539..561 CDD:320189 10/21 (48%)
TM helix 7 573..598 CDD:320189 9/24 (38%)
Adra2aNP_031443.4 7tmA_alpha2A_AR 49..452 CDD:320445 143/511 (28%)
TM helix 1 50..76 CDD:320445 9/25 (36%)
TM helix 2 83..109 CDD:320445 12/25 (48%)
TM helix 3 121..151 CDD:320445 18/29 (62%)
TM helix 4 163..186 CDD:320445 8/23 (35%)
TM helix 5 208..237 CDD:320445 16/51 (31%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 242..378 36/194 (19%)
TM helix 6 382..412 CDD:320445 15/37 (41%)
TM helix 7 420..445 CDD:320445 9/24 (38%)

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