Protein Alignment TyrR and Adra1a

DIOPT Version :10

• Sequence 1: NP_650652.1
• Gene: TyrR / 42136
• FlyBaseID: FBgn0038542
• Length: 631
• Species: Drosophila melanogaster
• Sequence 2: NP_038489.2
• Gene: Adra1a / 11549
• MGIID: 104773
• Length: 466
• Species: Mus musculus
• Alignment Length: 504
• Identity: 129/504 - (25%)
• Similarity: 193/504 - (38%)
• Gaps: 187/504 - (37%)

  Fly   115 QGIILIAVFATFIVVTVIGNTLVILAILTTRRLRTITNCFVMSLAVADLLVGIFVMPPAVAVHLI 179
            :.|:|..:....|:..|:||.||||::...|.|.::|:.::::|||||||:...|:|.:....::
Mouse    25 KAILLGVILGGLIIFGVLGNILVILSVACHRHLHSVTHYYIVNLAVADLLLTSTVLPFSAIFEIL 89

  Fly   180 GSWQLGWVLCDIWISLDVLLCTASILSLCAISVDRYLAVTRPLTYS---RKRRSKRLALIMILIV 241
            |.|..|.|.|:||.::|||.|||||:.||.||:|||:.|:.||.|.   .:||..|    .:|.|
Mouse    90 GYWAFGRVFCNIWAAVDVLCCTASIMGLCIISIDRYIGVSYPLRYPTIVTQRRGVR----ALLCV 150

  Fly   242 WLLALAITCPPMLGWYEPGRRDLRECRYNQNEGYVIFSAMGSFFIPMAVMIYVYARISCVIASRH 306
            |.|:|.|:..|:.||.:....|...|:.|:..|||:|||:|||::|:.:::.:|.|: .|:|.|.
Mouse   151 WALSLVISIGPLFGWRQQAPEDETICQINEEPGYVLFSALGSFYVPLTIILVMYCRV-YVVAKRE 214

  Fly   307 DNMTDISVHNKKFKRYTAADVENELSEQEQHSSVGQRQRQATSRTFSNQTIAKELQDMMLSDSDN 371
                         .|...:.::.:.|:.|          |.|.|.......|:
Mouse   215 -------------SRGLKSGLKTDKSDSE----------QVTLRIHRKNVPAE------------ 244

  Fly   372 CAAMGAGGAGGGGGGASSATGGTHCQSLLALPSGGVGGSMGCAKNGCYELTRPSSLKRASTASTT 436
                        |.|.|||...||
Mouse   245 ------------GSGVSSAKNKTH----------------------------------------- 256

  Fly   437 ITTMTSGMGPGSSLLDAQWQSQPPGQTGQVQTHSLSQPPRTHSFRHSHGERDRERLRSHHHHPHY 501
                                                                             
Mouse   257 ----------------------------------------------------------------- 256

  Fly   502 HHQAGVTTTSTSGNTSANTNSKSLSNRITSLKKENKTTQTLSIVVGGFIACWLPFFINYLITPFL 566
                                   .|.|:....:|.|..:||.||||.|:.||||||:...|..|.
Mouse   257 -----------------------FSVRLLKFSREKKAAKTLGIVVGCFVLCWLPFFLVMPIGSFF 298

  Fly   567 AEHQASQMLAKALTWLGWFNSAINPFIYAFYSVDFRAAF---WRLTCKR 612
            ...:..:.:.|.:.|||:.||.|||.||...|.:|:.||   .|:.|.|
Mouse   299 PNFKPPETVFKIVFWLGYLNSCINPIIYPCSSQEFKKAFQNVLRIQCLR 347

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TyrR	NP_650652.1	7tmA_tyramine_R-like	118..>304	CDD:320189	75/188 (40%)
		TM helix 1	118..144	CDD:320189	9/25 (36%)
		TM helix 2	151..177	CDD:320189	10/25 (40%)
		TM helix 3	189..219	CDD:320189	18/29 (62%)
		TM helix 4	232..255	CDD:320189	8/22 (36%)
		TM helix 5	272..297	CDD:320189	11/24 (46%)
		7tm_GPCRs	<533..605	CDD:475119	30/71 (42%)
		TM helix 6	539..561	CDD:320189	13/21 (62%)
		TM helix 7	573..598	CDD:320189	11/24 (46%)
Adra1a	NP_038489.2	7tmA_alpha1A_AR	27..337	CDD:320448	124/490 (25%)
		TM helix 1	28..54	CDD:320448	9/25 (36%)
		TM helix 2	61..87	CDD:320448	10/25 (40%)
		TM helix 3	99..129	CDD:320448	18/29 (62%)
		TM helix 4	141..164	CDD:320448	10/26 (38%)
		TM helix 5	181..210	CDD:320448	12/29 (41%)
		TM helix 6	265..295	CDD:320448	15/29 (52%)
		TM helix 7	305..330	CDD:320448	11/24 (46%)
		Nuclear localization signal. /evidence=ECO:0000250	334..349		5/14 (36%)