Protein Alignment TyrR and LOC11175717

DIOPT Version :10

• Sequence 1: NP_650652.1
• Gene: TyrR / 42136
• FlyBaseID: FBgn0038542
• Length: 631
• Species: Drosophila melanogaster
• Sequence 2: XP_061507703.1
• Gene: LOC11175717 / 11175717
• VectorBaseID: AGAMI1_012729
• Length: 809
• Species: Anopheles gambiae
• Alignment Length: 765
• Identity: 340/765 - (44%)
• Similarity: 427/765 - (55%)
• Gaps: 164/765 - (21%)

  Fly     4 NLQLNNLSAIYPSLMYVAASSSSLRGLGLGSGVGVGG-------LPENISIVYEDAGNG------ 55
            :|:|...|...|||   |||::|   :|..:...|||       |..|:|.:.| ||:|
Mosquito    69 SLELTTRSRSVPSL---AASAAS---IGSAASHVVGGRSRTLAALSANVSELVE-AGSGRAYDPA 126

  Fly    56 -----------TGGGGVGGVGGG---------YPSGPNGTDAVALTEPGPTAPVT---------- 90
                       .....:..|..|         :...|..||...|...|.:|..|
Mosquito   127 LYDDGRSLYDPLAAATITTVSIGNTTVQPATVFGPRPGVTDGSVLIGSGTSAATTLVVDLVGTVD 191

  Fly    91 -TFNYYNESAAAAEWAHFYDLVLSWQGIILIAVFATFIVVTVIGNTLVILAILTTRRLRTITNCF 154
             |.......:|..|  ||  |:.:||..:::.:|...|||||||||||||:::|||||||:||||
Mosquito   192 PTARQLELPSAMDE--HF--LIANWQDCVVVILFCLLIVVTVIGNTLVILSVITTRRLRTVTNCF 252

  Fly   155 VMSLAVADLLVGIFVMPPAVAVHLIGSWQLGWVLCDIWISLDVLLCTASILSLCAISVDRYLAVT 219
            ||||||||.|||||||||||||||:|||||||:||||||||||||||||||||||||:|||||||
Mosquito   253 VMSLAVADWLVGIFVMPPAVAVHLMGSWQLGWILCDIWISLDVLLCTASILSLCAISIDRYLAVT 317

  Fly   220 RPLTYSRKRRSKRLALIMILIVWLLALAITCPPMLGWYEPGRRDLRECRYNQNEGYVIFSAMGSF 284
            :||.|||:||||||||:|||:||:|||||||||:|||||||||:|.:||||||||||:|||||||
Mosquito   318 QPLNYSRRRRSKRLALLMILVVWVLALAITCPPILGWYEPGRRELDQCRYNQNEGYVVFSAMGSF 382

  Fly   285 FIPMAVMIYVYARISCVIASRHDNMTDISVHNKKFKRYTAADVENELSEQEQHSSVGQRQRQATS 349
            ||||.||:|||.|||||:|||||.||:|.|| ||..|....:.:...|||:......:|:|.::.
Mosquito   383 FIPMTVMVYVYVRISCVVASRHDKMTEIEVH-KKSHRVREPEEDGYQSEQDPIPLSPKRKRSSSQ 446

  Fly   350 RTFSNQTIAKELQDMMLSDSDNCAAMGAGGAGGGGGGAS------------SATGG-THCQ-SLL 400
            .:.:..|...:|..|:    |.  .:|||......|..:            :.||| |..| ::|
Mosquito   447 LSTATTTYVAQLGPML----DE--GVGAGQPPKPAGKRNNHKHGHYELMDLNTTGGSTQSQTTIL 505

  Fly   401 ALPSGGVGGSMG------CAKNGCYE--------------------------LTRP---SSLKRA 430
            |....|.||..|      .|..|.:.                          |..|   |:....
Mosquito   506 AAAGNGTGGPTGDTSTASAAAEGHHHHQEQLRQRTYDDGTSLDAIVDDPAVVLAGPGSGSTESNT 570

  Fly   431 STASTTITTMTSGMG----PGSSLLDAQWQSQPPGQTGQVQTHSL----------SQPPRTHSFR 481
            |||:||...:::.:.    |.::.|.:...|....|:.:.|:||:          |.|..:..|.
Mosquito   571 STAATTAAPVSASVNYNKLPSTAELWSSGNSVFNQQSHKPQSHSMASFAGAAGAGSPPNHSQHFH 635

  Fly   482 HSHGERDRERLRSHHHHPHYHHQAGVT--------------------TTST-------SGNTSAN 519
            |.|        ..||||.|:||:...|                    ||||       .|.|..|
Mosquito   636 HHH--------HHHHHHHHHHHEGRPTAALAAATGGLRRNNTVNTSITTSTCSSVQLVGGRTGGN 692

  Fly   520 T---NSKSLSNRITSLKKENKTTQTLSIVVGGFIACWLPFFINYLITPFLAEHQASQMLAKALTW 581
            .   :.||||:||:|:|:|||||:||||||||||||||||||:|:|||||.:......|::..||
Mosquito   693 NIRIHQKSLSSRISSMKRENKTTRTLSIVVGGFIACWLPFFIHYIITPFLPKDWTVPKLSEFFTW 757

  Fly   582 LGWFNSAINPFIYAFYSVDFRAAFWRLTCKRFFSAGQKPQFPT-NTMSIR 630
            |||.||||||||||||||||||||||||.:|||...:|..|.. :.:|:|
Mosquito   758 LGWINSAINPFIYAFYSVDFRAAFWRLTLRRFFRNSEKAPFANIHNLSMR 807

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TyrR	NP_650652.1	7tmA_tyramine_R-like	118..>304	CDD:320189	154/185 (83%)
		TM helix 1	118..144	CDD:320189	14/25 (56%)
		TM helix 2	151..177	CDD:320189	24/25 (96%)
		TM helix 3	189..219	CDD:320189	28/29 (97%)
		TM helix 4	232..255	CDD:320189	18/22 (82%)
		TM helix 5	272..297	CDD:320189	21/24 (88%)
		7tm_GPCRs	<533..605	CDD:475119	54/71 (76%)
		TM helix 6	539..561	CDD:320189	19/21 (90%)
		TM helix 7	573..598	CDD:320189	17/24 (71%)
LOC11175717	XP_061507703.1	None