Protein Alignment TyrR and Adra1d

DIOPT Version :10

• Sequence 1: NP_650652.1
• Gene: TyrR / 42136
• FlyBaseID: FBgn0038542
• Length: 631
• Species: Drosophila melanogaster
• Sequence 2: NP_038488.4
• Gene: Adra1d / 11550
• MGIID: 106673
• Length: 562
• Species: Mus musculus
• Alignment Length: 602
• Identity: 172/602 - (28%)
• Similarity: 238/602 - (39%)
• Gaps: 212/602 - (35%)

  Fly    23 SSSSLRGLGLGSGVG--------VGGLPENISIVYEDAGNGTGGGGVGGVGGGYPSGPNGTDAVA 79
            :|||..|.|.|.|.|        |||:|           ..|||..|.|.|    ||.:...:.|
Mouse    16 ASSSTGGSGAGGGAGTVGPEGPAVGGVP-----------GATGGSAVVGTG----SGEDNQSSTA 65

  Fly    80 LTEPGPTAPVTTFNYYNESAAAAEWAHFYDLVLSWQGIILIAVFATFIVVTVIGNTLVILAILTT 144
              |.|..|.    ...|.|||..      .||:|.||:.:....|.||:..|.||.||||::...
Mouse    66 --EAGAAAS----GEVNGSAAVG------GLVVSAQGVGVGVFLAAFILTAVAGNLLVILSVACN 118

  Fly   145 RRLRTITNCFVMSLAVADLLVGIFVMPPAVAVHLIGSWQLGWVLCDIWISLDVLLCTASILSLCA 209
            |.|:|:||.|:::|||||||:...|:|.:..:.::|.|..|...||:|.::|||.|||||||||.
Mouse   119 RHLQTVTNYFIVNLAVADLLLSAAVLPFSATMEVLGFWAFGRTFCDVWAAVDVLCCTASILSLCT 183

  Fly   210 ISVDRYLAVTRPLTYSRKRRSKRLALIMILIVWLLALAITCPPMLGWYEPGRRDLRECRYNQNEG 274
            ||||||:.|...|.|......::.|.|:.|: |.:||.::..|:|||.||...|.|.|...:..|
Mouse   184 ISVDRYVGVRHSLKYPAIMTERKAAAILALL-WAVALVVSVGPLLGWKEPVPPDERFCGITEEVG 247

  Fly   275 YVIFSAMGSFFIPMAVMIYVYARISCVIASRHDNMTDISVHNKKFKRYTAADVENELSEQEQHSS 339
            |.|||::.||::||||::.:|.|:                       |..|
Mouse   248 YAIFSSVCSFYLPMAVIVVMYCRV-----------------------YVVA-------------- 275

  Fly   340 VGQRQRQATSRTFSNQTIAKELQDMMLSDSDNCAAMGAGGAGGGGGGASSATGGTHCQSLLALPS 404
                  ::|:|:..                        .|.....|.||......||:
Mouse   276 ------RSTTRSLE------------------------AGIKREPGKASEVVLRIHCR------- 303

  Fly   405 GGVGGSMGCAKNGCYELTRPSSLKRASTASTTITTMTSGMG-PGSSLLDAQWQSQPPGQTGQVQT 468
                   |.|                          ||..| ||
Mouse   304 -------GAA--------------------------TSAKGNPG--------------------- 314

  Fly   469 HSLSQPPRTHSFRHSHGERDRERLRSHHHHPHYHHQAGVTTTSTSGNTSANTNSKSLSNRITSLK 533
                                                    |.|:.|:|..:    |||.|:....
Mouse   315 ----------------------------------------TQSSKGHTLRS----SLSVRLLKFS 335

  Fly   534 KENKTTQTLSIVVGGFIACWLPFFINYLITPFLAEHQASQMLAKALTWLGWFNSAINPFIYAFYS 598
            :|.|..:||:||||.|:.||.|||....:.....:.:.|:.:.|.:.|||:|||.:||.||...|
Mouse   336 REKKAAKTLAIVVGVFVLCWFPFFFVLPLGSLFPQLKPSEGVFKVIFWLGYFNSCVNPLIYPCSS 400

  Fly   599 VDFRAAFWRL---TCKR 612
            .:|:.||.||   .|:|
Mouse   401 REFKRAFLRLLRCQCRR 417

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TyrR	NP_650652.1	7tmA_tyramine_R-like	118..>304	CDD:320189	80/185 (43%)
		TM helix 1	118..144	CDD:320189	10/25 (40%)
		TM helix 2	151..177	CDD:320189	12/25 (48%)
		TM helix 3	189..219	CDD:320189	21/29 (72%)
		TM helix 4	232..255	CDD:320189	7/22 (32%)
		TM helix 5	272..297	CDD:320189	12/24 (50%)
		7tm_GPCRs	<533..605	CDD:475119	28/71 (39%)
		TM helix 6	539..561	CDD:320189	12/21 (57%)
		TM helix 7	573..598	CDD:320189	11/24 (46%)
Adra1d	NP_038488.4	7tm_GPCRs	91..407	CDD:475119	133/488 (27%)
		TM helix 1	93..117	CDD:410628	10/23 (43%)
		TM helix 2	126..148	CDD:410628	11/21 (52%)
		TM helix 3	164..186	CDD:410628	15/21 (71%)
		TM helix 4	209..225	CDD:410628	5/16 (31%)
		TM helix 5	246..269	CDD:410628	11/22 (50%)
		TM helix 6	341..363	CDD:410628	12/21 (57%)
		TM helix 7	375..400	CDD:410628	11/24 (46%)