Protein Alignment TyrR and htr4

DIOPT Version :10

• Sequence 1: NP_650652.1
• Gene: TyrR / 42136
• FlyBaseID: FBgn0038542
• Length: 631
• Species: Drosophila melanogaster
• Sequence 2: XP_009289337.1
• Gene: htr4 / 101882850
• ZFINID: ZDB-GENE-160114-31
• Length: 423
• Species: Danio rerio
• Alignment Length: 514
• Identity: 124/514 - (24%)
• Similarity: 183/514 - (35%)
• Gaps: 220/514 - (42%)

  Fly   117 IILIAVFATFIVVTVIGNTLVILAILTTRRLRTI-TNCFVMSLAVADLLVGIFVMPPAVAVHLI- 179
            :.||:..:..::::|:||.||::|:...|:||.| ||.|::|||.|||||.:.|||.. |:.||
Zfish    60 VALISFLSLVMLMSVLGNLLVMVAVCKDRQLRKIKTNYFIVSLAFADLLVSVLVMPFG-AIELIH 123

  Fly   180 GSWQLGWVLCDIWISLDVLLCTASILSLCAISVDRYLAV-TRPLTYSRKRRSKRLALIMILIVWL 243
            .:|..|...|.:..||||||.|||||.||.||:|||.|: .:||.|..|....|:.| ||...|:
Zfish   124 QNWIYGETFCLVRTSLDVLLTTASILHLCCISLDRYYAICCQPLVYRNKMTPLRVTL-MIGGCWI 187

  Fly   244 LALAIT-CPPMLGWYEPGRRDLRE----------CRYNQNEGYVIFSAMGSFFIPMAVMIYVYAR 297
            :...|: .|.|.||...|.:||.:          |.:..|:.|.:..::.:|::|:.:|:..|.|
Zfish   188 IPTVISFLPIMQGWNSIGIKDLIDKRKISGNSTVCVFMVNKPYALTCSVVAFYLPLVLMVLAYQR 252

  Fly   298 ISCVIASRHDNMTDISVHNKKFKRYTAADVENELSEQEQHSSVGQRQRQATSRTFSNQTIAKELQ 362
            |                       |..|        :|....:...||
Zfish   253 I-----------------------YVTA--------REHARQISMLQR----------------- 269

  Fly   363 DMMLSDSDNCAAMGAGGAGGGGGGASSATGGTHCQSLLALPSGGVGGSMGCAKNGCYELTRPSSL 427
                              .||.|.|.||
Zfish   270 ------------------AGGAGNADSA------------------------------------- 279

  Fly   428 KRASTASTTITTMTSGMGPGSSLLDAQWQSQPPGQTGQVQTHSLSQPPRTHSFRHSHGERDRERL 492
                                                                          :..
Zfish   280 --------------------------------------------------------------DHQ 282

  Fly   493 RSHHHHPHYHHQAGVTTTSTSGNTSANTNSKSLSNRITSLKKENKTTQTLSIVVGGFIACWLPFF 557
            |:|.                                   ::.|.|..:||.|::|.|..||.|||
Zfish   283 RNHR-----------------------------------MRTETKAAKTLCIIMGCFCLCWAPFF 312

  Fly   558 INYLITPFLAEHQASQMLAKALTWLGWFNSAINPFIYAFYSVDFRAAFWRLTC---KRF 613
            |..::.||: ::...:.|..|..|||:.||.:||.:|||.:..||.||..:.|   ||:
Zfish   313 ITNVVDPFI-DYSVPEQLWAACLWLGYINSMLNPILYAFLNKSFRRAFLIILCCGHKRY 370

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TyrR	NP_650652.1	7tmA_tyramine_R-like	118..>304	CDD:320189	77/199 (39%)
		TM helix 1	118..144	CDD:320189	8/25 (32%)
		TM helix 2	151..177	CDD:320189	15/25 (60%)
		TM helix 3	189..219	CDD:320189	20/30 (67%)
		TM helix 4	232..255	CDD:320189	8/23 (35%)
		TM helix 5	272..297	CDD:320189	6/24 (25%)
		7tm_GPCRs	<533..605	CDD:475119	29/71 (41%)
		TM helix 6	539..561	CDD:320189	11/21 (52%)
		TM helix 7	573..598	CDD:320189	12/24 (50%)
htr4	XP_009289337.1	7tmA_5-HT4	60..359	CDD:320184	119/501 (24%)
		TM helix 1	61..87	CDD:320184	8/25 (32%)
		TM helix 2	95..121	CDD:320184	15/26 (58%)
		TM helix 3	133..163	CDD:320184	20/29 (69%)
		TM helix 4	176..199	CDD:320184	7/23 (30%)
		TM helix 5	227..256	CDD:320184	9/51 (18%)
		TM helix 6	288..318	CDD:320184	13/29 (45%)
		TM helix 7	327..352	CDD:320184	12/24 (50%)