Protein Alignment TyrR and chrm3

DIOPT Version :10

• Sequence 1: NP_650652.1
• Gene: TyrR / 42136
• FlyBaseID: FBgn0038542
• Length: 631
• Species: Drosophila melanogaster
• Sequence 2: XP_002935876.2
• Gene: chrm3 / 100493547
• XenbaseID: XB-GENE-940647
• Length: 588
• Species: Xenopus tropicalis
• Alignment Length: 517
• Identity: 144/517 - (27%)
• Similarity: 232/517 - (44%)
• Gaps: 62/517 - (11%)

  Fly   114 WQGIILIAVFATFI-VVTVIGNTLVILAILTTRRLRTITNCFVMSLAVADLLVGIFVMPPAVAVH 177
            || :.|||.|:..| :||||||.|||||....::|:|:.|.|::|||.|||::|:..|.......
 Frog    75 WQ-VFLIASFSGIIALVTVIGNILVILAFKVNKQLKTVNNYFLLSLACADLIIGVISMNLFTTYI 138

  Fly   178 LIGSWQLGWVLCDIWISLDVLLCTASILSLCAISVDRYLAVTRPLTYSRKRRSKRLALIMILIVW 242
            ::..|.:|.:.||:|:.:|.:...||:::|..||.|||.::||||||..||.:|| |.|||.:.|
 Frog   139 IMDHWIMGSLACDLWLMIDYVASNASVMNLLVISFDRYFSITRPLTYRTKRTTKR-AGIMIGLAW 202

  Fly   243 LLALAITCPPMLGW-YEPGRRDL--RECRYNQ--NEGYVIF-SAMGSFFIPMAVMIYVYARISCV 301
            :::..:..|.:|.| |..|:|.:  .|| :.|  .|..:.| :|:.:|::|:::|..:|.||...
 Frog   203 IISFILWAPAILFWQYFVGKRTVPSDEC-FIQFFTEPIITFGTAIAAFYLPVSIMTILYWRIYKE 266

  Fly   302 IASRHDNMTDISVHNKKFKRYTAADVENELSEQEQHSSVG-QRQRQATSRTFSNQTIAKELQDMM 365
            ...|...:..:.....|.:   ...:.:.....:.:|:.. ||..:.:|||..:....:....|.
 Frog   267 TEKRTKELAGLQASGGKLE---VPGLSHRTGNAKGNSNYKIQRNIKFSSRTRYSWCTFRFKPKMC 328

  Fly   366 LSDSDNCAAMGAGGAGGGGGGASSATGGTHCQSLLALPSGGVGGSMGCAKN--GCYELTRPSSLK 428
            .||......           ..||:....|..:..:|.:.|........:|  ..|.:.    ||
 Frog   329 KSDKKQIEQ-----------DQSSSESWNHNDANASLDNSGTSDEEDAPENPRAIYSIV----LK 378

  Fly   429 RASTASTTITTMTSGMGPGSSLLDAQWQSQPPGQTGQVQTHSLSQPPRTHSFRHSHGER---DRE 490
            ..              |..|.|...:.||...|.|.:....|..||.... |::.:.:|   :::
 Frog   379 LP--------------GHNSVLSKTKSQSSNQGNTSKGMQKSGPQPKELR-FKNLNSQRNLQNKD 428

  Fly   491 RLRSHHHHPHYHHQAGVTTTST------------SGNTSANTNSKSLSNRITSLKKENKTTQTLS 543
            ...|....|...|....::.:|            :...:|.|.::....:..||.||.|..||||
 Frog   429 ESISVSLSPQTDHSMNTSSKTTAPLPISFKEIALAKRFAAKTRNQITKRKRMSLIKEKKAAQTLS 493

  Fly   544 IVVGGFIACWLPFFINYLITPFLAEHQASQMLAKALTWLGWFNSAINPFIYAFYSVDFRAAF 605
            .::..||..|.|:.|..|:..| .|....::......||.:.||.|||..||..:..||..|
 Frog   494 AILLAFIITWAPYNIMVLVNTF-CESCIPRIYWNLGYWLCYINSTINPICYALCNKTFRTTF 554

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TyrR	NP_650652.1	7tmA_tyramine_R-like	118..>304	CDD:320189	75/192 (39%)
		TM helix 1	118..144	CDD:320189	16/26 (62%)
		TM helix 2	151..177	CDD:320189	10/25 (40%)
		TM helix 3	189..219	CDD:320189	12/29 (41%)
		TM helix 4	232..255	CDD:320189	7/22 (32%)
		TM helix 5	272..297	CDD:320189	7/25 (28%)
		7tm_GPCRs	<533..605	CDD:475119	26/71 (37%)
		TM helix 6	539..561	CDD:320189	9/21 (43%)
		TM helix 7	573..598	CDD:320189	9/24 (38%)
chrm3	XP_002935876.2	7tmA_mAChR_M3	75..>279	CDD:320426	78/206 (38%)
		TM helix 1	79..105	CDD:320426	16/25 (64%)
		TM helix 2	112..139	CDD:320426	10/26 (38%)
		TM helix 3	150..180	CDD:320426	12/29 (41%)
		TM helix 4	192..215	CDD:320426	8/23 (35%)
		TM helix 5	237..266	CDD:320426	9/28 (32%)
		7tm_GPCRs	<483..563	CDD:475119	27/73 (37%)
		TM helix 6	489..511	CDD:320426	9/21 (43%)
		TM helix 7	522..547	CDD:320426	9/24 (38%)