Protein Alignment TyrR and Adora2b

DIOPT Version :10

• Sequence 1: NP_650652.1
• Gene: TyrR / 42136
• FlyBaseID: FBgn0038542
• Length: 631
• Species: Drosophila melanogaster
• Sequence 2: NP_031439.2
• Gene: Adora2b / 11541
• MGIID: 99403
• Length: 332
• Species: Mus musculus
• Alignment Length: 537
• Identity: 105/537 - (19%)
• Similarity: 172/537 - (32%)
• Gaps: 228/537 - (42%)

  Fly   112 LSWQGIILIAVFATFIVVTVIGNTLVILAILTTRRLRTITNCFVMSLAVADLLVGIFVMPPAVAV 176
            |..|..:.:|:......:.|.||.||..|:..:..|:|.||.|::|||.||:.||:|.:|.|:.:
Mouse     3 LETQDALYVALELVIAALAVAGNVLVCAAVGASSALQTPTNYFLVSLATADVAVGLFAIPFAITI 67

  Fly   177 HLIGSWQLGWVL----CDIWISLDVLLCT-ASILSLCAISVDRYLAVTRPLTYSRKRRSKRLALI 236
                  .||:..    | ::::..||:.| :||.||.|::||||||:..||.|.......| |..
Mouse    68 ------SLGFCTDFHGC-LFLACFVLVLTQSSIFSLLAVAVDRYLAIRVPLRYKGLVTGTR-ARG 124

  Fly   237 MILIVWLLALAITCPPMLGWYEPGRRDLRECRYNQ------NEGYVIFSAMGSFFIPMAVMIYVY 295
            :|.::|:||..|...|.|||   ..:|.......:      |:.....:.:....:||:.|:| :
Mouse   125 IIAVLWVLAFGIGLTPFLGW---NSKDSATSNCTELGDGIANKSCCPVTCLFENVVPMSYMVY-F 185

  Fly   296 ARISCVIASRHDNMTDISVHNKKFKRYTAADVENELSEQEQHSSVGQRQRQATSRTFSNQTIAKE 360
            ....||:...   :..:.::.|.|                                   ....|:
Mouse   186 NFFGCVLPPL---LIMLVIYIKIF-----------------------------------MVACKQ 212

  Fly   361 LQDMMLSDSDNCAAMGAGGAGGGGGGASSATGGTHCQSLLALPSGGVGGSMGCAKNGCYELTRPS 425
            ||.|.|.|
Mouse   213 LQRMELMD--------------------------------------------------------- 220

  Fly   426 SLKRASTASTTITTMTSGMGPGSSLLDAQWQSQPPGQTGQVQTHSLSQPPRTHSFRHSHGERDRE 490
                                                                    ||.
Mouse   221 --------------------------------------------------------HSR------ 223

  Fly   491 RLRSHHHHPHYHHQAGVTTTSTSGNTSANTNSKSLSNRITSLKKENKTTQTLSIVVGGFIACWLP 555
                                                   |:|::|....::|:::||.|..||||
Mouse   224 ---------------------------------------TTLQREIHAAKSLAMIVGIFALCWLP 249

  Fly   556 FFINYLIT---PFLAEHQASQMLAKALTWLGWFNSAINPFIYAFYSVDFRAAFWRL-----TCKR 612
            ......||   |.||:.:...::..|:. |...||.:||.:||:.:.|||.:|.::     .|:.
Mouse   250 VHAINCITLFHPALAKDKPKWVMNVAIL-LSHANSVVNPIVYAYRNRDFRYSFHKIISRYVLCQA 313

  Fly   613 FFSAGQKPQFPTNTMSI 629
            ....|.......:|:|:
Mouse   314 ETKGGSGQAGAQSTLSL 330

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TyrR	NP_650652.1	7tmA_tyramine_R-like	118..>304	CDD:320189	61/196 (31%)
		TM helix 1	118..144	CDD:320189	7/25 (28%)
		TM helix 2	151..177	CDD:320189	13/25 (52%)
		TM helix 3	189..219	CDD:320189	15/30 (50%)
		TM helix 4	232..255	CDD:320189	8/22 (36%)
		TM helix 5	272..297	CDD:320189	5/24 (21%)
		7tm_GPCRs	<533..605	CDD:475119	25/74 (34%)
		TM helix 6	539..561	CDD:320189	8/21 (38%)
		TM helix 7	573..598	CDD:320189	8/24 (33%)
Adora2b	NP_031439.2	7tmA_Adenosine_R_A2B	8..301	CDD:320197	98/501 (20%)
		TM helix 1	9..35	CDD:320197	7/25 (28%)
		TM helix 2	42..69	CDD:320197	13/32 (41%)
		TM helix 3	78..108	CDD:320197	15/30 (50%)
		TM helix 4	122..140	CDD:320197	6/17 (35%)
		TM helix 5	179..209	CDD:320197	7/68 (10%)
		TM helix 6	227..257	CDD:320197	9/29 (31%)
		TM helix 7	269..294	CDD:320197	8/25 (32%)