Protein Alignment TyrR and drd2

DIOPT Version :9

• Sequence 1: NP_001287381.1
• Gene: TyrR / 42136
• FlyBaseID: FBgn0038542
• Length: 631
• Species: Drosophila melanogaster
• Sequence 2: XP_031762362.1
• Gene: drd2 / 100493063
• XenbaseID: XB-GENE-1005779
• Length: 438
• Species: Xenopus tropicalis
• Alignment Length: 577
• Identity: 162/577 - (28%)
• Similarity: 245/577 - (42%)
• Gaps: 158/577 - (27%)

  Fly    44 NISIVYEDAGNGTGGGGVGGVGGGYPSGPNGTDAVALTEPGPTAPVTTFNYYNESAAAAEWAHFY 108
            |:|:..:|..|||.|..|       ...|:                  :|||
 Frog     5 NLSMYNDDINNGTNGTAV-------DQKPH------------------YNYY------------- 31

  Fly   109 DLVLSWQGIILIAVFATFIV-VTVIGNTLVILAILTTRRLRTITNCFVMSLAVADLLVGIFVMPP 172
                        |:..|.:: |.|.||.||.:|:...:.|:|.||..::|||||||||...|||.
 Frog    32 ------------AMLLTLLIFVIVFGNVLVCIAVSREKALQTTTNYLIVSLAVADLLVATLVMPW 84

  Fly   173 AVAVHLIGSWQLGWVLCDIWISLDVLLCTASILSLCAISVDRYLAVTRPLTYSRKRRSKRLALIM 237
            .|.:.::|.|:...:.|||:::|||::||||||:|||||:|||.||..|:.|:.:..|||...:|
 Frog    85 VVYMEVVGEWRFSRIHCDIFVTLDVMMCTASILNLCAISIDRYTAVAMPMLYNTRYSSKRRVTVM 149

  Fly   238 ILIVWLLALAITCPPMLGWYEPGRRDLRECRYNQNEGYVIFSAMGSFFIPMAVMIYVYARISCVI 302
            |.:||:|:.||:||.:.|......   :.|..: |..:||:|::.||::|..|.:.||.:|..|:
 Frog   150 ISVVWVLSFAISCPLLFGLNNTAS---KVCIID-NPAFVIYSSIVSFYVPFIVTLLVYVQIYIVL 210

  Fly   303 ASRHDNMTDISVHNKKFKRYTAADVENELSEQEQHSSVGQRQRQATSRTFSNQTIAKELQDMMLS 367
            ..|                                     |:|..|.|......:.        :
 Frog   211 RKR-------------------------------------RKRVNTKRNSHGVEVN--------A 230

  Fly   368 DSDNCAAMGAGGAGGGGGGASSATGGTHCQSLLALPSGGVGGSMGCA----KNGCYELTRPSSLK 428
            ..|.|                     ||.:.:..           ||    .||.:    |:..|
 Frog   231 HKDKC---------------------THPEDVKL-----------CAVFVKSNGSF----PTDKK 259

  Fly   429 RASTASTTITTMTSGMGPGSSLLDAQWQSQPPGQT----GQVQTHSLSQPPRTHSFRHSH--GER 487
            :          :.:|..|....::....:.||.:|    .....|.|:.|..::...:::  ...
 Frog   260 K----------VEAGNHPEDMDVEMMSSTSPPEKTKHKSASPNHHQLAVPATSNQCNNANLPSPV 314

  Fly   488 DRERLRSHHHHPHYHHQ-AGVTTTSTSGNTSANTNSKSLSNRITSLKKENKTTQTLSIVVGGFIA 551
            |.......:.||....: |.|....|..|....|:.|::|.|..|..||.|.||.|:||:|.||.
 Frog   315 DSPYKAEKNGHPKDSTKPAKVFEIQTMPNGKTRTSIKTMSKRKLSQHKEKKATQMLAIVLGVFII 379

  Fly   552 CWLPFFINYLITPFLAEHQASQMLAKALTWLGWFNSAINPFIYAFYSVDFRAAFWRL 608
            |||||||.:::. ........|.|..|.||||:.|||:||.||..::|:||.||.::
 Frog   380 CWLPFFIIHILN-MHCNCNIPQALYSAFTWLGYVNSAVNPIIYTTFNVEFRKAFIKI 435

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TyrR	NP_001287381.1	7tm_4	127..>249	CDD:304433	59/122 (48%)
		7tm_1	133..>298	CDD:278431	72/164 (44%)
drd2	XP_031762362.1	7tmA_D2_dopamine_R	29..432	CDD:320435	151/523 (29%)
		TM helix 1	31..55	CDD:320435	10/48 (21%)
		TM helix 2	64..86	CDD:320435	13/21 (62%)
		TM helix 3	102..124	CDD:320435	15/21 (71%)
		TM helix 4	148..164	CDD:320435	8/15 (53%)
		TM helix 5	181..204	CDD:320435	8/22 (36%)
		TM helix 6	367..389	CDD:320435	15/21 (71%)
		TM helix 7	400..425	CDD:320435	14/24 (58%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D189663at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.010