Protein Alignment TyrR and CHRM5

DIOPT Version :10

• Sequence 1: NP_650652.1
• Gene: TyrR / 42136
• FlyBaseID: FBgn0038542
• Length: 631
• Species: Drosophila melanogaster
• Sequence 2: NP_036257.1
• Gene: CHRM5 / 1133
• HGNCID: 1954
• Length: 532
• Species: Homo sapiens
• Alignment Length: 550
• Identity: 153/550 - (27%)
• Similarity: 234/550 - (42%)
• Gaps: 116/550 - (21%)

  Fly   114 WQGIILIAVFATFIVVTVIGNTLVILAILTTRRLRTITNCFVMSLAVADLLVGIFVMPPAVAVHL 178
            |:.|.:.||.|...::|::||.||:::.....:|:|:.|.:::|||.|||::|||.|.......|
Human    28 WEVITIAAVTAVVSLITIVGNVLVMISFKVNSQLKTVNNYYLLSLACADLIIGIFSMNLYTTYIL 92

  Fly   179 IGSWQLGWVLCDIWISLDVLLCTASILSLCAISVDRYLAVTRPLTYSRKRRSKRLALIMILIVWL 243
            :|.|.||.:.||:|::||.:...||:::|..||.|||.::||||||..||..|| |.|||.:.||
Human    93 MGRWALGSLACDLWLALDYVASNASVMNLLVISFDRYFSITRPLTYRAKRTPKR-AGIMIGLAWL 156

  Fly   244 LALAITCPPMLGW-YEPGRR--DLRECRYN-QNEGYVIF-SAMGSFFIPMAVMIYVYARISCVIA 303
            ::..:..|.:|.| |..|:|  .|.||:.. .:|..:.| :|:.:|:||::||..:|.||.....
Human   157 ISFILWAPAILCWQYLVGKRTVPLDECQIQFLSEPTITFGTAIAAFYIPVSVMTILYCRIYRETE 221

  Fly   304 SRHDNMTDI----SVHNKKFKRYTAADVENELSEQEQHSSVGQRQRQATSRTFSNQTIAKELQDM 364
            .|..::.|:    || .|..||..|.........:....::.||:|...|.:.|.:
Human   222 KRTKDLADLQGSDSV-TKAEKRKPAHRALFRSCLRCPRPTLAQRERNQASWSSSRR--------- 276

  Fly   365 MLSDSDNCAAMGAGGAGGGGGGASSATGGTHCQSLLALPSGGVGGSMGCAKNGCYELTRPSSLKR 429
                                  ::|.||         .||...|.|...||  ..:||..||...
Human   277 ----------------------STSTTG---------KPSQATGPSANWAK--AEQLTTCSSYPS 308

  Fly   430 ASTASTTITTMTSGMGPGSSLLDAQWQSQPPGQTGQVQTHSLSQPPRTHSFRHSHGERDRERLRS 494
            :.......|         ..:|...::||.....|:    ..|......:|..:..|      :|
Human   309 SEDEDKPAT---------DPVLQVVYKSQGKESPGE----EFSAEETEETFVKAETE------KS 354

  Fly   495 HHHHPHY-------HH---QAGVT-----TTSTSGNTSANT------------------NSKSL- 525
            .:..|:|       |.   |..|.     .....||...|.                  ::|.|
Human   355 DYDTPNYLLSPAAAHRPKSQKCVAYKFRLVVKADGNQETNNGCHKVKIMPCPFPVAKEPSTKGLN 419

  Fly   526 ---SNRITSLK-----KENKTTQTLSIVVGGFIACWLPFFINYLITPFLAEHQASQMLAKALTWL 582
               |:::|..|     ||.|..||||.::..||..|.|:.|..|::.| .:......|.....||
Human   420 PNPSHQMTKRKRVVLVKERKAAQTLSAILLAFIITWTPYNIMVLVSTF-CDKCVPVTLWHLGYWL 483

  Fly   583 GWFNSAINPFIYAFYSVDFRAAF-WRLTCK 611
            .:.||.:||..||..:..||..| ..|.|:
Human   484 CYVNSTVNPICYALCNRTFRKTFKMLLLCR 513

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TyrR	NP_650652.1	7tmA_tyramine_R-like	118..>304	CDD:320189	75/190 (39%)
		TM helix 1	118..144	CDD:320189	8/25 (32%)
		TM helix 2	151..177	CDD:320189	11/25 (44%)
		TM helix 3	189..219	CDD:320189	13/29 (45%)
		TM helix 4	232..255	CDD:320189	8/22 (36%)
		TM helix 5	272..297	CDD:320189	9/25 (36%)
		7tm_GPCRs	<533..605	CDD:475119	26/76 (34%)
		TM helix 6	539..561	CDD:320189	9/21 (43%)
		TM helix 7	573..598	CDD:320189	9/24 (38%)
CHRM5	NP_036257.1	7tmA_mAChR_M5	31..>225	CDD:320427	77/194 (40%)
		TM helix 1	32..58	CDD:320427	8/25 (32%)
		TM helix 2	65..91	CDD:320427	11/25 (44%)
		TM helix 3	103..133	CDD:320427	13/29 (45%)
		TM helix 4	145..168	CDD:320427	9/23 (39%)
		TM helix 5	190..219	CDD:320427	11/28 (39%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	262..294		12/71 (17%)
		7tm_GPCRs	<435..514	CDD:475119	28/79 (35%)
		TM helix 6	441..463	CDD:410628	9/21 (43%)
		TM helix 7	474..499	CDD:410628	9/24 (38%)