Protein Alignment TyrR and hrh4.d1

DIOPT Version :10

• Sequence 1: NP_650652.1
• Gene: TyrR / 42136
• FlyBaseID: FBgn0038542
• Length: 631
• Species: Drosophila melanogaster
• Sequence 2: XP_004915714.2
• Gene: hrh4.d1 / 101734803
• XenbaseID: XB-GENE-22168426
• Length: 382
• Species: Xenopus tropicalis
• Alignment Length: 495
• Identity: 114/495 - (23%)
• Similarity: 182/495 - (36%)
• Gaps: 161/495 - (32%)

  Fly   117 IILIAVFATFIVVTVIGNTLVILAILTTRRLRTITNCFVMSLAVADLLVGIFVMPPAVAVHLIGS 181
            ::||.:.|..|::.|:||::||||.:..:|||:.:|.|:::||:.|.|||.|.:|..:.....|.
 Frog    33 VLLIILIALLIILIVLGNSIVILAFIVDKRLRSQSNFFLLNLAICDFLVGAFSIPLYIPFLFSGK 97

  Fly   182 WQLGWVLCDIWISLDVLLCTASILSLCAISVDRYLAVTRPLTY-SRKRRSKRLALIMILIVWLLA 245
            |.||..||.:|:.||.....||...:..||.||:|:||:.:.| :::||..:.||.|: :.|:.:
 Frog    98 WMLGRFLCKLWLILDFTTSAASAFGVVLISYDRFLSVTKAVLYRTQQRRHSQTALKMV-VAWIFS 161

  Fly   246 LAITCPPMLGWYEPGRRDLRECRYNQNEGYVIFSAMGSFFIPMAVMIYVYARISCVIASRHD--- 307
            ..|..|.::.|      ::....|..||    :|....||.....::       |  ||..|
 Frog   162 FLIYGPAIIFW------EILTGTYETNE----YSCRAGFFDAWYFLL-------C--ASSLDFAF 207

  Fly   308 NMTDISVHNKKFKRYTAADVENELSEQEQHSSVGQRQRQATSRTFSNQTIAKELQDMMLSDSDNC 372
            .|..||..|.:.                 :.::.:|.|             |:.....:|:....
 Frog   208 PMISISFFNMRI-----------------YWNIKKRSR-------------KKRNSCQMSEEQKT 242

  Fly   373 AAMGAGGAGGGGGGASSATGGTHCQSLLALPSGGVGGSMGCAKNGCYELTRPSSLKRASTASTTI 437
            .             ||.....||.  :|:.|.|                    ..|..|:.:.|:
 Frog   243 E-------------ASPYIIATHI--VLSCPKG--------------------KEKVDSSLNKTV 272

  Fly   438 TTMTSGMGPGSSLLDAQWQSQPPGQTGQVQTHSLSQPPRTHSFRHSHGERDRERLRSHHHHPHYH 502
            ...            |:...:|..||       :|.||
 Frog   273 NDF------------AKQSFEPSSQT-------MSGPP--------------------------- 291

  Fly   503 HQAGVTTTSTSGNTSANTNSKSLSNRITSLK--KENKTTQTLSIVVGGFIACWLPFFINYLITPF 565
                                    ||::.:|  ::.|..::|:|:|..|..||.|:.....|...
 Frog   292 ------------------------NRVSVIKLSRDKKVARSLTILVSVFALCWAPYSFLVSIRAA 332

  Fly   566 LAEHQASQMLAKALTWLGWFNSAINPFIYAFYSVDFRAAF 605
            ...:.......|...||.|.||||||.:|......||.||
 Frog   333 CQGYCIDFFWYKVTAWLLWTNSAINPVLYPMCHKSFRKAF 372

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TyrR	NP_650652.1	7tmA_tyramine_R-like	118..>304	CDD:320189	59/186 (32%)
		TM helix 1	118..144	CDD:320189	11/25 (44%)
		TM helix 2	151..177	CDD:320189	10/25 (40%)
		TM helix 3	189..219	CDD:320189	11/29 (38%)
		TM helix 4	232..255	CDD:320189	6/22 (27%)
		TM helix 5	272..297	CDD:320189	5/24 (21%)
		7tm_GPCRs	<533..605	CDD:475119	23/73 (32%)
		TM helix 6	539..561	CDD:320189	7/21 (33%)
		TM helix 7	573..598	CDD:320189	11/24 (46%)
hrh4.d1	XP_004915714.2	7tmA_Histamine_H3R_H4R	47..372	CDD:320176	108/479 (23%)
		TM helix 2	67..94	CDD:320176	10/26 (38%)
		TM helix 3	105..135	CDD:320176	11/29 (38%)
		TM helix 4	150..168	CDD:320176	5/18 (28%)
		TM helix 5	193..223	CDD:320176	8/55 (15%)
		TM helix 6	300..330	CDD:320176	8/29 (28%)
		TM helix 7	340..365	CDD:320176	11/24 (46%)