DRSC/TRiP Functional Genomics Resources

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Protein Alignment TyrR and CHRM1

DIOPT Version :10

Sequence 1:NP_650652.1 Gene:TyrR / 42136 FlyBaseID:FBgn0038542 Length:631 Species:Drosophila melanogaster
Sequence 2:NP_000729.2 Gene:CHRM1 / 1128 HGNCID:1950 Length:460 Species:Homo sapiens


Alignment Length:538 Identity:147/538 - (27%)
Similarity:215/538 - (39%) Gaps:135/538 - (25%)


- Green bases have known domain annotations that are detailed below.


  Fly   114 WQGIILIAVFATFIVVTVIGNTLVILAILTTRRLRTITNCFVMSLAVADLLVGIFVMPPAVAVHL 178
            ||...:........:.||.||.||:::......|:|:.|.|::|||.|||::|.|.|.......|
Human    23 WQVAFIGITTGLLSLATVTGNLLVLISFKVNTELKTVNNYFLLSLACADLIIGTFSMNLYTTYLL 87

  Fly   179 IGSWQLGWVLCDIWISLDVLLCTASILSLCAISVDRYLAVTRPLTYSRKRRSKRLALIMILIVWL 243
            :|.|.||.:.||:|::||.:...||:::|..||.|||.:|||||:|..||..:|.|| ||.:.||
Human    88 MGHWALGTLACDLWLALDYVASNASVMNLLLISFDRYFSVTRPLSYRAKRTPRRAAL-MIGLAWL 151

  Fly   244 LALAITCPPMLGW-YEPGRRDL--RECRYNQ--NEGYVIF-SAMGSFFIPMAVMIYVYARISCVI 302
            ::..:..|.:|.| |..|.|.:  .:| |.|  ::..:.| :||.:|::|:.||..:|.||    
Human   152 VSFVLWAPAILFWQYLVGERTVLAGQC-YIQFLSQPIITFGTAMAAFYLPVTVMCTLYWRI---- 211

  Fly   303 ASRHDNMTDISVHNKKFKRYTAADVENELSEQEQHSSVGQRQRQATSRTFSNQTIAKELQDMMLS 367
                                                     .|:..:|       |:||      
Human   212 -----------------------------------------YRETENR-------AREL------ 222

  Fly   368 DSDNCAAMGAGGAGGGGGGASSATGGTHCQSLLALPSGGVGGSMGCAKNGCYELTRPSSLKRA-- 430
                 ||:......|.|||:||::..:         ..|..||.......|....|...|.:|  
Human   223 -----AALQGSETPGKGGGSSSSSERS---------QPGAEGSPETPPGRCCRCCRAPRLLQAYS 273

  Fly   431 -------STASTTITTMTSGMGPGSSLLDAQWQSQPPGQTGQVQTHSLSQPPRTHS---FRHSHG 485
                   ...|....|.:.|..|||.::.......|..|.      ...||||:..   .|.:..
Human   274 WKEEEEEDEGSMESLTSSEGEEPGSEVVIKMPMVDPEAQA------PTKQPPRSSPNTVKRPTKK 332

  Fly   486 ERDRERLRSHHHHPHYHHQAGVTTTSTSGNTSANTNSKSLSNRIT-SLKKENKTTQTLSIVVGGF 549
            .|||                       :|........:.|:.|.| ||.||.|..:|||.::..|
Human   333 GRDR-----------------------AGKGQKPRGKEQLAKRKTFSLVKEKKAARTLSAILLAF 374

  Fly   550 IACWLPFFINYLITPFLAEHQASQMLAKALTWLGWFNSAINPFIYAFYSVDFRAAF--------- 605
            |..|.|:.|..|::.| .:....:.|.:...||.:.||.|||..||..:..||..|         
Human   375 ILTWTPYNIMVLVSTF-CKDCVPETLWELGYWLCYVNSTINPMCYALCNKAFRDTFRLLLLCRWD 438

  Fly   606 ---WRLTCKRFFSAGQKP 620
               ||...||..|..:.|
Human   439 KRRWRKIPKRPGSVHRTP 456

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
TyrRNP_650652.1 7tmA_tyramine_R-like 118..>304 CDD:320189 71/191 (37%)
TM helix 1 118..144 CDD:320189 6/25 (24%)
TM helix 2 151..177 CDD:320189 11/25 (44%)
TM helix 3 189..219 CDD:320189 13/29 (45%)
TM helix 4 232..255 CDD:320189 8/22 (36%)
TM helix 5 272..297 CDD:320189 8/25 (32%)
7tm_GPCRs <533..605 CDD:475119 25/71 (35%)
TM helix 6 539..561 CDD:320189 8/21 (38%)
TM helix 7 573..598 CDD:320189 10/24 (42%)
CHRM1NP_000729.2 7tmA_mAChR_M1 26..429 CDD:341356 138/506 (27%)
TM helix 1 27..53 CDD:341356 6/25 (24%)
TM helix 2 60..86 CDD:341356 11/25 (44%)
TM helix 3 98..128 CDD:341356 13/29 (45%)
TM helix 4 140..163 CDD:341356 8/23 (35%)
TM helix 5 185..214 CDD:341356 10/73 (14%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 225..256 9/39 (23%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 274..297 3/22 (14%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 310..351 11/69 (16%)
TM helix 6 358..388 CDD:341356 12/29 (41%)
TM helix 7 397..422 CDD:341356 10/24 (42%)

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